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Archive for the 'Nanomedicine' Category

Solid-phase synthesis of custom-made DNA nanotubes

Posted by Jim Lewis on April 9th, 2015

Single-molecule spectroscopy makes possible adding one rung at a time to a foundational rung grafted to a surface to make a long nanotube scaffold of predetermined sequence.

DNA nanoswitches open window on molecular interactions

Posted by Jim Lewis on April 5th, 2015

Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.

New scaffold for nanotechnology engineered from amyloid-like proteins

Posted by Jim Lewis on April 4th, 2015

Design and computational simulation of amyloid proteins of diverse functions from diverse sources enable the self-assembly of proteins that could provide scaffolds for diverse applications.

Automated synthesis expands nanotechnology building block repertoire

Posted by Jim Lewis on March 24th, 2015

Iterative coupling, purification, and cyclization of a large collection of organic building blocks promises a vast array of complex small and medium sized molecules as candidates for drug discovery, catalysis, and nanotechnology.

Targeted nanoparticles deliver molecules to resolve atherosclerotic inflammation

Posted by Jim Lewis on March 9th, 2015

In tests in a mouse model of advanced atherosclerosis, core-shell nanoparticles, composed of block copolymers and targeted to sites of inflammation and vascular injury, delivered a bioactive peptide that improved key properties of advanced plaques.

Mixing two types of nanoparticle triggers structure change

Posted by Jim Lewis on February 5th, 2015

Mixing two different types of cylindrical nanoparticles causes them to reorganize into smaller spherical nanoparticles. A mechanism to release drugs only inside cells that internalize both types?

Simple nanotechnology modification of alumina surface discourages bacteria

Posted by Jim Lewis on February 2nd, 2015

A simple method of producing nanoporous alumina surface discourages bacteria from attaching and forming biofilms, with potential applications in medicine, dentistry, and food processing.

Structural DNA nanotechnology with programmed motions

Posted by Jim Lewis on January 28th, 2015

Scaffolded DNA origami is combined with hinges of single- or double-stranded DNA to built simple machines parts that have been combined to program simple to complex motions.

Swarms of DNA nanorobots execute complex tasks in living animal

Posted by Jim Lewis on January 6th, 2015

Combinations of different types of DNA nanorobots, implementing different logic gates, work together to tag a specific type of cell in a living cockroach depending on the presence or absence of two protein signals.

New software reveals more molecular machine structures

Posted by Jim Lewis on December 31st, 2014

New software makes it possible to generate 3D structures of proteins without artificially incorporating metal atoms in the proteins, making it possible to study many molecular machines using data that could not previously be analyzed.

Computational framework for structural DNA nanotechnology

Posted by Jim Lewis on December 27th, 2014

A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?

Artificial enzymes created from building blocks not found in nature

Posted by Jim Lewis on December 22nd, 2014

Artificial enzymes have been created from nucleic acids that use synthetic molecules instead of ribose or deoxyribose sugars.

Large, open protein cages designed and built

Posted by Jim Lewis on December 7th, 2014

Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.

Novel multifunctional nanoparticle for diagnosis and therapy

Posted by Jim Lewis on September 14th, 2014

A nanoparticle that self-assembles from porphyrin, cholic acid, amino acids, and polyethylene glycol is a promising vehicle for delivering both imaging agents and cancer drugs to tumors.

What kind of nanomachines will advanced nanotechnology use?

Posted by Jim Lewis on August 31st, 2014

An interview with UK nanotechnologist Richard Jones argues that the surest and most efficient path to advanced nanomachine function will incorporate or mimic biomolecular nanomachinery rather than scaled down rigid conventional machinery.

Discount to attend SENS Rejuvenation Biotechnology Conference

Posted by Jim Lewis on July 11th, 2014

Foresight friends can use this discount to attend the SENS Rejuvenation Biotechnology Conference August 21-23, 2014 Santa Clara, California.

Lipid coat protects DNA nanorobot from immune attack

Posted by Jim Lewis on July 5th, 2014

Enveloped DNA nanostructures were developed to escape attacks from nucleases and the immune system, opening a path to ever more sophisticated DNA nanomedical devices.

Photos from 2014 Foresight Technical Conference

Posted by Jim Lewis on June 24th, 2014

The photos from the 2014 Foresight Technical Conference highlight entrepreneurial efforts in space, biotechnology, and life extension.

Robust triangular RNA brick adds to RNA nanotechnology toolkit

Posted by Jim Lewis on June 24th, 2014

The complex molecular recognition code of RNA offers RNA nanotechnology a greater variety of 3D structures and functions than are present in DNA nanotechnology, but the RNA structures can be fragile. New RNA triangles that resist boiling solve this problem.

To fight inflammation nanoparticles turn 'naughty' neutrophils into 'nice' neutrophils

Posted by Jim Lewis on May 1st, 2014

By targeting the protein that attaches a type of immune cell called neutrophils to blood vessel walls where they cause serious tissues damage, the neutrophils are released and returned to the circulation to resume their normal functions.