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Archive for the 'Nanomedicine' Category

Christine Peterson on pushing the future in a positive direction

Posted by Jim Lewis on February 20th, 2013

In a 47-minute interview Christine Peterson discusses the future that science and technology is bringing over the next few decades, and how to get involved to push the future in a positive direction.

Christine Peterson interviewed on nanotechnology

Posted by Jim Lewis on February 12th, 2013

An interview with Foresight Co-Founder and Past President Christine Peterson covering both the current state and the future prospects of nanotechnology is available on Youtube.

Synthetic biology industrial revolution inspires hope for molecular manufacturing

Posted by Jim Lewis on February 2nd, 2013

A demonstration that most fundamental biological processes can be implemented in a test tube as efficiently as in live bacteria provides synthetic biology the tools to create a ‘new industrial revolution’, which may or may not lead to more general molecular manufacturing.

Shape may play an important role in nanoparticle-based therapeutics

Posted by Stephanie C on October 19th, 2012

Researchers from Johns Hopkins and Northwestern Universities developed a set of shape-tunable DNA-copolymer nanoparticles that incorporate a fixed amount of DNA yet display as much as 1,680-fold difference in transfection efficiency in rat liver studies. The study may shed new light on the importance of shape in nanoparticle-based drug delivery and gene therapy.

Nanoparticles deliver cargo inside mitochondria

Posted by Jim Lewis on October 9th, 2012

Optimizing the size and charge of nanoparticles engineered from polymers delivers drugs directly to mitochondria, effectively treating cells with drugs for a variety of diseases.

Rational design of peptoids: a route to advanced nanotechnology?

Posted by Jim Lewis on September 7th, 2012

A combination of theoretical and experimental work on peptoids, synthetic analogs of proteins, points to the ability to design peptoids with desired structures and functions.

Shear-activated nanoparticles may target blood clots

Posted by Jim Lewis on August 16th, 2012

Studies in mice with otherwise fatal blood clots have shown that targeting a clot-busting drug to regions where blood flow is blocked restores circulation and increases survival with a much lower, safer dose of the drug.

Nanozyme destroys virus in human cells and in mice

Posted by Jim Lewis on July 30th, 2012

Nanotechnology combines an enzyme and a DNA molecule on the surface of gold nanoparticles to destroy hepatitis C virus in human cells and in a mouse model of disease.

Atomically precise nanoparticle provides better drug delivery

Posted by Jim Lewis on July 10th, 2012

Nanoparticles made from specific DNA and RNA strands, homogeneous in size, composition, and surface chemistry, proved superior to other nanoparticles in silencing gene expression in tumors in mouse experiments.

Nanotechnology greatly improves sensitivity of common medical tests

Posted by Jim Lewis on June 21st, 2012

A new nanomaterial provides a three million-fold improvement in the sensitivity of common medical tests, potentially permitting earlier detection of cancer and Alzheimer’s disease.

Advancing nanotechnology with protein building blocks

Posted by Jim Lewis on June 6th, 2012

A variety of protein cage structures have been constructed by designing specific protein domains to self-assemble as atomically precise protein building blocks in defined geometries.

DNA tiles provide faster, less expensive way to fabricate complex DNA objects

Posted by Jim Lewis on May 31st, 2012

A set of 310 short single-stranded DNA tiles, plus a few additional short sequences for the edges, has been used to form more than a hundred large, complex DNA objects.

Foresight Presents: “GENOGEN: Regenerating Skin for Life”, with Dr. Nancy Mize

Posted by Jim Lewis on May 20th, 2012

Nancy K Mize, PhD, Scientist, Innovator, and CEO of GENOGEN Inc., will continue Foresight’s local Bay Area community events with a lecture “GENOGEN: Regenerating Skin for Life”. GENOGEN is developing products that activate resident skin stem cells to stimulate local areas of regeneration of skin naturally – the way children heal.

Drug-resistant cancer cells cannot resist plasmonic nanobubbles

Posted by Jim Lewis on May 13th, 2012

Nanoparticles targeted to cancer cells by antibodies cannot achieve enough specificity to kill drug-resistant cancer cells while sparing normal cells, but can achieve enough specificity to produce nanobubbles only in cancer cells, so the drug only enters cancer cells.

Gold nanostars shuttled to cancer cell nucleus to release drug

Posted by Jim Lewis on April 24th, 2012

Gold nanostars targeted to a protein over-expressed in most cancer cells are shuttled by that protein directly to the cancer cell nucleus where illumination with a laser light releases a drug that deforms the nucleus and kills the cell.

Nanoparticles reduce tumors in clinical trial

Posted by Jim Lewis on April 17th, 2012

Clinical trials in patients with advanced or metastatic tumors using targeted nanoparticles to deliver a standard chemotherapeutic drug showed tumor shrinkage, even in the case of cancers for which that drug is not normally effective.

Nanotechnology-based sensor does rapid reads of single DNA molecule

Posted by Jim Lewis on April 1st, 2012

A combination of a molecular motor protein and a nanopore protein has been harnessed for rapidly sequencing single DNA molecules.

Nanotechnology regrows blood vessels after ischemic damage

Posted by Jim Lewis on March 26th, 2012

In a rat model of ischemic damage, nanoparticle delivery of a growth factor and a coreceptor promotes regrowth of damaged blood vessels in seven days.

Faster, less expensive medical diagnostics through nanotechnology

Posted by Jim Lewis on March 23rd, 2012

New protein repellent coating enhances the speed of carbon nanotube-based biosensors, pointing the way to faster, cheaper medical diagnostics.

DNA nanotechnology-based nanorobot delivers cell suicide message to cancer cells

Posted by Jim Lewis on March 8th, 2012

Functioning DNA nanorobots to deliver specific molecular signals to cells were designed by combining DNA origami, DNA aptamers, and DNA logic gates.