thielfellowship.org

http://www.nytimes.com/2012/09/16/business/the-thiel-fellows-forgoing-college-to-pursue-dreams.html

http://www.hulu.com/20-under-20-transforming-tomorrow

National Chemistry Week 2012: Nanotechnology, Oct. 21-27th
The focus of the 25th National Chemistry Week is “Nanotechnology – The Smallest BIG Idea In Science.” Use the link to find events scheduled for your area, connect with NCW coordinators and other like-minded thinkers, and/or learn how to set up your own event.

NanoDays 2013: March 30 – April 7th
Organized by participants in the Nanoscale Informal Science Education Network, NanoDays is

a nationwide festival of educational programs about nanoscale science and engineering and its potential impact on the future.

Events are held at science museums, observatories, universities, and more. Kits are available to applicants, providing experiments and tips for anyone interested in hosting an event, or find out about designing your own.

Science Coaches Program: Apply By October 30th
This remarkable program gives you the opportunity to team-up with a like-minded middle- or high school teacher in your community to bring nanotechology-oriented concepts and experiences to students. The ACS Science Coaches program is entering its third academic year.

Kids & Chemistry Program
The ACS Kids & Chemistry program is aimed at younger students and offers broad flexibility regarding the size of your volunteer commitment.

Volunteer efforts can be implemented as a full program administered by an ACS local section or by an individual as a one-time classroom visit.

Already participating in any of these programs? Know of other programs worth pointing at? Leave a Comment to let us know.
-Posted by Stephanie C

(Credit: EteRNA)

As we pointed out a few months ago, the greater complexity of folding rules for RNA compared to its chemical cousin DNA gives RNA a greater variety of compact, three-dimensional shapes and a different set of potential functions than is the case with DNA, and this gives RNA nanotechnology a different set of advantages compared to DNA nanotechnology as a road towards atomically precise manufacturing. Proteins have even more complex folding rules and an even greater variety of structures and functions. We also noted here that online gamers playing Foldit topped scientists in redesigning a protein to achieve a novel enzymatic activity that might be especially useful in developing molecular building blocks for molecular manufacturing. Now KurzweilAI.net brings news of an online game that allows players to design RNA molecules “New videogame lets amateur researchers mess with RNA“.

EteRNA, an online game with more than 38,000 registered users, allows players to design molecules of ribonucleic acid — RNA — that have the power to build proteins or regulate genes.

EteRNA players manipulate nucleotides, the fundamental building blocks of RNA, to coax molecules into shapes specified by the game.

Those shapes represent how RNA appears in nature while it goes about its work as one of life’s most essential ingredients.

EteRNA was developed by scientists at Stanford and Carnegie Mellon universities, who use the designs created by players to decipher how real RNA works. The game is a direct descendant of Foldit — another science crowdsourcing tool disguised as entertainment — which gets players to help figure out the folding structures of proteins.

The game’s elite players compete for a unique and wondrous prize: the chance to have RNA designs of their own making brought to life. Every two weeks, four to 16 player-designed molecules are picked to be synthesized in an RNA lab at Stanford.

The chance to win this reward has proven highly motivating for EteRNA‘s players. They carefully study the data that the lab provides on how the synthesized molecules behave when ushered into existence, then use their observations to refine their next designs. In doing so, they — like their Foldit-playing peers — have helped scientists take advantage of the human brain’s unparalleled talent for recognizing patterns and solving puzzles.

But EteRNA players have also done something much more profound: By scrutinizing their creations, learning from their triumphs and mistakes, and using their accumulated wisdom to develop new hypotheses, they aren’t just building better RNA molecules; they’re discovering fundamental aspects of biochemistry that no one — not even the world’s top RNA researchers — knew before. And in doing so, they are blurring the line that separates gamer from scientist …

The article goes on to discuss a growing movement among EteRNA players to synthesize their RNA molecules themselves, linking online scientific game-playing and crowd-sourced molecular design to Open Science and DIY Biotechnology. The EteRNA web site provides tutorials to get new users started and instant feedback. Could games like Foldit and EteRNA represent new crowd-sourced paths to the more rapid development of atomically precise manufacturing?
—James Lewis, PhD

Obsessive gamers’ hours at the computer have now topped scientists’ efforts to improve a model enzyme, in what researchers say is the first crowdsourced redesign of a protein.

The online game Foldit, developed by teams led by Zoran Popovic, director of the Center for Game Science, and biochemist David Baker, both at the University of Washington in Seattle, allows players to fiddle at folding proteins on their home computers in search of the best-scoring (lowest-energy) configurations.

The researchers have previously reported successes by Foldit players in folding proteins, but the latest work moves into the realm of protein design, a more open-ended problem. By posing a series of puzzles to Foldit players and then testing variations on the players’ best designs in the lab, researchers have created an enzyme with more than 18-fold higher activity than the original. The work was published January 22 in Nature Biotechnology [abstract].

“I worked for two years to make these enzymes better and I couldn’t do it,” says Justin Siegel, a post-doctoral researcher working in biophysics in Baker’s group. “Foldit players were able to make a large jump in structural space and I still don’t fully understand how they did it.” …

The latest effort involved an enzyme that catalyses one of a family of workhorse reactions in synthetic chemistry called Diels-Alder reactions. Members of this huge family of reactions are used throughout industry to synthesize everything from drugs to pesticides, but enzymes that catalyze Diels-Alder reactions have been elusive. In 2010, Baker and his team reported that they had designed a functional Diels–Alderase computationally from scratch [abstract], but, says Baker, “it wasn’t such a good enzyme”. The binding pocket for the pair of reactants was too open and activity was low. After their attempts to improve the enzyme plateaued, the team turned to Foldit.

In one puzzle, the researchers asked users to remodel one of four amino-acid loops on the enzyme to increase contact with the reactants. In another puzzle, players were asked for a design that would stabilize the new loop. The researchers got back nearly 70,000 designs for the first puzzle and 110,000 for the second, then synthesized a number of test enzymes based on the best designs, ultimately resulting in the final, 18-fold-more-active enzyme.…

The article was written by Jessica Marshall and reprinted in Scientific American with permission from Nature, where it was originally published as “Victory for crowdsourced biomolecule design: Players of the online game Foldit guide researchers to a better enzyme.” The article does an excellent job of describing how researchers and game players collaborated to achieve the final result. The gamers explored much more radical changes to the protein than can be done by conventional molecular biology techniques such as directed evolution, which typic[a]lly explores only single amino acid substitutions. The researchers then physically constructed and characterized the enzyme designed by the gamers.

The choice as design target of an enzyme to catalyze Diels-Alder reactions is particularly interesting from the standpoint of developing advanced nanotechnology, also referred to as molecular manufacturing. As noted in the 2010 Science paper, this reaction is a “cornerstone” in organic synthesis, and no naturally occurring enzymes are known to catalyze this reaction. As early as 1994 Markus Krummenacker proposed the use of Diels-Alder cycloaddition in a strategy to develop molecular building blocks for molecular manufacturing (“Steps towards molecular manufacturing“).

What roles crowd-sourcing, citizen science, and de novo protein design will play in the development of molecular manufacturing, or productive nanosystems, remains to be seen, but this latest result looks like an important step alog the way.
—James Lewis

Our friends over at the Thiel Foundation asked us to help spread the word about their fellowship program, which offers $100,000 grants to innovators age 19 or younger.

If you know of a very bright, energetic, and visionary young person, please bring this opportunity to his or her attention.

Of course, here at Foresight we hope that your protege will work on nanotechnology, and the Thiel Foundation is very interested in this field, but the fellowships are available in a wide range of areas of endeavor.

Below is their message. Think of this as a potentially large holiday gift to the smartest teenager you know!

Another great holiday gift — to yourself and society at large — is your membership in Foresight Institute. Donate by December 31 and your gift will be matched:
http://www.foresight.org/challenge

Best wishes,

Foresight Institute

from the Thiel Foundation:

We’d like to tell you about the 20 Under 20 Thiel Fellowship, a no-strings-attached grant of $100,000 that lets extraordinary young adults skip college and focus on their work, their research, and their self-education. We are delighted to announce that our friends at the Thiel Foundation are now accepting applications for the 2012 class of Fellows.

The future will not take care of itself. Global prosperity is not inevitable. The world will only get better if visionary people are creative and relentless about solving hard problems.

The 2011 class of Thiel Fellows includes 24 people who are tackling breakthroughs in hardware and robotics, making energy plentiful, making markets more effective, challenging the notion that there is only one way to get an education, and extending the human lifespan. Several of them have already launched companies, secured financing, and won prestigious awards. As they’re demonstrating, you don’t need college to invent the future (you can read about their progress in a recent article in TechCrunch).

If you’re under twenty and love science or technology, we hope you’ll consider joining the 2012 class of fellows. Go to ThielFellowship.org and apply to change the world. There’s no cost to apply, and they’re accepting applications through December 31. Fellows will be appointed this spring and begin two-year fellowships this summer.

If you’re twenty or over, we have a different request. Think of the smartest, most creative person you know who’s 19 or younger. Sit down and talk with that person about her or his goals and interests. For some people, such as future doctors, the time and cost of four years of college may be worth it. But for those who plan to invent things or start companies, starting now may make more sense. If your friend is interested, you might suggest pursuing an innovation or applying to the Thiel Fellowship.

Millions of people enjoy a higher quality of life because smart people like Steve Jobs, Muriel Siebert, Benjamin Franklin, Mark Zuckerberg, and hundreds of others skipped college to start a project that couldn’t wait.

We hope you’ll help me spread the word about the Fellowship. The time for innovation is now.

Please visit ThielFellowship.org to learn more.

Nanotechnology: How should we evaluate the environmental impact of human-made machines that are too small to see? What limits should be placed on self-replicating nanodevices? What defenses should we institute against malevolent uses of such technology?

These questions were asked by Marc Goodman, a senior advisor to Interpol and founder of Future Crimes Institute, a think tank that explores the security implications of new technology.  In a report by Ted Greenwald at Forbes.com, Goodman urged “aspiring captains of emerging industries like synthetic biology, robotics, and nanotech to take a proactive attitude toward their impact on the global community.”

Great to see this message of foresight reaching such a key audience, in addition to Ralph Merkle’s frequent briefings on nanotech at SU.  —Christine Peterson

Hope to see you there!  —Christine Peterson, President, Foresight Institute

See this page for schedule and link: http://foresight.org/reunion/schedule.html

It’s free so please have patience if we run into any technical difficulties.

You can try sending questions to speakers by using this Twitter tag (though in-person participants get first priority): #foresight2011

Next time we hope to see you in person!

As I write this, late conference registration is still open: http://www.eventbee.com/v/foresightinstitute/event?eid=890000225

(And note, the Friday evening no-host reception is open to all.)

—Chris Peterson

http://www.foresight.org/reunion
$50 off with code: NANODOT

You’ll be stimulated, enlightened and inspired by direct interaction with ground-breaking movers and shakers in transformative technologies, including:

Keynotes:
JIM VON EHR – President of Zyvex, the 1^st successful molecular nanotech company
BARNEY PELL – CoFounder/CTO of Moon Express competing for the Lunar X-PRIZE

Panels that will tempt you to ramp up your nanotech involvement:
·         The Scientific Challenges of Truly Transformative Nanotech
·         From Research to Application: Turning innovation into success

And emceed by SingularityU trustee SONIA ARRISON:
·         Funding, Development & the Valley of Death: Transcending entrepreneurial challenges
·         Jumpstarting a Career in Nanotech: How to make your move

Speakers and panelists include:
IBM’s THOMAS THEIS, Halcyon Molecular’s MICHAEL ANDREGG, Caltech’s WILLIAM GODDARD, ITRS ERM Chair MICHAEL GARNER, NanoInk CTO MIKE NELSON, Paypal’s LUKE NOSEK, Stanford forecaster PAUL SAFFO, motor-molecule creator SIR FRASER STODDART and more at:

Including plenty of schmooze time and topic-based lunch breakouts to maximize your access to speakers and key participants.

Free Friday night no-host reception at the Crowne Plaza Cabana in Palo Alto, and a special banquet for Senior Associates on Saturday night.  Hope to see you there! —Chris Peterson, President and Co-Founder, Foresight Institute