Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.
Archive for the 'Research' Category
Advances in the de novo design of coiled-coil proteins made by two different research groups proceeding by two different routes demonstrate that the range of protein nanostructures potentially available for various molecular machine systems is significantly larger than the range of such structures already exploited by natural selection.
Painting atomically precise carbon nanotubes onto a cathode produces flat panel lights a hundred times more energy efficient than LEDs.
A general framework is presented for using 32-nucleotide DNA bricks to build large two-dimensional crystals up to 80 nm thick and incorporating sophisticated three-dimensional features.
Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.
A phosphorescent molecule is made to flap like a butterfly when absorbed light shortens the distance between two platinum atoms.
The need for improved imaging and characterization on the nanoscale was emphasized in the 2007 Roadmap and again at the 2013 Foresight Conference on Atomic Precision. We noted last year a new advancement in atomic-scale resolution of 10-nm platinum particles, requiring multiple imaging techniques in combination, and recently the marked improvement in optical imaging for [...]
To emulate the process by which nature assembles complex organic molecules by passing subunits through a series of enzyme domains, UK chemists developed a procedure to elongate a boronic ester by using a reagent that inserts into carbon-boron bonds with precise control of molecular configuration.
A 10-fold larger breadboard and 350-fold lower DNA synthesis costs make DNA origami a more useful stepping-stone toward atomically precise manufacturing.
A nanoparticle that self-assembles from porphyrin, cholic acid, amino acids, and polyethylene glycol is a promising vehicle for delivering both imaging agents and cancer drugs to tumors.
Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.
Attaching a 200-nm-diameter magnetic bead to a 1-nm diameter synthetic molecular machine allowed optical visualization of the motion of the machine and manipulation with a magnetic tweezers.
Photovoltaics are an interesting case where atomic precision is not necessary to achieve potentially dramatic global impacts. Even an “ok efficiency” device that is easy to manufacture with reduced environmental hazard could have significant beneficial effects on energy resources and on device fabrication processes (which could, in turn, contribute to developments toward APM). The struggle [...]
Rice University’s breakthrough nanoporous silicon oxide technology for resistive random-access memory (RRAM) appears poised for commercialization.
Using an STM to precisely position indium adatoms on an indium arsenide surface, nanotechnologists have created a series of atomically precise quantum dots, and joined them with atomic precision to make quantum dot molecules, opening new avenues to construct practical quantum devices for computing and other applications.
Enveloped DNA nanostructures were developed to escape attacks from nucleases and the immune system, opening a path to ever more sophisticated DNA nanomedical devices.
The complex molecular recognition code of RNA offers RNA nanotechnology a greater variety of 3D structures and functions than are present in DNA nanotechnology, but the RNA structures can be fragile. New RNA triangles that resist boiling solve this problem.
Carbon-containing functional groups decorating carbon nanotubes decompose upon heating on copper foil to form a nanotube-reinforced graphene with novel properties that mimic those of expensive indium-tin-oxide.
A swinging DNA arm added to a DNA scaffold makes it possible for two enzymes attached to the scaffold to complete a coupled chemical reaction.
A bacterium has been engineered to stably propagate a DNA written with six letters instead of the usual four, greatly expanding the number of amino acids, both natural and synthetic, that can be genetically encoded. Further work could lead to novel proteins incorporating these additional amino acids, and from there to novel materials, devices, and machines.