New computational methods to explore the rapidly expanding collection of high resolution three-dimensional RNA structures reveal new RNA structural motifs, identifying additional building blocks for complex RNA nanostructures.
Archive for the 'Nanobiotechnology' Category
Artist’s conception of a nanopore drilled into a layer of graphene to speed up DNA sequencing. One of the greatest promises of near-term nanotechnoloogy is cheaper DNA sequencing to speed the development of personalized medicine. There are not only genetic differences between different patients, but also genetic differences between, for example, different cancers of the [...]
Scientists at Kyoto University and the University of Oxford have combined DNA origami and DNA motors to take another step toward programmed artificial molecular assembly lines.
Foldit game players have again out-performed scientists in protein design, this time improving the design of a protein designed from scratch to catalyze Diels-Alder cycloadditions.
An article in The Guardian quotes Christine Peterson and Robert Freitas on the vision of molecular manufacturing. Freitas is quoted as expecting that the development of nanofactories could be done in 20 years for “on the order of” one billion dollars.
The first Master’s of Science in Nanomedicine degree program in US is announced. As an example of the rapidly developing potential of nanomedicine, a novel type of nanoparticle succeeded in two different mouse models in destroying a type of brain cancer that had previously been completely resistant to all treatment attempts.
A tutorial review available after free registration presents a theory-based exploration of the difficulty in moving from simple molecular switches to arrays of artificial molecular machines capable to doing substantial, useful external work.
RNA CAD tools developed for RNA-regulated control of gene expression in synthetic biology successfully engineered metabolic pathways in bacteria. Will engineering RNA-based genetic control systems lead to design tools for other RNA-based molecular machine systems?
Protein-like structures called peptoids can be formed into stable, free-floating nanosheets.
When can we expect advanced nanomachinery to be commercialized? Will any technologies not be affected in some way by advanced nanotechnology?
A tutorial review addresses the distinction between the many simple artificial molecular devices that are currently available and truly effective artificial molecular machines that would mimic the ubiquitous molecular machines present in living systems.
In a lecture at Oxford Eric Drexler argued that atomically precise manufacturing will be the next great revolution in the material basis of civilization, and discussed how we can establish reliable knowledge about key aspects of such technologies.
A new polymer that disintegrates in response to harmless radiation that can penetrate several inches into human tissue may lead to nanoparticles that release their drug cargo only at a desired time and place.
To counter the threat of evolved or engineered resistance of pathogenic bacteria to antibiotics, Darpa proposes to use nanotechnology to develop “Rapidly Adaptable Nanotherapeutics”.
Adding a new molecular recognition code to structural DNA nanotechnology—a pattern of projecting and recessed blunt-end DNA helices can be used to code the assembly of DNA origami tiles into larger DNA nanostructures.
Small DNA molecules fluoresce in the presence of specific transcription factors, sensing which genes are being expressed in that cell, potentially allowing cancer treatments to be personalized, and the quality of stem cells to be monitored.
This contribution has been forwarded by Ivo Rivetta. The primary forces on the nanometer scale are scaled versions of what we experience on a day to day basis. Instead of gravity, surface forces such as water tension and electric charge dominate. As an example, compare wet basketballs and wet sand. The weight of the basketballs [...]
The oscillating synthesis and degradation of regulatory RNA molecules was used to produce a molecular clock to control the opening and closing of a DNA tweezers, and also to control the production of another RNA molecule to alter the fluorescence of a dye molecule.
Yarn woven from carbon nanotubes provides a thousand times more rotation than is obtained from other artificial muscles, and could be made into motors to provide propulsion for micrometer-sized medical nanorobots.
Varying the length of the DNA used to connect the nanoparticles provides for a wide variety of nanoparticle sizes and crystal symmetries.