Modeling DNA strand displacement cascades according to three simple rules can in principle mimic the temporal dynamics of any other chemical system, presenting a method to model regulatory networks even more complicated than those of biology.
Archive for the 'Molecular Nanotechnology' Category
Functional ribosomes with subunits engineered to not separate at the completion of each protein translation cycle make possible engineering systems to make a variety of novel polymers with novel properties.
An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.
Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.
Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.
At the 2013 Conference Joseph Puglisi described how single molecule fluorescence techniques were used to study changes in the conformation and composition of the ribosome, a large biomolecular nanomachine, during the process of translation of genetic information.
Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.
A molecular ring shuttles back and forth between two positions on a molecular axle held rigidly inside a solid state molecular lattice made from a metal organic framework.
By precise control of several factors, uniform high-performance monolayers of the semiconductor MoS2 have been obtained and used to fabricate field-effect transistors.
Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.
Recently highlighted in a C&EN article titled Simple Process Creates Near-Perfect Mirrors Out of a Metamaterial, researchers out of Vanderbilt University developed a method to self-assemble silicon nanostructures to achieve highly (Bragg-like) reflective mirrors which capitalize on nanoscale properties not present in bulk structures. The self-assembly method is far simpler than previous, conventional electron beam [...]
Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.
A US government Request for Information (RFI) is seeking suggestions for Nanotechnology-Inspired Grand Challenges for the Next Decade. The manufacture of atomically-precise materials is offered as #4 of 6 examples.
At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.
A combination of techniques has made possible the expansion of problems that can be handled by first-principles molecular dynamics from a few hundred atoms to a very large system containing 32,768 atoms.
Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.
Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.
A rotaxane-based single molecule pump combines cycling oxidation-reduction potential of the solution with kinetic barriers to moving backward to concentrate small ring molecules against an energy gradient.
A European Science and Technology Roadmap for Graphene, Related Two-Dimensional Crystals, and Hybrid Systems hints at the opportunities to be harvested from, and the need for, the development of atomically precise manufacturing (APM).
The Theory Prize was given for research into diamond nanoparticles; the Experimental Prize was given for development of scanning tunneling microscope (STM) technology.