A new online game allows players to design RNA molecules. The most promising designs are synthesized, and the players given real-world feedback on how well their designs worked.
Archive for the 'Atomically Precise Manufacturing (APM)' Category
The demonstration that the process of DNA replication is more flexible than thought should make it easier to incorporate unusual amino acids into designed proteins, which might make it easier to design novel protein machines.
A variety of protein cage structures have been constructed by designing specific protein domains to self-assemble as atomically precise protein building blocks in defined geometries.
A set of 310 short single-stranded DNA tiles, plus a few additional short sequences for the edges, has been used to form more than a hundred large, complex DNA objects.
Darpa has launched a “Living Foundries” program to bring an engineering perspective to synthetic biology to greatly accelerate progress through standardization and modularization.
Recent interview touches on new Foresight programs and issues in nanotechnology development
A set of rationally engineered transcriptional regulators for yeast will make it easier to build complex molecular machine systems in yeast, some of which may become useful additions to pathway technologies for atomically precise manufacturing and productive nanosystems.
Functioning DNA nanorobots to deliver specific molecular signals to cells were designed by combining DNA origami, DNA aptamers, and DNA logic gates.
A talk at TEDxBerkeley includes nanotechnology among the options for digital fabrication, one of five new rules of innovation.
New computational methods to explore the rapidly expanding collection of high resolution three-dimensional RNA structures reveal new RNA structural motifs, identifying additional building blocks for complex RNA nanostructures.
Researchers in Australia and the US have demonstrated a working transistor by placing of single atom of phosphorous with atomic precision between gates made of wires only a few phosphorous atoms wide. This demonstration points to possibly extending current computer technology to the atomic scale.
Scientists at Kyoto University and the University of Oxford have combined DNA origami and DNA motors to take another step toward programmed artificial molecular assembly lines.
Foldit game players have again out-performed scientists in protein design, this time improving the design of a protein designed from scratch to catalyze Diels-Alder cycloadditions.
An array of 96 iron atoms on a copper nitride surface, assembled using an STM and used to write a byte, demonstrates how small magnetic storage could shrink and may lead to novel nanomaterials for quantum computers.
An article in The Guardian quotes Christine Peterson and Robert Freitas on the vision of molecular manufacturing. Freitas is quoted as expecting that the development of nanofactories could be done in 20 years for “on the order of” one billion dollars.
A four-step unidirectional molecular motor driven by light and temperature changes catalyzes different chemical reactions at different steps of its rotary cycle.
A tutorial review available after free registration presents a theory-based exploration of the difficulty in moving from simple molecular switches to arrays of artificial molecular machines capable to doing substantial, useful external work.
RNA CAD tools developed for RNA-regulated control of gene expression in synthetic biology successfully engineered metabolic pathways in bacteria. Will engineering RNA-based genetic control systems lead to design tools for other RNA-based molecular machine systems?
Protein-like structures called peptoids can be formed into stable, free-floating nanosheets.
When can we expect advanced nanomachinery to be commercialized? Will any technologies not be affected in some way by advanced nanotechnology?