Iterative coupling, purification, and cyclization of a large collection of organic building blocks promises a vast array of complex small and medium sized molecules as candidates for drug discovery, catalysis, and nanotechnology.
Archive for the 'Research' Category
In tests in a mouse model of advanced atherosclerosis, core-shell nanoparticles, composed of block copolymers and targeted to sites of inflammation and vascular injury, delivered a bioactive peptide that improved key properties of advanced plaques.
A commentary over at Gizmodo argues that ideas about molecular manufacturing that sounded like science fiction in 1986 now sound more like science fact.
Bulk nanoscale technologies were used to create three-segment nanowires of gold and nickel, and magnetic bearings of gold, nickel, and chromium. Combinations of DC and AC electric fields were used to assemble nanomotors that can spin at speeds up to 18,000r.p.m., and for up to 15 hours.
An overview of three decades of progress in DNA nanotechnology emphasizes bringing programmed motion to DNA nanostructures, including efforts to incorporate design principles from macroscopic mechanical engineering.
Mixing two different types of cylindrical nanoparticles causes them to reorganize into smaller spherical nanoparticles. A mechanism to release drugs only inside cells that internalize both types?
Computational simulations demonstrate that pentagonal tiling to give a variant of graphene based on pentagons rather than on hexagons is dynamically, thermally, and mechanically stable.
Applications of nanotechnology to wearable electronics and other portable devices will benefit from the discovery that adding an insulating layer to a piezoelectric nanostructure increases the output voltage by up to 200 times.
A simple method of producing nanoporous alumina surface discourages bacteria from attaching and forming biofilms, with potential applications in medicine, dentistry, and food processing.
Variable length single-stranded DNA springs determine how far a hinge of double-stranded DNA joining two stiff sections of DNA origami can bend.
Scaffolded DNA origami is combined with hinges of single- or double-stranded DNA to built simple machines parts that have been combined to program simple to complex motions.
To measure in-plane piezoelectric stress, an MoS2 film was suspended on HSQ posts and clamped by two Au electrodes. When the film was indented with a scanning AFM probe, the induced stress changed the load on the cantilever, which was observed by the deflection of a laser beam. Credit: Berkeley Lab
Combinations of different types of DNA nanorobots, implementing different logic gates, work together to tag a specific type of cell in a living cockroach depending on the presence or absence of two protein signals.
New software makes it possible to generate 3D structures of proteins without artificially incorporating metal atoms in the proteins, making it possible to study many molecular machines using data that could not previously be analyzed.
Among the smallest molecular robots reported so far, a walker based on phenylarsonous acid with two organic thiol ligands as feet walks through a one-nanometer-diameter protein nanopore channel by taking 0.6 nanometer steps, by thiol exchange, from one cysteine residue to the next.
A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?
A new strategy to form bonds between carbon atoms opens the way to a wide variety of molecular architectures that had been difficult or impossible to access using previous methods.
Artificial enzymes have been created from nucleic acids that use synthetic molecules instead of ribose or deoxyribose sugars.
Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.
Advances in the de novo design of coiled-coil proteins made by two different research groups proceeding by two different routes demonstrate that the range of protein nanostructures potentially available for various molecular machine systems is significantly larger than the range of such structures already exploited by natural selection.