Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.
Archive for the 'Research' Category
A rotaxane-based single molecule pump combines cycling oxidation-reduction potential of the solution with kinetic barriers to moving backward to concentrate small ring molecules against an energy gradient.
At the 2013 Conference Dean Astumian contrasted macroscopic machines at static equilibrium and molecular machines at dynamic equilibrium, and presented information ratchets and microscopic reversibility as the organizing principle of molecular machines.
At the 2013 Conference Gerhard Klimeck presented the work of his computational nanotechnology network modeling nanoelectronic devices, using simulations of multi-million atom domains to understand the function of single atom devices embedded in larger nanostructures.
DNA sequences designed to either stimulate a specific immune response or to down-regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.
A prototype system to produce chemicals and fuels from sequestered carbon dioxide, water, and sunlight uses semiconductor nanowires to produce electron-hole pairs, which are then used by two types of bacteria to produce oxygen and a variety of useful chemical products.
A new form of carbon produced by very slowly releasing benzene compressed at 200,000 times atmospheric pressure may be the strongest material possible.
Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.
The Theory Prize was given for research into diamond nanoparticles; the Experimental Prize was given for development of scanning tunneling microscope (STM) technology.
Single-molecule spectroscopy makes possible adding one rung at a time to a foundational rung grafted to a surface to make a long nanotube scaffold of predetermined sequence.
Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.
Design and computational simulation of amyloid proteins of diverse functions from diverse sources enable the self-assembly of proteins that could provide scaffolds for diverse applications.
RNA origami brings new dimensions to nucleic acid nanotechnology by exploiting the much greater variety of RNA structural motifs (compared to DNA) to do what cannot easily be done with DNA origami, like fold into predetermined nanostructures rapidly while being transcribed.
Iterative coupling, purification, and cyclization of a large collection of organic building blocks promises a vast array of complex small and medium sized molecules as candidates for drug discovery, catalysis, and nanotechnology.
In tests in a mouse model of advanced atherosclerosis, core-shell nanoparticles, composed of block copolymers and targeted to sites of inflammation and vascular injury, delivered a bioactive peptide that improved key properties of advanced plaques.
A commentary over at Gizmodo argues that ideas about molecular manufacturing that sounded like science fiction in 1986 now sound more like science fact.
Bulk nanoscale technologies were used to create three-segment nanowires of gold and nickel, and magnetic bearings of gold, nickel, and chromium. Combinations of DC and AC electric fields were used to assemble nanomotors that can spin at speeds up to 18,000r.p.m., and for up to 15 hours.
An overview of three decades of progress in DNA nanotechnology emphasizes bringing programmed motion to DNA nanostructures, including efforts to incorporate design principles from macroscopic mechanical engineering.
Mixing two different types of cylindrical nanoparticles causes them to reorganize into smaller spherical nanoparticles. A mechanism to release drugs only inside cells that internalize both types?
Computational simulations demonstrate that pentagonal tiling to give a variant of graphene based on pentagons rather than on hexagons is dynamically, thermally, and mechanically stable.