By forcing the geometry of the junctions upon which DNA nanotechnology depends, researchers have increased the collection of 2D and 3D structures that they can build to include wire frames and mesh structures.
Archive for the 'Bionanotechnology' Category
Nanoparticles decorated to avoid immune system recognition were tested in mice and shown to survive longer and deliver more imaging dye and drug to tumor cells.
In this Forbes interview, contributor John Nosta introduces us to a teen worth watching: fifteen-year-old Jack Andraka, whose effort to design a nanotube-based sensor for pancreatic cancer detection was initially ignored. The interview taps into some aspects of how innovation occurs and the challenges of bringing new ideas to fruition – aspects which transcend age, [...]
A proposed large project to produce a dynamic map of the functional connectome of the human brain will require a convergence of neuroscience, biotechnology, nanotechnology, and computation, and may therefore spur the development of advanced nanotechnology leading to molecular manufacturing.
Core-shell nanocapsules deliver a potent protein complex to the nucleus of cancer cells where it induces them to commit suicide, while the complex degrades harmlessly in the cytoplasm of normal cells.
In a 47-minute interview Christine Peterson discusses the future that science and technology is bringing over the next few decades, and how to get involved to push the future in a positive direction.
An interview with Foresight Co-Founder and Past President Christine Peterson covering both the current state and the future prospects of nanotechnology is available on Youtube.
A demonstration that most fundamental biological processes can be implemented in a test tube as efficiently as in live bacteria provides synthetic biology the tools to create a ‘new industrial revolution’, which may or may not lead to more general molecular manufacturing.
In two different sets of experiments a German research group has shown that scaffolded DNA origami can be used to assemble complex structures with precise sub-nanometer positional control, and that constant temperature reaction can greatly increase yields and decrease production times.
A study of a biological molecular machine has shown that the machine functions most effectively when it uses chemical bonds just barely strong enough to survive the power stroke of the machine.
A set of 32-nucleotide single strand DNA bricks was designed so that each can interact independently with four other DNA bricks so that sets of hundreds of bricks can self-assemble into arbitrarily complex 25-nm 3D shapes, each comprising 1000 8-base pair volume elements.
Five proteins were designed from scratch and found to fold into stable proteins as designed, proving the ability to provide ideal, robust building blocks for artificial protein structures.
One possible pathway from current technology to advanced nanotechnology that will comprise atomically precise manufacturing implemented by atomically precise machinery is through adaptation and extension of the complex molecular machine systems evolved by biology. Synthetic biology, which engineers new biological systems and function not evolved in nature, is an intermediate stage along this path. An [...]
Researchers from Johns Hopkins and Northwestern Universities developed a set of shape-tunable DNA-copolymer nanoparticles that incorporate a fixed amount of DNA yet display as much as 1,680-fold difference in transfection efficiency in rat liver studies. The study may shed new light on the importance of shape in nanoparticle-based drug delivery and gene therapy.
Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.
Optimizing the size and charge of nanoparticles engineered from polymers delivers drugs directly to mitochondria, effectively treating cells with drugs for a variety of diseases.
A “cut and paste” method uses an atomic force microscope to assemble protein and DNA molecules to form arbitrarily complex patterns on a surface. Developing this approach to form enzymatic assembly lines could be a path toward a general purpose nanofactory.
A combination of theoretical and experimental work on peptoids, synthetic analogs of proteins, points to the ability to design peptoids with desired structures and functions.
Studies in mice with otherwise fatal blood clots have shown that targeting a clot-busting drug to regions where blood flow is blocked restores circulation and increases survival with a much lower, safer dose of the drug.
Computational insights into a fundamental organic synthesis reaction may lead to the ability to design a catalyst for any desired reaction.