A specially designed triplex forming oligonucleotide bearing a cargo molecule binds to a specific sequence in the major groove of a DNA double helix to form a modified DNA tile that self assembles into a macroscopic crystal in which each helix carries a cargo molecule positioned to sub-nanometer precision.
Archive for the 'Nanotechnology' Category
Structural DNA nanotechnology: progress toward a precise self-assembling three dimensional scaffold by building macroscopic crystals from nanoscale structures.
Five calcium ions held several micrometers apart in an ion trap and manipulated by laser pulses implement Shor’s factorization algorithm more efficiently than previous implementations.
Small, stiff, rectangular rods made using scaffolded DNA origami bypass drug resistance mechanisms in the membranes of a cultured leukemia cell line and release enough therapeutic drug to kill the cancer cell.
Increasing efficiency and utilization and lowering costs for harvesting, converting, transporting, and storing energy produced from sunlight provides a showcase for a variety of nanoscale materials, structures, and processes.
California Institute of Technology is holding a symposium to honor Paul Rothemund’s seminal contribution to the field of DNA nanotechnology: the research paths opened by the technology, and where they might lead.
Thousands of amateurs playing the online RNA folding game Eterna, backed up by a real-world automated lab testing their predictions, have provided insights to improve the algorithms computers use to design RNA molecules.
Do sophisticated medical applications of 3D printing, like printing titanium bones or human tissues, that portend wider use, also perhaps point toward eventual nanoscale applications as the technology improves?
A rotor with DNA origami parts held together by an engineered tight fit instead of by covalent bonds can revolve freely, driven by Brownian motion and dwelling at engineered docking sites.
Two research teams present two different methods for using single strands of DNA to link various nanoparticles into complex 3D arrays: one using DNA hairpins for dynamic reconfiguration and the other using a DNA origami scaffold.
A paradigm shift in analyzing diffraction from smaller, less perfect crystals yields improved resolution and enables directly determining the phase of the diffraction pattern.
Encapsulating enzymes in nanocages engineered using structural DNA nanotechnology increases enzymatic digestion and protects enzymes from degradation.
Polymer chemistry and materials research provide opportunities to explore structures that harmonize phenomena unique to nanoscale technology, the role of mechanical forces generated at interfaces, and the responses of biological systems to mechanical stresses.
New families of protein structures, barrel proteins for positioning small molecules, self-assembling protein arrays, and precision sculpting of protein architectures highlight de novo protein design advances.
Computational design of proteins satisfying predetermined geometric constraints produced stable proteins with the designed structure that are not found in nature.
A fully automated design protocol generates dozens of designs for proteins based on helix-loop-helix-loop repeat units that are very stable, have crystal structures that match the design, have very different overall shapes, and are unrelated to any natural protein.
Prof. William Goddard presented four advances from his research group that enable going from first principles quantum mechanics calculations to realistic nanosystems of interest with millions or billions of atoms.
Prof. Gerhard Klimeck described the success of nanoHUB.org, a science and engineering gateway providing online simulations through a web browser for nanotechnology research and education.
DNA building blocks mimic biological ion channels to more precisely control which molecules can cross a biological membrane.
A molecular robotic arm synthesized from small synthetic organic molecules uses cyclic changes in pH and other reaction conditions to grab and release a cargo molecule, and swing the cargo back and forth between the two ends of the molecular platform.