http://www.foresight.org/nanodot/?p=2724 examining transformative technology Wed, 03 Apr 2013 18:23:47 +0000 hourly 1 http://wordpress.org/?v=3.0.4 http://www.foresight.org/nanodot/?p=2724#comment-591189 Xiaogan Liang Thu, 22 May 2008 20:04:51 +0000 http://www.foresight.org/nanodot/?p=2724#comment-591189 100 nm channel width is too large to completely linearize the DNA strands, considering that dsDNA has a persistence length ~ 50 nm; ssDNA with ~10 nm persistence length. Even the DNA can be well linearized in the channel, more device structure will be needed to detect the information associated with the single bases for sequencing purpose. Such deivce structure has to be as small as sub-2 nm, because of the typical dimenion parameters related to the single base: width of ~ 2 nm, length of single base ~ 0.34 nm. Not easy! 100 nm channel width is too large to completely linearize the DNA strands, considering that dsDNA has a persistence length ~ 50 nm; ssDNA with ~10 nm persistence length. Even the DNA can be well linearized in the channel, more device structure will be needed to detect the information associated with the single bases for sequencing purpose. Such deivce structure has to be as small as sub-2 nm, because of the typical dimenion parameters related to the single base: width of ~ 2 nm, length of single base ~ 0.34 nm. Not easy!

]]> http://www.foresight.org/nanodot/?p=2724#comment-567995 Prof P.Pramanik Thu, 01 May 2008 11:33:18 +0000 http://www.foresight.org/nanodot/?p=2724#comment-567995 The idea is exciting but error of reading will be tremndous because DNA will not flow like a rod . So it needs some advance technology of reading. Prof P.Pramanik nano-materials laboratory Indian Institute of technology , Kharagpur 721302, INDIA The idea is exciting but error of reading will be tremndous because DNA will not flow like a rod .
So it needs some advance technology of reading.
Prof P.Pramanik
nano-materials laboratory
Indian Institute of technology , Kharagpur 721302, INDIA

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