A new polymer that disintegrates in response to harmless radiation that can penetrate several inches into human tissue may lead to nanoparticles that release their drug cargo only at a desired time and place.
Archive for the 'Nanomedicine' Category
To counter the threat of evolved or engineered resistance of pathogenic bacteria to antibiotics, Darpa proposes to use nanotechnology to develop “Rapidly Adaptable Nanotherapeutics”.
Small DNA molecules fluoresce in the presence of specific transcription factors, sensing which genes are being expressed in that cell, potentially allowing cancer treatments to be personalized, and the quality of stem cells to be monitored.
This contribution has been forwarded by Ivo Rivetta. The primary forces on the nanometer scale are scaled versions of what we experience on a day to day basis. Instead of gravity, surface forces such as water tension and electric charge dominate. As an example, compare wet basketballs and wet sand. The weight of the basketballs [...]
Yarn woven from carbon nanotubes provides a thousand times more rotation than is obtained from other artificial muscles, and could be made into motors to provide propulsion for micrometer-sized medical nanorobots.
This contribution has been forwarded by Ivo Rivetta. Researchers at UC Berkeley have taken a bioinspired approach to control the nanostructure of deposited thin films. In living organisms, the orientation of collagen in tissue determines its properties: For instance, a number of blue-skinned animals, including the mandrill monkey, derive their coloring not from pigment, but [...]
A complex piece of DNA that acts as a biological computer when it is inserted into cells determines whether or not the cell is a specific type of cancer cell, and if so, initiates the suicide of that cell.
Nanotechnology has been applied to produce various types of nanoparticles that can deliver toxic agents specifically to the cancer cells. Many of these approaches have shown promise in animal studies. One approach using magnetic nanoparticles has now gone into trials in patients. From “Nano-therapy that cooks deadly brain tumors advances in Germany,” by Ryan McBride: [...]
Growing heart cells in a scaffold containing gold nanowires produces a tissue patch that is thicker and in which the cells beat synchronously as they do in healthy heart tissue.
A neural network made from 112 DNA strands organized into four artificial neurons was trained with four pieces of information to answer questions.
DNA nanotechnology provides cell-surface sensors for real-time monitoring of single cells, including potential use in personalized medicine to test which drugs would be suitable for which individuals.
A nanotechnology therapy using targeted dendrimers shows promise against head and neck cancer in experiments in which human tumors are implanted into immunocompromised mice.
The world’s first synthetic organ transplant was a replica windpipe made from a nanocomposite scaffold seeded with the patient’s own adult stem cells.
Treatment of mice previously infected with a lethal dose of flu virus with a nanotechnology-based drug lowered viral load a thousand fold.
A biochemical circuit built from 74 small DNA molecules demonstrates an approach that may enable embedded control of molecular devices.
Carbon nanofibers and a polymer were combined to create a composite to regenerate natural heart tissue.
A poll of NewScientist readers selected medical nanorobots as the technology that will have the biggest impact on human life in the next 30 years.
Protein, RNA, DNA provide very different molecular architectures for nanotechnology to adopt to deliver drugs to cancer cells while sparing healthy cells.
‘Good Cholesterol’ nanoparticles are non-toxic and use the need of cancer cells for HDL cholesterol to deliver RNA molecules to silence the expression of cancer-promoting genes.
Porous silica nanoparticles covered with a lipid bilayer deliver large doses of drugs and kill cancer cells a million fold better than do simple liposomes.