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	<title>Comments on: Will BioCDs Catch Our Diseases?</title>
	<atom:link href="http://www.foresight.org/nanodot/?feed=rss2&#038;p=1542" rel="self" type="application/rss+xml" />
	<link>http://www.foresight.org/nanodot/?p=1542</link>
	<description>examining transformative technology</description>
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		<title>By: RobertBradbury</title>
		<link>http://www.foresight.org/nanodot/?p=1542#comment-4333</link>
		<dc:creator>RobertBradbury</dc:creator>
		<pubDate>Tue, 25 May 2004 20:16:11 +0000</pubDate>
		<guid isPermaLink="false">http://www.foresight.org/nanodot/?p=1542#comment-4333</guid>
		<description>&lt;p&gt;&lt;strong&gt;Doubtful&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;I&#039;m not buying it Roland. It sounds like they need to coat each track on the CD with a different antibody (or other blood-protein attracting chemical). That is very different from the process of imprinting a CD with a representation of digital information.&lt;br /&gt;
&lt;br /&gt;
As pointed out &quot;Each ring of pits, or &#039;track,&#039; on the CD could be coated with a different protein,&quot;. Of course there is no discussion as to the cost of producing said proteins and or the limits with regard to applying them to the tracks on the CD. Of course one gets into questions about how the &quot;master&quot; would stamp the proteins onto the CD and/or how the proteins would individually be reapplied to the &quot;master&quot;. Though I am not an expert in CD manufacturing I strongly suspect that with music it is a generally non-destructive process -- i.e. each master can produce a large number of copies without degrading. The process described for BioCDS is inherently a destructive process -- i.e. each copy made requires the transfer of proteins from the master to the copy. You would be lucky to get 5-10 copies per master and each subsequent copy would be degraded as the concentration of proteins was diminished. So the reliability of any test results from a BioCD would be questionable.&lt;br /&gt;
&lt;br /&gt;
If one changes the CD manufacturing process so that one master is used per CD then one eliminates the cost advantages of CDs. I.e. the cost of each BioCD becomes very expensive.&lt;br /&gt;
&lt;br /&gt;
So while the idea may be interesting the viability of its implementation is very questionable.&lt;br /&gt;
&lt;br /&gt;
Also worthy of note -- while there may be variations in blood chemistry for some diseases there may be other diseases which take place entirely within cells (and are not indicated by changes in blood chemistry). So it remains an open question what fraction of human diseases could be detected by BioCDs even if they could be developed.&lt;br /&gt;
&lt;br /&gt;&lt;/p&gt;

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		<content:encoded><![CDATA[<p><strong>Doubtful</strong></p>
<p>I&#39;m not buying it Roland. It sounds like they need to coat each track on the CD with a different antibody (or other blood-protein attracting chemical). That is very different from the process of imprinting a CD with a representation of digital information.</p>
<p>As pointed out &quot;Each ring of pits, or &#39;track,&#39; on the CD could be coated with a different protein,&quot;. Of course there is no discussion as to the cost of producing said proteins and or the limits with regard to applying them to the tracks on the CD. Of course one gets into questions about how the &quot;master&quot; would stamp the proteins onto the CD and/or how the proteins would individually be reapplied to the &quot;master&quot;. Though I am not an expert in CD manufacturing I strongly suspect that with music it is a generally non-destructive process &#8212; i.e. each master can produce a large number of copies without degrading. The process described for BioCDS is inherently a destructive process &#8212; i.e. each copy made requires the transfer of proteins from the master to the copy. You would be lucky to get 5-10 copies per master and each subsequent copy would be degraded as the concentration of proteins was diminished. So the reliability of any test results from a BioCD would be questionable.</p>
<p>If one changes the CD manufacturing process so that one master is used per CD then one eliminates the cost advantages of CDs. I.e. the cost of each BioCD becomes very expensive.</p>
<p>So while the idea may be interesting the viability of its implementation is very questionable.</p>
<p>Also worthy of note &#8212; while there may be variations in blood chemistry for some diseases there may be other diseases which take place entirely within cells (and are not indicated by changes in blood chemistry). So it remains an open question what fraction of human diseases could be detected by BioCDs even if they could be developed.</p>
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