A review from the group leading recent rapid progress in de novo protein design describes the successes, identifies the remaining challenges, and heralds the advance “from the Stone Age to the Iron Age” in protein design.
Archive for the 'Research' Category
Ten designs spanning three types of icosahedral architectures produce atomically precise multi-megadalton protein cages to deliver biological cargo or serve as scaffolds for organizing various molecular functions.
Atomically precise chevron-shaped graphene nanoribbons were purified after solution synthesis, cleanly placed by dry contact transfer on a hydrogen-passivated Si surface, imaged and manipulated by scanning tunneling microscopy, and covalently bonded to depassivated surface positions.
Computational recombination of small elements of structure from known protein structures generates a vast library of designs that balance protein stability with the potential for new functions and novel interactions.
Computer designed networks of hydrogen bonds allow programming specific interactions of protein interfaces, facilitating programming molecular recognition.
Removing the necessity of providing several different chemical fuels in a series of distinct steps, a novel chemically-fueled molecular motor autonomously produces movement as long as the fuel supply lasts.
Recent research documents a structure-based rational design strategy combining molecular dynamics and single molecule imaging to improve the performance of a DNA tweezers that accurately positions an enzyme and its cofactor.
Precise matching of STM images and theoretical calculations provides exact lattice locations of dopant atoms, advancing the prospects for silicon-based quantum computers.
Combining computational nanotechnology with a noncontact-atomic force microscope probe tipped by a single CO molecule allowed researchers to visualize the dance of individual chemical bonds during a complex organic reaction on a silver surface.
Chains of monomers joined by non-biological peptoid bonds follow different rules of self-assembly and form structures not found in chains joined by the peptide bonds used to form proteins.
An engineered protein controls the assembly of C60 fullerene molecules into an atomically precise lattice that conducts electricity while neither component alone would.
The claim that the recently reported actuating nanotransducers (ANTS) produce forces “orders of magnitude larger than any produced previously” is challenged by a nanocrystal carbon nanotube device reported 11 years ago.
Atomic resolution measurement of quasi-particle tunneling maps of spin-resolved states reveals interference processes that allow simulation of processes important for developing quantum computers based on atomically precise doping of silicon.
Computational design of an enzyme that carboligates three one-carbon molecules to form one three-carbon molecule, an activity that does not exist in nature, provides proof-of-principle for a novel metabolic pathway for carbon fixation.
A nanoengine 100 times more powerful than known nanomotors and muscles was demonstrated using the aggregation and dispersal of gold nanoparticles coated with a polymer that undergoes a rapid transition from hydrophobic to hydrophilic.
A DNA strand capable of forming a triple helix with a portion of the DNA double helices in a macroscopic DNA crystal enhances the weak interactions holding the crystal together so that the crystal remains stable in the absence of a high ionic strength environment.
A specially designed triplex forming oligonucleotide bearing a cargo molecule binds to a specific sequence in the major groove of a DNA double helix to form a modified DNA tile that self assembles into a macroscopic crystal in which each helix carries a cargo molecule positioned to sub-nanometer precision.
Structural DNA nanotechnology: progress toward a precise self-assembling three dimensional scaffold by building macroscopic crystals from nanoscale structures.
Five calcium ions held several micrometers apart in an ion trap and manipulated by laser pulses implement Shor’s factorization algorithm more efficiently than previous implementations.
Small, stiff, rectangular rods made using scaffolded DNA origami bypass drug resistance mechanisms in the membranes of a cultured leukemia cell line and release enough therapeutic drug to kill the cancer cell.