An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.
Archive for the 'Research' Category
Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.
Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.
At the 2013 Conference Joseph Puglisi described how single molecule fluorescence techniques were used to study changes in the conformation and composition of the ribosome, a large biomolecular nanomachine, during the process of translation of genetic information.
Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.
A molecular ring shuttles back and forth between two positions on a molecular axle held rigidly inside a solid state molecular lattice made from a metal organic framework.
By precise control of several factors, uniform high-performance monolayers of the semiconductor MoS2 have been obtained and used to fabricate field-effect transistors.
Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.
Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.
At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.
Density functional theory calculations of the electronic properties of double-walled carbon nanotubes (DWCNTs) comprising two concentric zigzag tubes of different chiralities reveal complex effects upon the electronic band gap, identifying candidate combinations for diverse applications from transistors to macroscopic conducting wires.
A combination of techniques has made possible the expansion of problems that can be handled by first-principles molecular dynamics from a few hundred atoms to a very large system containing 32,768 atoms.
A very efficient and scalable method of completely removing metallic carbon nanotubes from mixtures of metallic and semiconducting carbon nanotubes produces arrays suitable for many applications and for studies of thin film transistors.
Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.
Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.
A rotaxane-based single molecule pump combines cycling oxidation-reduction potential of the solution with kinetic barriers to moving backward to concentrate small ring molecules against an energy gradient.
At the 2013 Conference Dean Astumian contrasted macroscopic machines at static equilibrium and molecular machines at dynamic equilibrium, and presented information ratchets and microscopic reversibility as the organizing principle of molecular machines.
At the 2013 Conference Gerhard Klimeck presented the work of his computational nanotechnology network modeling nanoelectronic devices, using simulations of multi-million atom domains to understand the function of single atom devices embedded in larger nanostructures.
DNA sequences designed to either stimulate a specific immune response or to down-regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.
A prototype system to produce chemicals and fuels from sequestered carbon dioxide, water, and sunlight uses semiconductor nanowires to produce electron-hole pairs, which are then used by two types of bacteria to produce oxygen and a variety of useful chemical products.