A major advance in the computational design of proteins that bind tightly to specific small molecules will facilitate several technologies, possibly including the development of atomically precise manufacturing.
Archive for the 'Roadmaps' Category
In two different sets of experiments a German research group has shown that scaffolded DNA origami can be used to assemble complex structures with precise sub-nanometer positional control, and that constant temperature reaction can greatly increase yields and decrease production times.
Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.
Large molecular cages constructed from metal-organic frameworks have set a record for the greatest surface area in the least mass.
Metal-organic frameworks (MOFs) are back in the news again. A few months ago we cited the use of MOFs by Canadian chemists to self-assemble a molecular wheel on an axis in a solid material. More recently chemists at Northwestern University have used MOFs to set a world record for surface area. From “A world record for highest-surface-area materials“:
Northwestern University researchers have broken a world record by creating two new synthetic materials with the greatest amount of surface areas reported to date.
Named NU-109 and NU-110, the materials belong to a class of crystalline nanostructure known as metal-organic frameworks (MOFs) that are promising vessels for natural-gas and hydrogen storage for vehicles, and for catalysts, chemical sensing, light harvesting, drug delivery, and other uses requiring a large surface area per unit weight.
The materials’ promise lies in their vast internal surface area. If the internal surface area of one NU-110 crystal the size of a grain of salt could be unfolded, the surface area would cover a desktop. …
MOFs are composed of organic linkers held together by metal atoms, resulting in a molecular cage-like structure. The researchers believe they may be able to more than double the surface area of the materials by using less bulky linker units in the materials’ design. …
Beyond their near-term practical applications, Eric Drexler has cited MOFs as potentially useful building blocks in the molecular machine path to molecular manufacturing. Near-term applications may drive the technology development to produce more choices for molecular machine system components.
—James Lewis, PhD
A “cut and paste” method uses an atomic force microscope to assemble protein and DNA molecules to form arbitrarily complex patterns on a surface. Developing this approach to form enzymatic assembly lines could be a path toward a general purpose nanofactory.
Researchers in Australia and the US have demonstrated a working transistor by placing of single atom of phosphorous with atomic precision between gates made of wires only a few phosphorous atoms wide. This demonstration points to possibly extending current computer technology to the atomic scale.
Scientists at Kyoto University and the University of Oxford have combined DNA origami and DNA motors to take another step toward programmed artificial molecular assembly lines.
A tutorial review available after free registration presents a theory-based exploration of the difficulty in moving from simple molecular switches to arrays of artificial molecular machines capable to doing substantial, useful external work.
A tutorial review addresses the distinction between the many simple artificial molecular devices that are currently available and truly effective artificial molecular machines that would mimic the ubiquitous molecular machines present in living systems.
In a lecture at Oxford Eric Drexler argued that atomically precise manufacturing will be the next great revolution in the material basis of civilization, and discussed how we can establish reliable knowledge about key aspects of such technologies.
A green nanotechnology roadmap released by the American Chemical Society describes the opportunities and barriers to developing commercial applications of nanomaterials that present little threat of harm to health and the environment, and concludes with an action agenda to more forward.
A bacterial virus called M13 was genetically engineered to control the arrangement of carbon nanotubes, improving solar-cell efficiency by nearly one-third.
New software for scaffolded DNA origami makes it easier to predict what shape will result from a given DNA template.
Phage-assisted continuous evolution of proteins is roughly a hundred times faster than conventional laboratory evolution of proteins, perhaps speeding the development of components for molecular machine systems.
Using proprietary block co-polymer technology, directed self-assembly allows adding block co-polymers that assemble themselves into regular arrays on the surface of a silicon wafer that had been patterned using lithography.
Researchers in the UK and Japan use atomic force microscopy to visualize a DNA molecular robot moving along a 100-nm DNA track.
Here we present a special report from Dave Conz of ASU on Josh Hall’s talk and subsequent panel discussion at the SME nanotech conference. An excerpt: Technoscientific development is difficult to direct and nearly impossible to predict. Because of this – not in spite of it – panel discussions like “How Do We Get There [...]
PhysOrg.com brings news and a video of a new 3D patterning technique from IBM that reaches down to 15 nm resolution which “could go even smaller”: IBM Research in Zurich has demonstrated a new nanoscale patterning technique that could replace electron beam lithography (EBL). The demonstration carved a 1:5 billion scale three-dimensional model of the [...]
One of the species of early hominids is named Homo habilis, meaning “handy man,” after their significant advancement in tool use over previous hominids. One of the goals of the AGI Roadmap is to chart paths to full human intelligence, and one of the paths might follow the one that evolution took. The Wozniak Test, [...]
Foresight’s mission is essentially an educational one. In simplest terms we are here to point out foreseeable technological developments that not only will make the future different from the past, but make it different in ways that aren’t obvious and which everyone isn’t already planning for. Nanotechnology — true nanotech in Drexler’s original sense of [...]