RNA interference provides potential cures for various diseases by silencing the expression of specific genes in specific organs, but delivering the RNA molecules to the right place is very difficult. A novel nanoparticle provides unprecedented efficiency in silencing target genes in liver cells.
Archive for the 'Research' Category
A possible top-down path to atomically precise manufacturing that passes through microscale machinery might be rendered easier because of recent progress in suppressing the Casimir force, which contributes to the ‘stiction’ problem often encountered with microelectromechanical systems.
Pioneering a design and fabrication strategy to address individual nanoscale electronic devices to enable large-scale assembly into integrated computer circuits, a MITRE-Harvard team has assembled a functional nanoelectronic control computer.
Using struts made of DNA to stiffen polyhedral corners, scientists have build rigid DNA cages an order of magnitude larger than previous DNA nanostructures, and only one order of magnitude smaller than bacterial cells.
A new tool to chemically modify one specific carbon atom among several chemically very similar ones will facilitate building larger, more complex molecules for drug discovery and for nanotechnology.
A very large community of online gamers has consistently produced RNA designs that outperform the best design algorithms by a large margin. Can online gamers designing RNA, protein, and other molecules contribute to the development of atomically precise manufacturing?
A reconstituted high-density lipoprotein nanoparticle reduces inflammation in advanced atherosclerotic plaques in mice. Will it work in humans to prevent repeat heart attacks and stroke?
A DNA clamp engineered for higher specificity and higher affinity may improve cancer diagnosis and treatment and may also mean better control over building nanomachines.
A possible forerunner to a future molecular assembly line uses an artificial DNA motor to transport an artificial nanoparticle along a carbon nanotube track.
A study of RNA structures actually present in cells reveals that cells spend energy restricting thermodynamically driven RNA folding so that fewer RNA structures are found in cells than in test tubes.
Design and prediction are integral to Atomically Precise Manufacturing and its development. This is in part because fully functional APM can be readily explored computationally today, to levels of precision that cannot be experimentally developed today. In such a context, design is not just a resource but an approach. With rapidly expanding computational power, examples [...]
At the 2013 Conference Philip Moriarty presented non-contact Atomic Force Microscope experiments demonstrating mechanical toggling of silicon dimers on a silicon surface. The crucial role of precise control of probe tip structure was emphasized.
Using DNA nanotechnology to control and organize molecular motors and the molecular tracks that they run on, a novel nanotrain transports molecular cargos tens of micrometers.
A nanoribbon transistor no thicker than the distance between adjacent DNA bases provides high resolution sensing of DNA passage through nanopores, perhaps leading eventually to rapid DNA sequencing.
Gold nanoparticles densely coated with RNA molecules intended to silence a gene essential for an incurable brain cancer proved effective in mice engrafted with human glioblastoma multiforme tumor.
Modifying DNA strands with lipid-like molecules opens more possibilities for designing DNA structures for drug delivery and other purposes.
Nymphs of certain jumping insects have evolved 400-micrometer mechanical gear strips to precisely synchronize legs when jumping.
Carbyne – a straight line of carbon atoms linked by double bonds or by alternating single and triple bonds — is the next stiff, carbon-based structure with unusual and desirable properties. It has been observed under limited natural and experimental conditions, is expected to be difficult to synthesize and store, and now has been theoretically [...]
Materials scientists have pursued the question of why vertically aligned carbon nanotube forests show much lower modulus values than expected. Now researchers from Georgia Tech have found that the nanotubes they fabricate contain kinks that dramatically diminish modulus value. In other words, the nanotubes are not straight; therefore, they are not stiff. The government-funded research [...]
A major advance in the computational design of proteins that bind tightly to specific small molecules will facilitate several technologies, possibly including the development of atomically precise manufacturing.