Comments on: Reading DNA sequences from single molecules of polymerase using nanotechnology http://www.foresight.org/nanodot/?p=2919 examining transformative technology Wed, 03 Apr 2013 18:23:47 +0000 hourly 1 http://wordpress.org/?v=3.0.4 By: http://www.foresight.org/nanodot/?p=2919#comment-800217 Wed, 07 Jan 2009 02:09:33 +0000 http://www.foresight.org/nanodot/?p=2919#comment-800217 As the sequences get longer, aren't you going to have more trouble ensuring that only one piece of DNA arrives in each well? As the sequences get longer, aren’t you going to have more trouble ensuring that only one piece of DNA arrives in each well?

]]> By: http://www.foresight.org/nanodot/?p=2919#comment-800103 Tue, 06 Jan 2009 22:20:43 +0000 http://www.foresight.org/nanodot/?p=2919#comment-800103 Now we need to add a Quantum Computer and Grovers algorithm. http://www.dwavesys.com/ http://en.wikipedia.org/wiki/Grover's_algorithm This would allow exhaustive DNA searches of many genomes simultaneously. The real advance will not be cheap human genomes it will rather be all the other species genomes we could compare to the human genome to gain context of the expressions of the human genomes 18K genes. By comparative genomics we will finally understand the functions of genes. This epigenetics revolution may eventually lead to human life extension. A recent advance in creating a cell phone microscope may lead to massive sequencing of all 7 billion people. http://science.slashdot.org/article.pl?sid=08%2F12%2F20%2F2012230&from=rss http://www.wired.com/science/discoveries/multimedia/2008/12/gallery_microscope_phone If a cell phone microarray can be developed genomic information can be read in the field any where. CSI to WHO. http://www.mailman.hs.columbia.edu/news/Lipkin_GreeneChip.html Now we need to add a Quantum Computer and Grovers algorithm.
http://www.dwavesys.com/
http://en.wikipedia.org/wiki/Grover‘s_algorithm
This would allow exhaustive DNA searches of many genomes simultaneously.
The real advance will not be cheap human genomes it will rather be all the other species genomes we could compare to the human genome to gain context of the expressions of the human genomes 18K genes. By comparative genomics we will finally understand the functions of genes.
This epigenetics revolution may eventually lead to human life extension.

A recent advance in creating a cell phone microscope may lead to massive sequencing of all 7 billion people.
http://science.slashdot.org/article.pl?sid=08%2F12%2F20%2F2012230&from=rss
http://www.wired.com/science/discoveries/multimedia/2008/12/gallery_microscope_phone
If a cell phone microarray can be developed genomic information can be read in the field any where. CSI to WHO.
http://www.mailman.hs.columbia.edu/news/Lipkin_GreeneChip.html

]]> By: http://www.foresight.org/nanodot/?p=2919#comment-799946 Tue, 06 Jan 2009 12:39:21 +0000 http://www.foresight.org/nanodot/?p=2919#comment-799946 All by myself All by myself

]]> By: http://www.foresight.org/nanodot/?p=2919#comment-799945 Tue, 06 Jan 2009 12:37:34 +0000 http://www.foresight.org/nanodot/?p=2919#comment-799945 I took a shower today I took a shower today

]]> By: Nuve metodiche di sequenza del DNA « Daemons & Dependancies http://www.foresight.org/nanodot/?p=2919#comment-799844 Nuve metodiche di sequenza del DNA « Daemons & Dependancies Tue, 06 Jan 2009 07:53:30 +0000 http://www.foresight.org/nanodot/?p=2919#comment-799844 [...] Nuve metodiche di sequenza del DNA “A new method of DNA sequencing published this week in science identifies incorporation of single bases by fluorescence. This has been shown to increase read lengths from 20 bases (454 sequencing) to >4000 bases, with a 99.3% accuracy. Single molecule reading can reduce costs and increase the rate at which reads can be performed. ‘So far, the team has built a chip housing 3000 ZMWs [waveguides], which the company hopes will hit the market in 2010. By 2013, it aims to squeeze a million ZMWs [waveguides] onto a single chip and observe DNA being assembled in each simultaneously. Company founder Stephen Turner estimates that such a chip would be able to sequence an entire human genome in under half an hour to 99.999 per cent accuracy for under $1000.’” [...] [...] Nuve metodiche di sequenza del DNA “A new method of DNA sequencing published this week in science identifies incorporation of single bases by fluorescence. This has been shown to increase read lengths from 20 bases (454 sequencing) to >4000 bases, with a 99.3% accuracy. Single molecule reading can reduce costs and increase the rate at which reads can be performed. ‘So far, the team has built a chip housing 3000 ZMWs [waveguides], which the company hopes will hit the market in 2010. By 2013, it aims to squeeze a million ZMWs [waveguides] onto a single chip and observe DNA being assembled in each simultaneously. Company founder Stephen Turner estimates that such a chip would be able to sequence an entire human genome in under half an hour to 99.999 per cent accuracy for under $1000.’” [...]

]]> By: http://www.foresight.org/nanodot/?p=2919#comment-799774 Tue, 06 Jan 2009 00:44:41 +0000 http://www.foresight.org/nanodot/?p=2919#comment-799774 This independent authority doesn't sound too smart. There are 3000 waveguides on the current chip at 150bases per waveguide for 450,000 bases. Granted it is still a long jump from 450,000 to 3 billion, but the jump is much smaller. Also, the only thing they have to do is increase the number of waveguides. The hard part appears to be done (i.e. getting the tehcnology to work at all). This independent authority doesn’t sound too smart. There are 3000 waveguides on the current chip at 150bases per waveguide for 450,000 bases. Granted it is still a long jump from 450,000 to 3 billion, but the jump is much smaller. Also, the only thing they have to do is increase the number of waveguides. The hard part appears to be done (i.e. getting the tehcnology to work at all).

]]> By: http://www.foresight.org/nanodot/?p=2919#comment-797324 Mon, 29 Dec 2008 01:20:26 +0000 http://www.foresight.org/nanodot/?p=2919#comment-797324 Er, you don't want to jump from 150 to 3 billion bases. Read up on shotgun sequencing. The mere fact that a given chunk is 150 bases is immaterial, though of course if you could lengthen that by a factor of five or ten it would improve accuracy and reduce computation on assembling the whole thing. Er, you don’t want to jump from 150 to 3 billion bases. Read up on shotgun sequencing. The mere fact that a given chunk is 150 bases is immaterial, though of course if you could lengthen that by a factor of five or ten it would improve accuracy and reduce computation on assembling the whole thing.

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