Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.
Archive for the 'Molecular Nanotechnology' Category
Design and computational simulation of amyloid proteins of diverse functions from diverse sources enable the self-assembly of proteins that could provide scaffolds for diverse applications.
RNA origami brings new dimensions to nucleic acid nanotechnology by exploiting the much greater variety of RNA structural motifs (compared to DNA) to do what cannot easily be done with DNA origami, like fold into predetermined nanostructures rapidly while being transcribed.
Iterative coupling, purification, and cyclization of a large collection of organic building blocks promises a vast array of complex small and medium sized molecules as candidates for drug discovery, catalysis, and nanotechnology.
A commentary over at Gizmodo argues that ideas about molecular manufacturing that sounded like science fiction in 1986 now sound more like science fact.
The idea that nanorobots fabricated by atomically precise manufacturing processes are a likely part of our future, and that this is a good thing, is appearing more frequently, largely as a result of Drexler’s recent book Radical Abundance.
An overview of three decades of progress in DNA nanotechnology emphasizes bringing programmed motion to DNA nanostructures, including efforts to incorporate design principles from macroscopic mechanical engineering.
Variable length single-stranded DNA springs determine how far a hinge of double-stranded DNA joining two stiff sections of DNA origami can bend.
Scaffolded DNA origami is combined with hinges of single- or double-stranded DNA to built simple machines parts that have been combined to program simple to complex motions.
One example is presented of how well the meme is spreading that nanotechnology will evolve toward atomically precise manufacturing that will in turn bring forth a world of abundance.
Combinations of different types of DNA nanorobots, implementing different logic gates, work together to tag a specific type of cell in a living cockroach depending on the presence or absence of two protein signals.
Among the smallest molecular robots reported so far, a walker based on phenylarsonous acid with two organic thiol ligands as feet walks through a one-nanometer-diameter protein nanopore channel by taking 0.6 nanometer steps, by thiol exchange, from one cysteine residue to the next.
A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?
A new strategy to form bonds between carbon atoms opens the way to a wide variety of molecular architectures that had been difficult or impossible to access using previous methods.
Artificial enzymes have been created from nucleic acids that use synthetic molecules instead of ribose or deoxyribose sugars.
Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.
Advances in the de novo design of coiled-coil proteins made by two different research groups proceeding by two different routes demonstrate that the range of protein nanostructures potentially available for various molecular machine systems is significantly larger than the range of such structures already exploited by natural selection.
A general framework is presented for using 32-nucleotide DNA bricks to build large two-dimensional crystals up to 80 nm thick and incorporating sophisticated three-dimensional features.
Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.
The US National Science Foundation announced a new grant program to develop and apply next-generation networking to advance nanotechnology and other emerging technologies to meet important national needs.