By forcing the geometry of the junctions upon which DNA nanotechnology depends, researchers have increased the collection of 2D and 3D structures that they can build to include wire frames and mesh structures.
Archive for the 'Research' Category
Researchers from UCLA’s California NanoSystems Institute and Northwestern University have combined multiple imaging techniques to produce high quality 3D images of platinum nanoparticles, allowing advanced visualization of atomic-scale structural defects (an important advancement over X-ray crystallography). The original 2012 work, published in Nature and posted by Jim Lewis here, used electron tomography to study 10-nm [...]
Nanoparticles decorated to avoid immune system recognition were tested in mice and shown to survive longer and deliver more imaging dye and drug to tumor cells.
The advent of new technologies is typically followed by new government regulation, and in the absence of data, fear-based reactionism can have far too much influence on policy. Quality research studies on real risks and impacts of nanoscale technologies can help lead to legitimate scientific consensus and appropriate regulation. Engineered nanoparticles draw particular attention, because [...]
Core-shell nanocapsules deliver a potent protein complex to the nucleus of cancer cells where it induces them to commit suicide, while the complex degrades harmlessly in the cytoplasm of normal cells.
Scanning probe manipulation of individual atoms and small molecules were amongst the early laboratory successes that helped bring broad scale attention to the feasibility and potential of nanoscale technologies, especially molecular fabrication. Basic manipulations of atoms and bonds by scanning probe have become familiar capabilities that follow similar protocols: the STM tip is precisely positioned [...]
A demonstration that most fundamental biological processes can be implemented in a test tube as efficiently as in live bacteria provides synthetic biology the tools to create a ‘new industrial revolution’, which may or may not lead to more general molecular manufacturing.
A small molecular machine based on a rotaxane molecule autonomously added three amino acids in a programmed order to a seed tripeptide to form a hexapeptide
Electrons from a scanning tunneling microscope tip turn a five-arm rotor connected via a single ruthenium atom bearing to a tripod anchoring the molecular motor to a gold surface.
A theoretical proposal for optical tweezers and an experimental optical focusing device both depend upon electromagnetic waves trapped and guided along metal-insulator interfaces. Will these advances provide tools for manipulating molecular building blocks?
In two different sets of experiments a German research group has shown that scaffolded DNA origami can be used to assemble complex structures with precise sub-nanometer positional control, and that constant temperature reaction can greatly increase yields and decrease production times.
One research group working with rotaxanes and another group working with carbon nanotubes have provided two very different solutions to the problem of producing motion via artificial muscles at different scales from the nano to the macro.
A study of a biological molecular machine has shown that the machine functions most effectively when it uses chemical bonds just barely strong enough to survive the power stroke of the machine.
A set of 32-nucleotide single strand DNA bricks was designed so that each can interact independently with four other DNA bricks so that sets of hundreds of bricks can self-assemble into arbitrarily complex 25-nm 3D shapes, each comprising 1000 8-base pair volume elements.
New time-resolved, high-energy Xray studies of mechanochemical (ball milling) reactions take another step toward reducing the gap between current and future machine-phase chemistry.
Five proteins were designed from scratch and found to fold into stable proteins as designed, proving the ability to provide ideal, robust building blocks for artificial protein structures.
A single-electron spin qubit on a phosphorous atom in a conventional silicon computer chip has been coherently manipulated, demonstrating the application of single atom nanotechnology to the development of a scalable platform for a quantum computer.
One possible pathway from current technology to advanced nanotechnology that will comprise atomically precise manufacturing implemented by atomically precise machinery is through adaptation and extension of the complex molecular machine systems evolved by biology. Synthetic biology, which engineers new biological systems and function not evolved in nature, is an intermediate stage along this path. An [...]
Researchers from Johns Hopkins and Northwestern Universities developed a set of shape-tunable DNA-copolymer nanoparticles that incorporate a fixed amount of DNA yet display as much as 1,680-fold difference in transfection efficiency in rat liver studies. The study may shed new light on the importance of shape in nanoparticle-based drug delivery and gene therapy.
Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.