Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.
Archive for the 'Bionanotechnology' Category
Advances in the de novo design of coiled-coil proteins made by two different research groups proceeding by two different routes demonstrate that the range of protein nanostructures potentially available for various molecular machine systems is significantly larger than the range of such structures already exploited by natural selection.
A general framework is presented for using 32-nucleotide DNA bricks to build large two-dimensional crystals up to 80 nm thick and incorporating sophisticated three-dimensional features.
Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.
A new DARPA program seeks to bridge the gap from atoms to macroscale product manufacture in two steps, the first of which is from atoms to micrometer-scale feedstocks. DNA origami may be part of the solution.
A 10-fold larger breadboard and 350-fold lower DNA synthesis costs make DNA origami a more useful stepping-stone toward atomically precise manufacturing.
A nanoparticle that self-assembles from porphyrin, cholic acid, amino acids, and polyethylene glycol is a promising vehicle for delivering both imaging agents and cancer drugs to tumors.
Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.
Register by Sept. 5 to attend a Proposers Day webinar on either Sept. 9 or 11 to learn the technical objectives of DARPA’s new “Atoms to product: Aiming to make nanoscale benefits life-sized” program.
An interview with UK nanotechnologist Richard Jones argues that the surest and most efficient path to advanced nanomachine function will incorporate or mimic biomolecular nanomachinery rather than scaled down rigid conventional machinery.
Study shows more than 500 firms involved in nanobiotechnology, which is expected to soon triple in size. Research points to the importance of broad networks and deep collaborations.
With biotech fundamental to several paths to advanced nanotechnology, a way to do biotech experiments in the cloud offers small groups the chance to quickly test their ideas.
B.R.AI.N.S., Berkeley BioLabs, and Foresight Institute to build an open source biological parts repository and design and distribute a line of “How-to Build Biological Machines” educational kits.
Enveloped DNA nanostructures were developed to escape attacks from nucleases and the immune system, opening a path to ever more sophisticated DNA nanomedical devices.
The photos from the 2014 Foresight Technical Conference highlight entrepreneurial efforts in space, biotechnology, and life extension.
The complex molecular recognition code of RNA offers RNA nanotechnology a greater variety of 3D structures and functions than are present in DNA nanotechnology, but the RNA structures can be fragile. New RNA triangles that resist boiling solve this problem.
A swinging DNA arm added to a DNA scaffold makes it possible for two enzymes attached to the scaffold to complete a coupled chemical reaction.
A bacterium has been engineered to stably propagate a DNA written with six letters instead of the usual four, greatly expanding the number of amino acids, both natural and synthetic, that can be genetically encoded. Further work could lead to novel proteins incorporating these additional amino acids, and from there to novel materials, devices, and machines.
By targeting the protein that attaches a type of immune cell called neutrophils to blood vessel walls where they cause serious tissues damage, the neutrophils are released and returned to the circulation to resume their normal functions.
RNA interference provides potential cures for various diseases by silencing the expression of specific genes in specific organs, but delivering the RNA molecules to the right place is very difficult. A novel nanoparticle provides unprecedented efficiency in silencing target genes in liver cells.