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Archive for the 'Nanobiotechnology' Category

Broadening the synthetic biology path to molecular nanotechnology

Posted by Jim Lewis on December 6th, 2014

Advances in the de novo design of coiled-coil proteins made by two different research groups proceeding by two different routes demonstrate that the range of protein nanostructures potentially available for various molecular machine systems is significantly larger than the range of such structures already exploited by natural selection.

Micrometer-scale structures built from DNA bricks

Posted by Jim Lewis on November 19th, 2014

A general framework is presented for using 32-nucleotide DNA bricks to build large two-dimensional crystals up to 80 nm thick and incorporating sophisticated three-dimensional features.

Using DNA nanotechnology to cast arbitrarily shaped nanoparticles

Posted by Jim Lewis on November 11th, 2014

Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.

DNA nanotechnology and the atoms to micrometer nanofabrication gap

Posted by Jim Lewis on September 26th, 2014

A new DARPA program seeks to bridge the gap from atoms to macroscale product manufacture in two steps, the first of which is from atoms to micrometer-scale feedstocks. DNA origami may be part of the solution.

Scaffolded DNA origami improvements advance DNA nanotechnology

Posted by Jim Lewis on September 25th, 2014

A 10-fold larger breadboard and 350-fold lower DNA synthesis costs make DNA origami a more useful stepping-stone toward atomically precise manufacturing.

Novel multifunctional nanoparticle for diagnosis and therapy

Posted by Jim Lewis on September 14th, 2014

A nanoparticle that self-assembles from porphyrin, cholic acid, amino acids, and polyethylene glycol is a promising vehicle for delivering both imaging agents and cancer drugs to tumors.

Proof of principle for nanoscale assembly line

Posted by Jim Lewis on September 2nd, 2014

Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.

DARPA announces new program on nanoscale assembly and integration

Posted by Jim Lewis on September 1st, 2014

Register by Sept. 5 to attend a Proposers Day webinar on either Sept. 9 or 11 to learn the technical objectives of DARPA’s new “Atoms to product: Aiming to make nanoscale benefits life-sized” program.

What kind of nanomachines will advanced nanotechnology use?

Posted by Jim Lewis on August 31st, 2014

An interview with UK nanotechnologist Richard Jones argues that the surest and most efficient path to advanced nanomachine function will incorporate or mimic biomolecular nanomachinery rather than scaled down rigid conventional machinery.

Emergence of nanobiotechnology points to importance of deep collaboration

Posted by Jim Lewis on August 8th, 2014

Study shows more than 500 firms involved in nanobiotechnology, which is expected to soon triple in size. Research points to the importance of broad networks and deep collaborations.

Biotech lab in the cloud lowers entry barrier to nanotech research

Posted by Jim Lewis on August 5th, 2014

With biotech fundamental to several paths to advanced nanotechnology, a way to do biotech experiments in the cloud offers small groups the chance to quickly test their ideas.

Building biological molecular machines as an open source path to advanced nanotechnology

Posted by Jim Lewis on July 24th, 2014

B.R.AI.N.S., Berkeley BioLabs, and Foresight Institute to build an open source biological parts repository and design and distribute a line of “How-to Build Biological Machines” educational kits.

Lipid coat protects DNA nanorobot from immune attack

Posted by Jim Lewis on July 5th, 2014

Enveloped DNA nanostructures were developed to escape attacks from nucleases and the immune system, opening a path to ever more sophisticated DNA nanomedical devices.

Photos from 2014 Foresight Technical Conference

Posted by Jim Lewis on June 24th, 2014

The photos from the 2014 Foresight Technical Conference highlight entrepreneurial efforts in space, biotechnology, and life extension.

Robust triangular RNA brick adds to RNA nanotechnology toolkit

Posted by Jim Lewis on June 24th, 2014

The complex molecular recognition code of RNA offers RNA nanotechnology a greater variety of 3D structures and functions than are present in DNA nanotechnology, but the RNA structures can be fragile. New RNA triangles that resist boiling solve this problem.

DNA nanotechnology replicates enzyme cascade

Posted by Jim Lewis on June 4th, 2014

A swinging DNA arm added to a DNA scaffold makes it possible for two enzymes attached to the scaffold to complete a coupled chemical reaction.

Expanded DNA alphabet provides more options for nanotechnology

Posted by Jim Lewis on May 14th, 2014

A bacterium has been engineered to stably propagate a DNA written with six letters instead of the usual four, greatly expanding the number of amino acids, both natural and synthetic, that can be genetically encoded. Further work could lead to novel proteins incorporating these additional amino acids, and from there to novel materials, devices, and machines.

To fight inflammation nanoparticles turn 'naughty' neutrophils into 'nice' neutrophils

Posted by Jim Lewis on May 1st, 2014

By targeting the protein that attaches a type of immune cell called neutrophils to blood vessel walls where they cause serious tissues damage, the neutrophils are released and returned to the circulation to resume their normal functions.

Novel nanoparticle efficiently silences gene expression in liver cells

Posted by Jim Lewis on April 29th, 2014

RNA interference provides potential cures for various diseases by silencing the expression of specific genes in specific organs, but delivering the RNA molecules to the right place is very difficult. A novel nanoparticle provides unprecedented efficiency in silencing target genes in liver cells.

US government report highlights flaws in US nanotechnology effort

Posted by Jim Lewis on April 1st, 2014

The concern of the US GAO for a gap in nanomanufacturing is well-placed, but it is only half of the problem with the limited US vision of the impact of nanotechnology on the future world economy.