A review from the group leading recent rapid progress in de novo protein design describes the successes, identifies the remaining challenges, and heralds the advance “from the Stone Age to the Iron Age” in protein design.
Archive for the 'Artificial Molecular Machines' Category
Sir J. Fraser Stoddart, winner of 2007 Foresight Feynman Prize for Experiment, shares the 2016 Chemistry Nobel for the design and synthesis of molecular machines.
Removing the necessity of providing several different chemical fuels in a series of distinct steps, a novel chemically-fueled molecular motor autonomously produces movement as long as the fuel supply lasts.
Recent research documents a structure-based rational design strategy combining molecular dynamics and single molecule imaging to improve the performance of a DNA tweezers that accurately positions an enzyme and its cofactor.
The claim that the recently reported actuating nanotransducers (ANTS) produce forces “orders of magnitude larger than any produced previously” is challenged by a nanocrystal carbon nanotube device reported 11 years ago.
A nanoengine 100 times more powerful than known nanomotors and muscles was demonstrated using the aggregation and dispersal of gold nanoparticles coated with a polymer that undergoes a rapid transition from hydrophobic to hydrophilic.
A rotor with DNA origami parts held together by an engineered tight fit instead of by covalent bonds can revolve freely, driven by Brownian motion and dwelling at engineered docking sites.
Polymer chemistry and materials research provide opportunities to explore structures that harmonize phenomena unique to nanoscale technology, the role of mechanical forces generated at interfaces, and the responses of biological systems to mechanical stresses.
A molecular robotic arm synthesized from small synthetic organic molecules uses cyclic changes in pH and other reaction conditions to grab and release a cargo molecule, and swing the cargo back and forth between the two ends of the molecular platform.
German researchers have used scaffolded DNA origami to adjust the angle of a DNA hinge joint by altering the length of special “adjuster helices”, causing molecules attached to the sides of the hinge to be displaced by as little as 0.04 nm.
Each time a laser pulse actuates the cis-trans isomerization of a single carbon-carbon double bond, a single-molecule nanosubmarine made of 244 atoms is driven forward 9 nm against Brownian diffusion.
Independent rotation of two wheels attached to either end of an axle has been achieved in a light-driven artificial molecular motor, suggesting a basis for a nanometer-scale transport system.
DNA nanotechnology produces an artificial molecular machine that changes shape when it encounters a specific antibody or other protein molecule, and emits light to signal the target’s presence.
Designing a small DNA origami that can fold in several almost equivalent ways demonstrates how understanding and guiding the folding pathway can improve the efficiency of the folding process, potentially leading in more complex situations to higher yields of the desired nanostructure and fewer misfolded structures.
An extensive review of artificial molecular machines, their large-amplitude motions, and the changes these motions produce, emphasizes small molecules and the central role of chemistry in their design and operation.
Simple molecular switches based upon bistable mechanically interlocked molecules can be incorporated within pre-assembled metal organic frameworks and addressed electrochemically.
A review of molecular parts that act as switches, motors, and ratchets illuminates similarities between artificial and biological molecular machines and argues that useful applications are coming.
A pliers-shaped molecule in which two covalently linked naphthalene moieties serve as the hinge connecting the two halves of the pliers, and each naphthalene connects the hydrophobic handle with the hydrophilic jaw of that half, opens and closes in response to surprisingly little energy applied to a molecular monolayer.
Modeling DNA strand displacement cascades according to three simple rules can in principle mimic the temporal dynamics of any other chemical system, presenting a method to model regulatory networks even more complicated than those of biology.
Functional ribosomes with subunits engineered to not separate at the completion of each protein translation cycle make possible engineering systems to make a variety of novel polymers with novel properties.