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Archive for the 'Nanomedicine' Category

Novel wireframe nanostructures from new DNA origami design process

Posted by Jim Lewis on August 18th, 2015

A new set of design rules enables constructing any wireframe nanostructure, which may lead to new medical applications and new nanomachines.

Foresight co-sponsors Berkeley Bench to Market event

Posted by Jim Lewis on July 30th, 2015

To educate potential entrepreneurs on strategies for moving discoveries from the benchtop to successful commercialization, Foresight co-sponsored an event in the “Ph.D. to Startup” Workshop Series of the Berkeley Postdoc Entrepreneur Program.

Foresight 1999 Distinguished Student wins Galactic Grant Competition

Posted by Jim Lewis on July 28th, 2015

Technology developed by Nanobiosym, founded by Anita Goel, to enable personalized diagnostic testing won the Grand Prize of the Nokia Sensing XCHALLENGE in 2013, and this month was awarded the top prize in the Galactic Grant Competition.

Linking together small DNAs to build more diverse DNA nanostructures

Posted by Jim Lewis on July 2nd, 2015

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

DNA nanomachines more stable than expected in human serum and blood

Posted by Jim Lewis on June 29th, 2015

Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.

Google Tech Talk video by Feynman Prize Winner

Posted by Jim Lewis on June 24th, 2015

Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.

Conference video: Regenesis: Bionano

Posted by Jim Lewis on June 9th, 2015

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Nanoparticles shepherd DNA into cells to regulate immune response

Posted by Jim Lewis on May 6th, 2015

DNA sequences designed to either stimulate a specific immune response or to down-regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.

Gold nanotubes engineered for diagnosis and therapy

Posted by Jim Lewis on April 30th, 2015

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

Solid-phase synthesis of custom-made DNA nanotubes

Posted by Jim Lewis on April 9th, 2015

Single-molecule spectroscopy makes possible adding one rung at a time to a foundational rung grafted to a surface to make a long nanotube scaffold of predetermined sequence.

DNA nanoswitches open window on molecular interactions

Posted by Jim Lewis on April 5th, 2015

Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.

New scaffold for nanotechnology engineered from amyloid-like proteins

Posted by Jim Lewis on April 4th, 2015

Design and computational simulation of amyloid proteins of diverse functions from diverse sources enable the self-assembly of proteins that could provide scaffolds for diverse applications.

Automated synthesis expands nanotechnology building block repertoire

Posted by Jim Lewis on March 24th, 2015

Iterative coupling, purification, and cyclization of a large collection of organic building blocks promises a vast array of complex small and medium sized molecules as candidates for drug discovery, catalysis, and nanotechnology.

Targeted nanoparticles deliver molecules to resolve atherosclerotic inflammation

Posted by Jim Lewis on March 9th, 2015

In tests in a mouse model of advanced atherosclerosis, core-shell nanoparticles, composed of block copolymers and targeted to sites of inflammation and vascular injury, delivered a bioactive peptide that improved key properties of advanced plaques.

Mixing two types of nanoparticle triggers structure change

Posted by Jim Lewis on February 5th, 2015

Mixing two different types of cylindrical nanoparticles causes them to reorganize into smaller spherical nanoparticles. A mechanism to release drugs only inside cells that internalize both types?

Simple nanotechnology modification of alumina surface discourages bacteria

Posted by Jim Lewis on February 2nd, 2015

A simple method of producing nanoporous alumina surface discourages bacteria from attaching and forming biofilms, with potential applications in medicine, dentistry, and food processing.

Structural DNA nanotechnology with programmed motions

Posted by Jim Lewis on January 28th, 2015

Scaffolded DNA origami is combined with hinges of single- or double-stranded DNA to built simple machines parts that have been combined to program simple to complex motions.

Swarms of DNA nanorobots execute complex tasks in living animal

Posted by Jim Lewis on January 6th, 2015

Combinations of different types of DNA nanorobots, implementing different logic gates, work together to tag a specific type of cell in a living cockroach depending on the presence or absence of two protein signals.

New software reveals more molecular machine structures

Posted by Jim Lewis on December 31st, 2014

New software makes it possible to generate 3D structures of proteins without artificially incorporating metal atoms in the proteins, making it possible to study many molecular machines using data that could not previously be analyzed.

Computational framework for structural DNA nanotechnology

Posted by Jim Lewis on December 27th, 2014

A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?