Foldit game players have again out-performed scientists in protein design, this time improving the design of a protein designed from scratch to catalyze Diels-Alder cycloadditions.
Archive for the 'Productive Nanosystems' Category
An article in The Guardian quotes Christine Peterson and Robert Freitas on the vision of molecular manufacturing. Freitas is quoted as expecting that the development of nanofactories could be done in 20 years for “on the order of” one billion dollars.
A four-step unidirectional molecular motor driven by light and temperature changes catalyzes different chemical reactions at different steps of its rotary cycle.
A tutorial review available after free registration presents a theory-based exploration of the difficulty in moving from simple molecular switches to arrays of artificial molecular machines capable to doing substantial, useful external work.
RNA CAD tools developed for RNA-regulated control of gene expression in synthetic biology successfully engineered metabolic pathways in bacteria. Will engineering RNA-based genetic control systems lead to design tools for other RNA-based molecular machine systems?
A tutorial review addresses the distinction between the many simple artificial molecular devices that are currently available and truly effective artificial molecular machines that would mimic the ubiquitous molecular machines present in living systems.
In a lecture at Oxford Eric Drexler argued that atomically precise manufacturing will be the next great revolution in the material basis of civilization, and discussed how we can establish reliable knowledge about key aspects of such technologies.
The oscillating synthesis and degradation of regulatory RNA molecules was used to produce a molecular clock to control the opening and closing of a DNA tweezers, and also to control the production of another RNA molecule to alter the fluorescence of a dye molecule.
Tiles made from DNA helices have been made to self-assemble into a more complex structure, which then was used to seed the formation of a complementary structure. This second structure in turn seeded the formation of multiple copies of the first structure.
Engineered bacteria that incorporate unnatural amino acids at multiple positions provide a new tool that may facilitate designing proteins to fold more predictably into molecular machinery components.
Ultrasound was used to pull on polymer chains attached to opposite sides of a chemically almost inert molecular ring, splitting it into its two components.
News articles by Jon Cartwright on the Chemistry World news site and by Michael Berger at Nanowerk describe a significant molecular machine milestone achieved by the research groups of David A. Leigh (winner of the 2007 Foresight Institute Feynman Prize in Nanotechnology for Theory) and Anne-Sophie Duwez. The research was reported in Nature Nanotechnology [abstract]. [...]
A green nanotechnology roadmap released by the American Chemical Society describes the opportunities and barriers to developing commercial applications of nanomaterials that present little threat of harm to health and the environment, and concludes with an action agenda to more forward.
Submit your own work or nominate a colleague for the 2011 Foresight Institute Feynman Prizes.
Will an inexpensive automated evolution machine accelerate the development of molecular machine systems by simultaneously evolving multiple parts to improve function?
New computational method screens for small molecules that bind to RNA molecules that move through a variety of conformations.
We’re going to take a shot at doing a live webcast of Foresight@Google: 25th Anniversary Conference and Celebration. See this page for schedule and link: http://foresight.org/reunion/schedule.html It’s free so please have patience if we run into any technical difficulties. You can try sending questions to speakers by using this Twitter tag (though in-person participants get first [...]
A new book collects the papers and discussions from the 2007 Solvay Conference “From Noncovalent Assemblies to Molecular Machines”.
I. Foresight@Google: Registration Deadline – Wed June 22nd II. Open Foresight Reception in Palo Alto – Friday June 24th III. Senior Associates Reunion Banquet – Saturday June 25th IV. Thiel Foundation’s 20Under20 to attend Foresight@Google ================================== I. Foresight@Google Registration Deadline – Wednesday June 22nd Foresight@Google – June 24-26, 2011 25th Anniversary Conference Celebration & Reunion Weekend [...]
Does the recent discovery that quantum tunneling controls a chemical reaction of a carbene complicate theoretical studies of nanotechnology, especially of diamond mechanosynthesis?