The screening for specific biomolecular binding utilizing biochips bases usually on a fluorescence signal. Fluorescence detection is limited regarding the sensitivity, due to bleaching and quenching effects, and there is also a need for a sophisticated detection equipment for sensing and processing the signals. Nanobead labeling could overcome some of these obstacles, which is our motivation to explore the potential of this method. The techniques for attaching nanobeads to biomolecules are established, so that we focus our investigations on novel detection schemes. We developed a method based on the electrical detection of molecular binding events. This method could be highly parallelized as well as minimized, having the potential of fast read-out of large numbers of signals from a biochip.