Optimizing the size and charge of nanoparticles engineered from polymers delivers drugs directly to mitochondria, effectively treating cells with drugs for a variety of diseases.
Archive for the 'Nanomedicine' Category
A combination of theoretical and experimental work on peptoids, synthetic analogs of proteins, points to the ability to design peptoids with desired structures and functions.
Studies in mice with otherwise fatal blood clots have shown that targeting a clot-busting drug to regions where blood flow is blocked restores circulation and increases survival with a much lower, safer dose of the drug.
Nanotechnology combines an enzyme and a DNA molecule on the surface of gold nanoparticles to destroy hepatitis C virus in human cells and in a mouse model of disease.
Nanoparticles made from specific DNA and RNA strands, homogeneous in size, composition, and surface chemistry, proved superior to other nanoparticles in silencing gene expression in tumors in mouse experiments.
A new nanomaterial provides a three million-fold improvement in the sensitivity of common medical tests, potentially permitting earlier detection of cancer and Alzheimer’s disease.
A variety of protein cage structures have been constructed by designing specific protein domains to self-assemble as atomically precise protein building blocks in defined geometries.
A set of 310 short single-stranded DNA tiles, plus a few additional short sequences for the edges, has been used to form more than a hundred large, complex DNA objects.
Nancy K Mize, PhD, Scientist, Innovator, and CEO of GENOGEN Inc., will continue Foresight’s local Bay Area community events with a lecture “GENOGEN: Regenerating Skin for Life”. GENOGEN is developing products that activate resident skin stem cells to stimulate local areas of regeneration of skin naturally – the way children heal.
Nanoparticles targeted to cancer cells by antibodies cannot achieve enough specificity to kill drug-resistant cancer cells while sparing normal cells, but can achieve enough specificity to produce nanobubbles only in cancer cells, so the drug only enters cancer cells.
Gold nanostars targeted to a protein over-expressed in most cancer cells are shuttled by that protein directly to the cancer cell nucleus where illumination with a laser light releases a drug that deforms the nucleus and kills the cell.
Clinical trials in patients with advanced or metastatic tumors using targeted nanoparticles to deliver a standard chemotherapeutic drug showed tumor shrinkage, even in the case of cancers for which that drug is not normally effective.
A combination of a molecular motor protein and a nanopore protein has been harnessed for rapidly sequencing single DNA molecules.
In a rat model of ischemic damage, nanoparticle delivery of a growth factor and a coreceptor promotes regrowth of damaged blood vessels in seven days.
New protein repellent coating enhances the speed of carbon nanotube-based biosensors, pointing the way to faster, cheaper medical diagnostics.
Functioning DNA nanorobots to deliver specific molecular signals to cells were designed by combining DNA origami, DNA aptamers, and DNA logic gates.
A talk at TEDxBerkeley includes nanotechnology among the options for digital fabrication, one of five new rules of innovation.
Artist’s conception of a nanopore drilled into a layer of graphene to speed up DNA sequencing. One of the greatest promises of near-term nanotechnoloogy is cheaper DNA sequencing to speed the development of personalized medicine. There are not only genetic differences between different patients, but also genetic differences between, for example, different cancers of the [...]
Human life after advanced nanotechnology has been developed will be fundamentally different from life up until that point.
The first Master’s of Science in Nanomedicine degree program in US is announced. As an example of the rapidly developing potential of nanomedicine, a novel type of nanoparticle succeeded in two different mouse models in destroying a type of brain cancer that had previously been completely resistant to all treatment attempts.