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Archive for the 'Nanobiotechnology' Category

Nanotechnology provides sensors for liver-on-chip drug testing

Posted by Jim Lewis on September 2nd, 2015

Adding nanotechnology-based optoelectronic sensors to human cells cultured on a chip keeps the cells healthy long enough to replace animal testing with a human liver-on-a-chip.

Novel wireframe nanostructures from new DNA origami design process

Posted by Jim Lewis on August 18th, 2015

A new set of design rules enables constructing any wireframe nanostructure, which may lead to new medical applications and new nanomachines.

Conference video: Artificial Biochemistry with DNA

Posted by Jim Lewis on August 13th, 2015

Modeling DNA strand displacement cascades according to three simple rules can in principle mimic the temporal dynamics of any other chemical system, presenting a method to model regulatory networks even more complicated than those of biology.

Ribosome subunits tethered to make versatile artificial molecular machine

Posted by Jim Lewis on August 11th, 2015

Functional ribosomes with subunits engineered to not separate at the completion of each protein translation cycle make possible engineering systems to make a variety of novel polymers with novel properties.

Automated design of polyhedral meshes for DNA origami

Posted by Jim Lewis on August 7th, 2015

An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.

Arranging molecular chromophores on DNA brick nanobreadboards

Posted by Jim Lewis on August 6th, 2015

Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.

Facilitating structural DNA nanotechnology with non-aqueous solvents

Posted by Jim Lewis on August 2nd, 2015

Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.

Foresight co-sponsors Berkeley Bench to Market event

Posted by Jim Lewis on July 30th, 2015

To educate potential entrepreneurs on strategies for moving discoveries from the benchtop to successful commercialization, Foresight co-sponsored an event in the “Ph.D. to Startup” Workshop Series of the Berkeley Postdoc Entrepreneur Program.

Foresight 1999 Distinguished Student wins Galactic Grant Competition

Posted by Jim Lewis on July 28th, 2015

Technology developed by Nanobiosym, founded by Anita Goel, to enable personalized diagnostic testing won the Grand Prize of the Nokia Sensing XCHALLENGE in 2013, and this month was awarded the top prize in the Galactic Grant Competition.

Conference video: Conformational and compositional dynamics of a molecular machine

Posted by Jim Lewis on July 8th, 2015

At the 2013 Conference Joseph Puglisi described how single molecule fluorescence techniques were used to study changes in the conformation and composition of the ribosome, a large biomolecular nanomachine, during the process of translation of genetic information.

Linking together small DNAs to build more diverse DNA nanostructures

Posted by Jim Lewis on July 2nd, 2015

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

DNA nanomachines more stable than expected in human serum and blood

Posted by Jim Lewis on June 29th, 2015

Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.

Conference video: Regenesis: Bionano

Posted by Jim Lewis on June 9th, 2015

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Dynamic nanomachines for DNA nanotechnology inspired by proteins

Posted by Jim Lewis on June 4th, 2015

Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.

Preserving protein function in DNA-protein nanostructures

Posted by Jim Lewis on June 1st, 2015

Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.

Conference video: Microscopic Reversibility: The Organizing Principle for Molecular Machines

Posted by Jim Lewis on May 13th, 2015

At the 2013 Conference Dean Astumian contrasted macroscopic machines at static equilibrium and molecular machines at dynamic equilibrium, and presented information ratchets and microscopic reversibility as the organizing principle of molecular machines.

Nanoparticles shepherd DNA into cells to regulate immune response

Posted by Jim Lewis on May 6th, 2015

DNA sequences designed to either stimulate a specific immune response or to down-regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.

Gold nanotubes engineered for diagnosis and therapy

Posted by Jim Lewis on April 30th, 2015

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

Solid-phase synthesis of custom-made DNA nanotubes

Posted by Jim Lewis on April 9th, 2015

Single-molecule spectroscopy makes possible adding one rung at a time to a foundational rung grafted to a surface to make a long nanotube scaffold of predetermined sequence.

DNA nanoswitches open window on molecular interactions

Posted by Jim Lewis on April 5th, 2015

Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.