A very large community of online gamers has consistently produced RNA designs that outperform the best design algorithms by a large margin. Can online gamers designing RNA, protein, and other molecules contribute to the development of atomically precise manufacturing?
Archive for the 'Research' Category
A reconstituted high-density lipoprotein nanoparticle reduces inflammation in advanced atherosclerotic plaques in mice. Will it work in humans to prevent repeat heart attacks and stroke?
A DNA clamp engineered for higher specificity and higher affinity may improve cancer diagnosis and treatment and may also mean better control over building nanomachines.
A possible forerunner to a future molecular assembly line uses an artificial DNA motor to transport an artificial nanoparticle along a carbon nanotube track.
A study of RNA structures actually present in cells reveals that cells spend energy restricting thermodynamically driven RNA folding so that fewer RNA structures are found in cells than in test tubes.
Design and prediction are integral to Atomically Precise Manufacturing and its development. This is in part because fully functional APM can be readily explored computationally today, to levels of precision that cannot be experimentally developed today. In such a context, design is not just a resource but an approach. With rapidly expanding computational power, examples [...]
At the 2013 Conference Philip Moriarty presented non-contact Atomic Force Microscope experiments demonstrating mechanical toggling of silicon dimers on a silicon surface. The crucial role of precise control of probe tip structure was emphasized.
Using DNA nanotechnology to control and organize molecular motors and the molecular tracks that they run on, a novel nanotrain transports molecular cargos tens of micrometers.
A nanoribbon transistor no thicker than the distance between adjacent DNA bases provides high resolution sensing of DNA passage through nanopores, perhaps leading eventually to rapid DNA sequencing.
Gold nanoparticles densely coated with RNA molecules intended to silence a gene essential for an incurable brain cancer proved effective in mice engrafted with human glioblastoma multiforme tumor.
Modifying DNA strands with lipid-like molecules opens more possibilities for designing DNA structures for drug delivery and other purposes.
Nymphs of certain jumping insects have evolved 400-micrometer mechanical gear strips to precisely synchronize legs when jumping.
Carbyne – a straight line of carbon atoms linked by double bonds or by alternating single and triple bonds — is the next stiff, carbon-based structure with unusual and desirable properties. It has been observed under limited natural and experimental conditions, is expected to be difficult to synthesize and store, and now has been theoretically [...]
Materials scientists have pursued the question of why vertically aligned carbon nanotube forests show much lower modulus values than expected. Now researchers from Georgia Tech have found that the nanotubes they fabricate contain kinks that dramatically diminish modulus value. In other words, the nanotubes are not straight; therefore, they are not stiff. The government-funded research [...]
A major advance in the computational design of proteins that bind tightly to specific small molecules will facilitate several technologies, possibly including the development of atomically precise manufacturing.
How complex could circuits be made using precisely positioned DNA nanostructures as templates to grow graphene nanoribbons?
“Molecular threading”, a nanotechnology developed by Halcyon Molecular and now owned by Aeon Biowares, enables precise placement of individual long molecules of DNA, either for sequencing or for nanofabrication of novel DNA nanostructures.
At the 2013 Conference the winner of the 2011 Feynman Prize for Experimental work presents STM studies showing how the manipulation of single molecules on a surface can yield insights to their mechanical, electronic, and optical properties, and be used in a controlled way to build pre-defined molecular architectures.
The Conference to be held February 7-9, 2014 in Palo Alto, California will emphasize the integration of nano-engineered devices and materials into larger, more complex systems.
Graphene molecules a bit more than one nanometer across and greatly distorted from planarity have altered properties and offer novel building blocks for nanotechnology.