Computational design of proteins satisfying predetermined geometric constraints produced stable proteins with the designed structure that are not found in nature.
Archive for the 'Molecular Nanotechnology' Category
A fully automated design protocol generates dozens of designs for proteins based on helix-loop-helix-loop repeat units that are very stable, have crystal structures that match the design, have very different overall shapes, and are unrelated to any natural protein.
Prof. William Goddard presented four advances from his research group that enable going from first principles quantum mechanics calculations to realistic nanosystems of interest with millions or billions of atoms.
DNA building blocks mimic biological ion channels to more precisely control which molecules can cross a biological membrane.
A molecular robotic arm synthesized from small synthetic organic molecules uses cyclic changes in pH and other reaction conditions to grab and release a cargo molecule, and swing the cargo back and forth between the two ends of the molecular platform.
Highly correlated electron motions resembling electron liquids rather than electron gases, and found in some transition metal oxides, may enable inexpensive substitution for expensive displays.
German researchers have used scaffolded DNA origami to adjust the angle of a DNA hinge joint by altering the length of special “adjuster helices”, causing molecules attached to the sides of the hinge to be displaced by as little as 0.04 nm.
Each time a laser pulse actuates the cis-trans isomerization of a single carbon-carbon double bond, a single-molecule nanosubmarine made of 244 atoms is driven forward 9 nm against Brownian diffusion.
Building on previous work on single atom transistors and single atom qubits, Australian researchers have incorporated a quantum error correction code to make possible a scalable 3D silicon chip architecture that could lead to operational quantum computers.
Independent rotation of two wheels attached to either end of an axle has been achieved in a light-driven artificial molecular motor, suggesting a basis for a nanometer-scale transport system.
DNA nanotechnology produces an artificial molecular machine that changes shape when it encounters a specific antibody or other protein molecule, and emits light to signal the target’s presence.
A novel application of supramolecular chemistry allows molecules to join in only one direction, providing a new way to control the shape of large molecules.
A lipid bilayer supported by a mica surface assisted the mobile self-assembly of DNA nanostructures of various shapes into micrometer-scale 2D lattices.
A free to read online edition of the classic 3-volume physics text developed from Richard Feynman’s legendary Cal Tech physics lectures, specially designed for online reading, has been made available by the California Institute of Technology and the Feynman Lectures Website.
Prof. Art Olson discussed how we understand what we cannot see directly, how we integrate data from different sources, and how to develop software tools to move forward.
Optimized Geek podcast featured Christine Peterson on the future of nanotechnology, human lifespan, artificial intelligence, finding love, and other topics.
DNA strands decorating cell membranes like ‘Velcro’ program the adhesion of cells to other cells or to extracellular matrices to build tiny tissue models.
The ability to dope graphene nanoribbons with boron atoms to atomic precision opens a range of possible new applications, from chemical sensing to nanoelectronics to photocatalysis to battery electrodes.
Designing a small DNA origami that can fold in several almost equivalent ways demonstrates how understanding and guiding the folding pathway can improve the efficiency of the folding process, potentially leading in more complex situations to higher yields of the desired nanostructure and fewer misfolded structures.
An extensive review of artificial molecular machines, their large-amplitude motions, and the changes these motions produce, emphasizes small molecules and the central role of chemistry in their design and operation.