Comments on: Strong, stable DNA tetrahedra made quickly with high yield http://www.foresight.org/nanodot/?p=2116 examining transformative technology Wed, 03 Apr 2013 18:23:47 +0000 hourly 1 http://wordpress.org/?v=3.0.4 By: Robert Bradbury http://www.foresight.org/nanodot/?p=2116#comment-7382 Robert Bradbury Mon, 26 Dec 2005 17:15:49 +0000 http://www.foresight.org/nanodot/?p=2116#comment-7382 This sounds like nano-hype. Anyone with a knowledge of DNA hydrogen bonding and structure, or familiar with Nadrian Seemans work, would recognize that you can build self-assembling structures out of DNA. The yields are a function of how carefully you control the DNA sequences to avoid mismatched pairing as the self-assembly takes place. It is highly questionable as to whether you can use such structures as scaffolds for other work. The easy locations to vary in the DNA chemical structure are the specific bases which are within the structure itself. The DNA backbone is going to be on the outside of the structure and it is going to be much less easy to vary that and still build something. I question whether many things you will see published regarding nanoscale self-assembly will be able to pass the "non-obvious" test at the patent level. They might get by a patent examiner who is unfamiliar with the technology but I find it doubtful that they would stand up in court. (But bear in mind I am not a patent expert.) This gets a "yawn" from me, rather than a "That is *really* cool!" This sounds like nano-hype. Anyone with a knowledge of DNA hydrogen bonding and structure, or familiar with Nadrian Seemans work, would recognize that you can build self-assembling structures out of DNA. The yields are a function of how carefully you control the DNA sequences to avoid mismatched pairing as the self-assembly takes place. It is highly questionable as to whether you can use such structures as scaffolds for other work. The easy locations to vary in the DNA chemical structure are the specific bases which are within the structure itself. The DNA backbone is going to be on the outside of the structure and it is going to be much less easy to vary that and still build something.

I question whether many things you will see published regarding nanoscale self-assembly will be able to pass the “non-obvious” test at the patent level. They might get by a patent examiner who is unfamiliar with the technology but I find it doubtful that they would stand up in court. (But bear in mind I am not a patent expert.)

This gets a “yawn” from me, rather than a “That is *really* cool!”

]]> By: Alexander M Zoltai http://www.foresight.org/nanodot/?p=2116#comment-7349 Alexander M Zoltai Fri, 16 Dec 2005 23:31:23 +0000 http://www.foresight.org/nanodot/?p=2116#comment-7349 Is it to be assumed that these are primarily "scaffolds" to be used to build up other structures? Is it to be assumed that these are primarily “scaffolds” to be used to build up other structures?

]]> By: Anup Sheshadri http://www.foresight.org/nanodot/?p=2116#comment-7329 Anup Sheshadri Wed, 14 Dec 2005 08:46:28 +0000 http://www.foresight.org/nanodot/?p=2116#comment-7329 what are the benefits that we can get by synthesizing such 'complex DNA nanostructures'?is this going to provide cheaper and effective medicines than today? please provide me the knowledge of 'scope of these nanostructures' for humans, and animals and plants in general what are the benefits that we can get by synthesizing such ‘complex DNA nanostructures’?is this going to provide cheaper and effective medicines than today?
please provide me the knowledge of ‘scope of these nanostructures’ for humans, and animals and plants in general

]]> By: Deepankar Chatterjee http://www.foresight.org/nanodot/?p=2116#comment-7327 Deepankar Chatterjee Wed, 14 Dec 2005 04:36:46 +0000 http://www.foresight.org/nanodot/?p=2116#comment-7327 Will this help in the creation of some rudimentary inert virus, that can be used to place some important genetic modulational structure , produced by genetic engineers, into the body of any organism?. What is the level of stability of these structures?..... Any way... good job. I'll like to know more... Will this help in the creation of some rudimentary inert virus, that can be used to place some important genetic modulational structure , produced by genetic engineers, into the body of any organism?. What is the level of stability of these structures?….. Any way… good job. I’ll like to know more…

]]> By: Martin L. Burger http://www.foresight.org/nanodot/?p=2116#comment-7325 Martin L. Burger Tue, 13 Dec 2005 15:29:06 +0000 http://www.foresight.org/nanodot/?p=2116#comment-7325 This is incredible news and a major step forward. I would like to learn more about what it takes to get the 95% to 99.99% and thoughts, feel free to contact me. This is incredible news and a major step forward.
I would like to learn more about what it takes to get the 95% to 99.99% and
thoughts, feel free to contact me.

]]>