An overview of three decades of progress in DNA nanotechnology emphasizes bringing programmed motion to DNA nanostructures, including efforts to incorporate design principles from macroscopic mechanical engineering.
Archive for the 'Atomically Precise Manufacturing (APM)' Category
Scaffolded DNA origami is combined with hinges of single- or double-stranded DNA to built simple machines parts that have been combined to program simple to complex motions.
One example is presented of how well the meme is spreading that nanotechnology will evolve toward atomically precise manufacturing that will in turn bring forth a world of abundance.
Combinations of different types of DNA nanorobots, implementing different logic gates, work together to tag a specific type of cell in a living cockroach depending on the presence or absence of two protein signals.
New software makes it possible to generate 3D structures of proteins without artificially incorporating metal atoms in the proteins, making it possible to study many molecular machines using data that could not previously be analyzed.
A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?
A new strategy to form bonds between carbon atoms opens the way to a wide variety of molecular architectures that had been difficult or impossible to access using previous methods.
Advances in the de novo design of coiled-coil proteins made by two different research groups proceeding by two different routes demonstrate that the range of protein nanostructures potentially available for various molecular machine systems is significantly larger than the range of such structures already exploited by natural selection.
A general framework is presented for using 32-nucleotide DNA bricks to build large two-dimensional crystals up to 80 nm thick and incorporating sophisticated three-dimensional features.
Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.
The US National Science Foundation announced a new grant program to develop and apply next-generation networking to advance nanotechnology and other emerging technologies to meet important national needs.
A small, interactive group of invited experts gathered in Palo Alto recently to discuss prospects for revolutionary advances in energy storage, transmission, and generation through nanotechnology.
The need for improved imaging and characterization on the nanoscale was emphasized in the 2007 Roadmap and again at the 2013 Foresight Conference on Atomic Precision. We noted last year a new advancement in atomic-scale resolution of 10-nm platinum particles, requiring multiple imaging techniques in combination, and recently the marked improvement in optical imaging for [...]
To emulate the process by which nature assembles complex organic molecules by passing subunits through a series of enzyme domains, UK chemists developed a procedure to elongate a boronic ester by using a reagent that inserts into carbon-boron bonds with precise control of molecular configuration.
The US NSF has announced a program to support fundamental research leading to complex nanosystems.
A new DARPA program seeks to bridge the gap from atoms to macroscale product manufacture in two steps, the first of which is from atoms to micrometer-scale feedstocks. DNA origami may be part of the solution.
A 10-fold larger breadboard and 350-fold lower DNA synthesis costs make DNA origami a more useful stepping-stone toward atomically precise manufacturing.
Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.
Register by Sept. 5 to attend a Proposers Day webinar on either Sept. 9 or 11 to learn the technical objectives of DARPA’s new “Atoms to product: Aiming to make nanoscale benefits life-sized” program.
An interview with UK nanotechnologist Richard Jones argues that the surest and most efficient path to advanced nanomachine function will incorporate or mimic biomolecular nanomachinery rather than scaled down rigid conventional machinery.