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Archive for the 'Nanomedicine' Category

Two-component, 120-subunit icosahedral cage extends protein nanotechnology

Posted by Jim Lewis on January 28th, 2017

Ten designs spanning three types of icosahedral architectures produce atomically precise multi-megadalton protein cages to deliver biological cargo or serve as scaffolds for organizing various molecular functions.

DNA nanotechnology defeats drug resistance in cancer cells

Posted by Jim Lewis on April 2nd, 2016

Small, stiff, rectangular rods made using scaffolded DNA origami bypass drug resistance mechanisms in the membranes of a cultured leukemia cell line and release enough therapeutic drug to kill the cancer cell.

DNA nanotechnology cages localize and optimize enzymatic reactions

Posted by Jim Lewis on February 16th, 2016

Encapsulating enzymes in nanocages engineered using structural DNA nanotechnology increases enzymatic digestion and protects enzymes from degradation.

DNA nanotechnology controls which molecules enter cells

Posted by Jim Lewis on January 13th, 2016

DNA building blocks mimic biological ion channels to more precisely control which molecules can cross a biological membrane.

Nanoparticles ameliorate MS in mice by inducing immune tolerance of myelin

Posted by Jim Lewis on January 7th, 2016

In the first mouse model of the progressive form of multiple sclerosis, nanoparticles that created immune tolerance to myelin prevented the development of progressive MS.

Rolling DNA-based motors increase nano-walker speeds 1000-fold

Posted by Jim Lewis on December 12th, 2015

Coating micrometer-sized glass spheres with hundreds of DNA strands complementary to an RNA covering a glass slide enables the sphere to move, with the help of an enzyme that digests RNA bound to complementary DNA, a thousand times faster than conventional DNA-walkers.

Novel nanoconjugate delivers synergistic combination of microRNAs to treat cancer

Posted by Jim Lewis on December 11th, 2015

Two microRNAs with synergistic effects, one that suppresses tumor growth and another than inhibits tumor promotion, are combined in an RNA triple helix, complexed with a dendrimer to form nanoparticles, which are incorporated with a polymer to form a hydrogel that inhibits tumor growth when applied to the tumor.

Ultrasensitive microRNA assay with nanosensor to detect cancer

Posted by Jim Lewis on December 10th, 2015

A nanotechnology-based sensor provides fast, inexpensive, ultrasensitive assay of microRNA pattern to detect cancer using DNA immobilized on a synthetic gold nanoprism.

DNA nanomachine lights up to diagnose diseases

Posted by Jim Lewis on November 2nd, 2015

DNA nanotechnology produces an artificial molecular machine that changes shape when it encounters a specific antibody or other protein molecule, and emits light to signal the target’s presence.

Foresight co-founder on the future of the human lifespan

Posted by Jim Lewis on October 6th, 2015

Optimized Geek podcast featured Christine Peterson on the future of nanotechnology, human lifespan, artificial intelligence, finding love, and other topics.

Nanotechnology carries gene editing package into cells

Posted by Jim Lewis on October 2nd, 2015

Hijacking a viral method of replicating circular genomes, ball-of-yarn-like DNA clews are used to transport the protein and guide RNA molecules needed for gene editing into the cell nucleus.

DNA nanotechnology guides assembling cells into 'Organoids'

Posted by Jim Lewis on September 30th, 2015

DNA strands decorating cell membranes like ‘Velcro’ program the adhesion of cells to other cells or to extracellular matrices to build tiny tissue models.

Nanotechnology provides sensors for liver-on-chip drug testing

Posted by Jim Lewis on September 2nd, 2015

Adding nanotechnology-based optoelectronic sensors to human cells cultured on a chip keeps the cells healthy long enough to replace animal testing with a human liver-on-a-chip.

Novel wireframe nanostructures from new DNA origami design process

Posted by Jim Lewis on August 18th, 2015

A new set of design rules enables constructing any wireframe nanostructure, which may lead to new medical applications and new nanomachines.

Foresight co-sponsors Berkeley Bench to Market event

Posted by Jim Lewis on July 30th, 2015

To educate potential entrepreneurs on strategies for moving discoveries from the benchtop to successful commercialization, Foresight co-sponsored an event in the “Ph.D. to Startup” Workshop Series of the Berkeley Postdoc Entrepreneur Program.

Foresight 1999 Distinguished Student wins Galactic Grant Competition

Posted by Jim Lewis on July 28th, 2015

Technology developed by Nanobiosym, founded by Anita Goel, to enable personalized diagnostic testing won the Grand Prize of the Nokia Sensing XCHALLENGE in 2013, and this month was awarded the top prize in the Galactic Grant Competition.

Linking together small DNAs to build more diverse DNA nanostructures

Posted by Jim Lewis on July 2nd, 2015

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

DNA nanomachines more stable than expected in human serum and blood

Posted by Jim Lewis on June 29th, 2015

Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.

Google Tech Talk video by Feynman Prize Winner

Posted by Jim Lewis on June 24th, 2015

Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.

Conference video: Regenesis: Bionano

Posted by Jim Lewis on June 9th, 2015

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.