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NANOGENESEQ CHIP

Ajith Kumar and Arun Kumar*

srkac hosital
trivandrum 695003 India

This is an abstract for a presentation given at the
1st Conference on Advanced Nanotechnology:
Research, Applications, and Policy

 

NANOGENESEQ Inc. has developed a highly innovative and efficient system, the NANOGENESEQ SYSTEM, which optimize DNA and protein sequencing at both the efficiency and cost level. NANOGENESEQas a system comprises both hardware and software elements. The NANOGENESEQsystem consists of two components: the NANOCHIP (NC) and the SPIRAL LASER SCANNER (SLS). NC is a cube like structure composed of juxtaposed silicon plates (wafers). It has a multiple sieve architecture made possible by nanoscale channels etched in the wafers. The nanochannels of each wafer are connected to the channels of the wafer lying immediately below , thus forming a sponge-like device. It is this multiple sieve sponge-like architecture that allows NC to separate large molecules according to mass and shape.

SLS is a moving semiconductor laser incorporated within the NC, which is capable of detecting the movement of the molecules and DNA segments flowing through the NC. Its capability to move in a spiral fashion allows it to measure the size and shape of molecules as they arrive at the end of each of the nanochannels and empty into the detection chamber. NC and SLS, being made of semiconductor materials that can be wired to microprocessors down to the nanoscale level, can be remotely controlled as to modify key parameters, such as flow rate of molecules within the NC and the temperature in discrete portions of the device. This in turn allows to remotely control, through the use of advanced self-learning algorithms, the order in which molecules are separated and detected.

The key advantages of NC are:

NANOGENESEQ(NC and SLS) allows to selectively separate and detect individual molecules within an heterogeneous mixture

NANOGENESEQincrease the data readout on single molecules allowing to take 3D measurements, the changes in shape, the speed of changes in shape the entropy of molecule flow through the device and the flexibility of the device itself; all these measurements allow to predict the molecule type and are the data feed for the self-learning algorithms , thus improving their predictive capacity over time. This is especially useful for proteomics studies and for molecular self-assembly applications.

NANOGENESEQ allows to measure the entropy of flow and device flexibility, thus allowing to control the separation and detection process. The entropy of flow be modified via software so that the chip can be commanded to perform different tasks, according to the detection target.

NANOGENESEQ is modular, thus allowing to build arrays of NCs & SLS to perform multiple functions and tasks.

NANOGENESEQ has longer chip life cycle and reduces energy costs during operations . The flexibility of the chip reduces the frictional and heating effects, so the chip doesnít need any cooling devices, like cooling fans. This drastically reduces the cost during operations and results in longer chip life.

Sequencing advantages:

In the case of DNA, NANOGENESEQtriples the amount of base pairs that can be sequenced on a given segment to 2100 from the current 700;

NANOGENESEQ widens the choice of fluorescent dyes that can be used , thus making multicolor detection a reality; multicolor detection , i.e. the use of multiple sets of 4 dyes each, will allow multiple simoultaneous sequencing of more than one fragment within the same sequencing step.

Proteomics advantages

NANOGENESEQ allows 3D scanning of molecules as they flow within the device, thus allowing to selectively detect individual protein forms as they move through the device. This translates into a much improved efficiency in screening studies

Integrating several NCs into a larger composite NANOGENESEQ (as in a chessboard arrangement) provides an extraordinary platform to do more integrative protein detection tasks with respect to current methods and this a key advantage for proteomics applications.

Molecular self-assembly

SLS provides the 3D measurements needed to identify and select possible self-assembly candidates within a mixture and NC can selectively separate them as to bring them within the same environment where they can explore self-assembly arrangements. This can be exploited to develop novel chemistries for use in nearly all fields, from advanced materials to pharmaceuticals.


*Corresponding Address:
Arun Kumar
medicine, srkac hosital
kunnil house, trivandrum 695003 India
Phone: ++91-471-2310179 Fax: ++91-471-2333614
Email: ajitharun@yahoo.com



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