Gold nanoparticles densely coated with RNA molecules intended to silence a gene essential for an incurable brain cancer proved effective in mice engrafted with human glioblastoma multiforme tumor.
Archive for the 'Nanomedicine' Category
Modifying DNA strands with lipid-like molecules opens more possibilities for designing DNA structures for drug delivery and other purposes.
“Molecular threading”, a nanotechnology developed by Halcyon Molecular and now owned by Aeon Biowares, enables precise placement of individual long molecules of DNA, either for sequencing or for nanofabrication of novel DNA nanostructures.
Doug Wolens’s documentary “THE SINGULARITY: Will we survive our technology” premieres at San Francisco’s Castro Theatre September 16, 2013.
The Conference to be held February 7-9, 2014 in Palo Alto, California will emphasize the integration of nano-engineered devices and materials into larger, more complex systems.
In simplest terms, cellular automata can be thought of as groups of ‘cells’ in which the state of an individual cell will flip depending on the states of its neighbors. A ‘cell’ can be a pixel, a molecule, etc. The mathematical rules associated with cellular automation are complex and have been applied to fields as [...]
Good old fashioned boxes are here to stay, even in the context of nanoscale devices. Across a broad range of technologies and size regimes, boxes serve as containers for components, barriers against contaminants and/or radiation, and, as in the case of cell membranes, can be permeable to allow selected interactions between the interior and exterior. [...]
Recently we pointed at a Forbe’s interview with Eric Drexler, in anticipation of his pending new book Radical Abundance. The book has shipped, and Drexler’s tour schedule now includes a few stops on the coasts of the U.S: New York: May 6th Los Angeles: May 8th & 9th Seattle: May 9th Find exact times and [...]
Revolution of DNA around a central channel, rather than rotation, is the method used by a viral molecular motor to package DNA. A structure facilitating bottom-up assembly may lead to roles in nanotechnology for these nanomotors.
In anticipation of Eric Drexler’s new book, Forbes contributor Bruce Dorminey interviews him about the meaning of nanotechnology and its revolutionary prospects. Selected excerpt: … In what fields would APM cause the most pronounced economic disruption and the collapse of global supply chains to more local chains? The digital revolution had far-reaching effects on information [...]
Nanoparticles decorated to avoid immune system recognition were tested in mice and shown to survive longer and deliver more imaging dye and drug to tumor cells.
In this Forbes interview, contributor John Nosta introduces us to a teen worth watching: fifteen-year-old Jack Andraka, whose effort to design a nanotube-based sensor for pancreatic cancer detection was initially ignored. The interview taps into some aspects of how innovation occurs and the challenges of bringing new ideas to fruition – aspects which transcend age, [...]
Core-shell nanocapsules deliver a potent protein complex to the nucleus of cancer cells where it induces them to commit suicide, while the complex degrades harmlessly in the cytoplasm of normal cells.
In a 47-minute interview Christine Peterson discusses the future that science and technology is bringing over the next few decades, and how to get involved to push the future in a positive direction.
An interview with Foresight Co-Founder and Past President Christine Peterson covering both the current state and the future prospects of nanotechnology is available on Youtube.
A demonstration that most fundamental biological processes can be implemented in a test tube as efficiently as in live bacteria provides synthetic biology the tools to create a ‘new industrial revolution’, which may or may not lead to more general molecular manufacturing.
Researchers from Johns Hopkins and Northwestern Universities developed a set of shape-tunable DNA-copolymer nanoparticles that incorporate a fixed amount of DNA yet display as much as 1,680-fold difference in transfection efficiency in rat liver studies. The study may shed new light on the importance of shape in nanoparticle-based drug delivery and gene therapy.
Optimizing the size and charge of nanoparticles engineered from polymers delivers drugs directly to mitochondria, effectively treating cells with drugs for a variety of diseases.
A combination of theoretical and experimental work on peptoids, synthetic analogs of proteins, points to the ability to design peptoids with desired structures and functions.
Studies in mice with otherwise fatal blood clots have shown that targeting a clot-busting drug to regions where blood flow is blocked restores circulation and increases survival with a much lower, safer dose of the drug.