Small, stiff, rectangular rods made using scaffolded DNA origami bypass drug resistance mechanisms in the membranes of a cultured leukemia cell line and release enough therapeutic drug to kill the cancer cell.
Archive for the 'Research' Category
Thousands of amateurs playing the online RNA folding game Eterna, backed up by a real-world automated lab testing their predictions, have provided insights to improve the algorithms computers use to design RNA molecules.
A rotor with DNA origami parts held together by an engineered tight fit instead of by covalent bonds can revolve freely, driven by Brownian motion and dwelling at engineered docking sites.
Two research teams present two different methods for using single strands of DNA to link various nanoparticles into complex 3D arrays: one using DNA hairpins for dynamic reconfiguration and the other using a DNA origami scaffold.
A paradigm shift in analyzing diffraction from smaller, less perfect crystals yields improved resolution and enables directly determining the phase of the diffraction pattern.
Encapsulating enzymes in nanocages engineered using structural DNA nanotechnology increases enzymatic digestion and protects enzymes from degradation.
New families of protein structures, barrel proteins for positioning small molecules, self-assembling protein arrays, and precision sculpting of protein architectures highlight de novo protein design advances.
Computational design of proteins satisfying predetermined geometric constraints produced stable proteins with the designed structure that are not found in nature.
A fully automated design protocol generates dozens of designs for proteins based on helix-loop-helix-loop repeat units that are very stable, have crystal structures that match the design, have very different overall shapes, and are unrelated to any natural protein.
Prof. William Goddard presented four advances from his research group that enable going from first principles quantum mechanics calculations to realistic nanosystems of interest with millions or billions of atoms.
DNA building blocks mimic biological ion channels to more precisely control which molecules can cross a biological membrane.
A molecular robotic arm synthesized from small synthetic organic molecules uses cyclic changes in pH and other reaction conditions to grab and release a cargo molecule, and swing the cargo back and forth between the two ends of the molecular platform.
The positions of 3769 tungsten atoms in a tungsten needle segment were determined to a precision of 19 pm (0.019 nm), including the position of a single atom defect in the interior of the sample, by using aberration-corrected scanning transmission electron microscopy and computerized tomography.
In the first mouse model of the progressive form of multiple sclerosis, nanoparticles that created immune tolerance to myelin prevented the development of progressive MS.
Highly correlated electron motions resembling electron liquids rather than electron gases, and found in some transition metal oxides, may enable inexpensive substitution for expensive displays.
Electrochemically modifying individual metallic nanoparticles and pairs of such nanoparticles enabled reversible tuning of their optical properties, including charge transfer plasmon formation in nanoparticle pairs.
Coating micrometer-sized glass spheres with hundreds of DNA strands complementary to an RNA covering a glass slide enables the sphere to move, with the help of an enzyme that digests RNA bound to complementary DNA, a thousand times faster than conventional DNA-walkers.
Eight-armed nanoparticles of gold coated with a gold-palladium alloy proved to be both efficient plasmonic sensors and efficient catalysts, even though gold alone is not normally a good catalyst and palladium is a poor plasmonic material.
Two microRNAs with synergistic effects, one that suppresses tumor growth and another than inhibits tumor promotion, are combined in an RNA triple helix, complexed with a dendrimer to form nanoparticles, which are incorporated with a polymer to form a hydrogel that inhibits tumor growth when applied to the tumor.
A nanotechnology-based sensor provides fast, inexpensive, ultrasensitive assay of microRNA pattern to detect cancer using DNA immobilized on a synthetic gold nanoprism.