Computational design of proteins satisfying predetermined geometric constraints produced stable proteins with the designed structure that are not found in nature.
Archive for the 'Atomically Precise Manufacturing (APM)' Category
A fully automated design protocol generates dozens of designs for proteins based on helix-loop-helix-loop repeat units that are very stable, have crystal structures that match the design, have very different overall shapes, and are unrelated to any natural protein.
DNA building blocks mimic biological ion channels to more precisely control which molecules can cross a biological membrane.
A molecular robotic arm synthesized from small synthetic organic molecules uses cyclic changes in pH and other reaction conditions to grab and release a cargo molecule, and swing the cargo back and forth between the two ends of the molecular platform.
German researchers have used scaffolded DNA origami to adjust the angle of a DNA hinge joint by altering the length of special “adjuster helices”, causing molecules attached to the sides of the hinge to be displaced by as little as 0.04 nm.
Nanometer-level control of the beam path of a scanning transmission electron microscope nudges an amorphous material into atomically precise epitaxial growth.
Building on previous work on single atom transistors and single atom qubits, Australian researchers have incorporated a quantum error correction code to make possible a scalable 3D silicon chip architecture that could lead to operational quantum computers.
Independent rotation of two wheels attached to either end of an axle has been achieved in a light-driven artificial molecular motor, suggesting a basis for a nanometer-scale transport system.
A novel application of supramolecular chemistry allows molecules to join in only one direction, providing a new way to control the shape of large molecules.
A lipid bilayer supported by a mica surface assisted the mobile self-assembly of DNA nanostructures of various shapes into micrometer-scale 2D lattices.
A free to read online edition of the classic 3-volume physics text developed from Richard Feynman’s legendary Cal Tech physics lectures, specially designed for online reading, has been made available by the California Institute of Technology and the Feynman Lectures Website.
Optimized Geek podcast featured Christine Peterson on the future of nanotechnology, human lifespan, artificial intelligence, finding love, and other topics.
The ability to dope graphene nanoribbons with boron atoms to atomic precision opens a range of possible new applications, from chemical sensing to nanoelectronics to photocatalysis to battery electrodes.
Simple molecular switches based upon bistable mechanically interlocked molecules can be incorporated within pre-assembled metal organic frameworks and addressed electrochemically.
Modeling DNA strand displacement cascades according to three simple rules can in principle mimic the temporal dynamics of any other chemical system, presenting a method to model regulatory networks even more complicated than those of biology.
An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.
Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.
Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.
At the 2013 Conference Joseph Puglisi described how single molecule fluorescence techniques were used to study changes in the conformation and composition of the ribosome, a large biomolecular nanomachine, during the process of translation of genetic information.
By precise control of several factors, uniform high-performance monolayers of the semiconductor MoS2 have been obtained and used to fabricate field-effect transistors.