In this paper, we report multidisciplinary research in design, analysis, control, modeling, and simulation of nanoscale machines (molecular nanomotors and nanogenerators with moving components). A wide class of innovative nanoscale machines is studied. In particular, novel rotational and translational nanomotors and nanogenerators with controlling nanocircuitry are examined. The nanomotors can be used as nanoswitches, nanologics, and nanomemories which are the basic components of nanocomputers. The nanogenerators can be used as nanoaccelerometers and nanogyroscopes (to measure linear and angular accelerations), nano shear stress sensors, nano flow sensors, etc. The rotational nanomachines have stator (stationary member) and rotor (movable member). Two rotating molecules (positive and negative doped molecules with +eq and -eq) and nanocylinder form the rotor (motion nanostructure), and the electromagnetic field is developed by the nanoantenna or nanowinding. The electromagnetic torque is produced, and motor rotates. A novel molecular bearing solution is proposed and examined. In addition to quantum phenomena, time-varying electromagnetic fields and feedback mechanism are thoroughly examined addressing operating and controlling principles of nanomachinery. The major emphasis is given to design nanomachines which are robust, reliable, and compliant to the desired specifications (temperature, pressure, vibration, et cetera). The proposed nanomachines allow us to overcome the well-known difficulties, and the researched solution provides a unified benchmarking avenue to analyze actuation/sensing - energy transfer - controlling - feedback mechanism - design at the nanoscale level.