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Archive for the 'Nanobiotechnology' Category

Shape may play an important role in nanoparticle-based therapeutics

Posted by Stephanie C on October 19th, 2012

Researchers from Johns Hopkins and Northwestern Universities developed a set of shape-tunable DNA-copolymer nanoparticles that incorporate a fixed amount of DNA yet display as much as 1,680-fold difference in transfection efficiency in rat liver studies. The study may shed new light on the importance of shape in nanoparticle-based drug delivery and gene therapy.

Biological molecular motors programmed to run DNA chasis

Posted by Jim Lewis on October 17th, 2012

Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.

Nanoparticles deliver cargo inside mitochondria

Posted by Jim Lewis on October 9th, 2012

Optimizing the size and charge of nanoparticles engineered from polymers delivers drugs directly to mitochondria, effectively treating cells with drugs for a variety of diseases.

Assembling biomolecular nanomachines: a path to a nanofactory?

Posted by Jim Lewis on October 4th, 2012

A “cut and paste” method uses an atomic force microscope to assemble protein and DNA molecules to form arbitrarily complex patterns on a surface. Developing this approach to form enzymatic assembly lines could be a path toward a general purpose nanofactory.

Rational design of peptoids: a route to advanced nanotechnology?

Posted by Jim Lewis on September 7th, 2012

A combination of theoretical and experimental work on peptoids, synthetic analogs of proteins, points to the ability to design peptoids with desired structures and functions.

Shear-activated nanoparticles may target blood clots

Posted by Jim Lewis on August 16th, 2012

Studies in mice with otherwise fatal blood clots have shown that targeting a clot-busting drug to regions where blood flow is blocked restores circulation and increases survival with a much lower, safer dose of the drug.

Toward a method to design any needed catalyst?

Posted by Jim Lewis on August 6th, 2012

Computational insights into a fundamental organic synthesis reaction may lead to the ability to design a catalyst for any desired reaction.

Artificial evolution of enzymes to make novel semiconductors

Posted by Jim Lewis on August 3rd, 2012

The directed, artificial evolution of genes for enzymes that produce nanoparticles of silicon dioxide and titanium dioxide produced semiconductor structures not seen in nature.

Nanozyme destroys virus in human cells and in mice

Posted by Jim Lewis on July 30th, 2012

Nanotechnology combines an enzyme and a DNA molecule on the surface of gold nanoparticles to destroy hepatitis C virus in human cells and in a mouse model of disease.

New online game to design RNA molecules: advancing nanotechnology?

Posted by Jim Lewis on July 16th, 2012

A new online game allows players to design RNA molecules. The most promising designs are synthesized, and the players given real-world feedback on how well their designs worked.

Atomically precise nanoparticle provides better drug delivery

Posted by Jim Lewis on July 10th, 2012

Nanoparticles made from specific DNA and RNA strands, homogeneous in size, composition, and surface chemistry, proved superior to other nanoparticles in silencing gene expression in tumors in mouse experiments.

Nanotechnology and the rest of the universe

Posted by Jim Lewis on July 4th, 2012

A forest of long DNA strands hanging at known positions from a thin gold foil may provide a method to detect hypothetical particles of dark matter, thought to compose 26% of the universe.

An expanded genetic alphabet could lead to more easily designed proteins

Posted by Jim Lewis on June 22nd, 2012

The demonstration that the process of DNA replication is more flexible than thought should make it easier to incorporate unusual amino acids into designed proteins, which might make it easier to design novel protein machines.

Nanotechnology greatly improves sensitivity of common medical tests

Posted by Jim Lewis on June 21st, 2012

A new nanomaterial provides a three million-fold improvement in the sensitivity of common medical tests, potentially permitting earlier detection of cancer and Alzheimer’s disease.

New method to identify intermediates in protein folding

Posted by Jim Lewis on June 12th, 2012

Tryptophan residues introduced at various positions in a protein chain identify folding intermediates that are too short-lived to be structurally characterized otherwise.

Advancing nanotechnology with protein building blocks

Posted by Jim Lewis on June 6th, 2012

A variety of protein cage structures have been constructed by designing specific protein domains to self-assemble as atomically precise protein building blocks in defined geometries.

DNA tiles provide faster, less expensive way to fabricate complex DNA objects

Posted by Jim Lewis on May 31st, 2012

A set of 310 short single-stranded DNA tiles, plus a few additional short sequences for the edges, has been used to form more than a hundred large, complex DNA objects.

New Darpa program may accelerate synthetic biology path to advanced nanotechnology

Posted by Jim Lewis on May 26th, 2012

Darpa has launched a “Living Foundries” program to bring an engineering perspective to synthetic biology to greatly accelerate progress through standardization and modularization.

Foresight Presents: “GENOGEN: Regenerating Skin for Life”, with Dr. Nancy Mize

Posted by Jim Lewis on May 20th, 2012

Nancy K Mize, PhD, Scientist, Innovator, and CEO of GENOGEN Inc., will continue Foresight’s local Bay Area community events with a lecture “GENOGEN: Regenerating Skin for Life”. GENOGEN is developing products that activate resident skin stem cells to stimulate local areas of regeneration of skin naturally – the way children heal.

Drug-resistant cancer cells cannot resist plasmonic nanobubbles

Posted by Jim Lewis on May 13th, 2012

Nanoparticles targeted to cancer cells by antibodies cannot achieve enough specificity to kill drug-resistant cancer cells while sparing normal cells, but can achieve enough specificity to produce nanobubbles only in cancer cells, so the drug only enters cancer cells.