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Nanosphere presents Success of Novel Technology

Wendy Emanuel writes "Northbrook, Ill. ñ January 26, 2005 ñ Researchers at Nanosphere, Inc. today reported unprecedented benefits in the companyís technology for the medical analysis of human DNA. Nanosphereís nanoparticle-based technology allows for rapid, highly-sensitive and specific Single Nucleotide Polymorphism (SNP) genotyping, which is the direct detection of a particular gene and the extent to which it is normal or mutated.

More… The technology, reported in the February 2005 (Volume 33, Number 2), issue of Nucleic Acids Research, allows detection of a SNP in an unknown genotype with a greater than 99 percent confidence threshold and can be used with human DNA obtained from samples as small as a drop of blood. Importantly, the technology eliminates the need for costly, time and labor intensive gene amplification or enzymatic interventions ñ two widespread methods currently used to perform such analyses.

"Nanosphereís new SNP analysis methodology for whole genomic human DNA is a powerful example of the versatility of our proprietary ClearReadô nanoparticle technology," said William Moffitt, Nanosphere's President and CEO. "This study and the use of nanoparticles to dramatically increase sensitivity in our other proprietary applications — such as bio-barcode for ultra sensitive detection of proteins — demonstrate the broad applicability of nanotechnology and its potential to markedly advance the state-of-the-art in nucleic acid and proteomic research and diagnostics."

The analysis of whole human genomic DNA is extraordinarily complex as it requires sifting through the more than one billion base pairs of DNA to find a particular base pair of interest. Once that base pair is located, it is then necessary to determine if either of the bases is mutated (i.e., has SNPs). Nanosphereís technology can rapidly, easily, and accurately interrogate both bases in the pair to determine if they are homozygous (i.e., both are mutant or normal) or heterozygous (i.e., one is mutant, one is normal) ñ the most critical step in correlating the SNP with a disease or drug sensitivity.

To do so, Nanosphere scientists employ a two-step process called ClearReadô technology. This method sandwiches a target DNA SNP segment between two oligonucleotide sequences to greatly increase detection specificity and sensitivity. One segment identifies any mutations in the DNA and the probe, a highly sensitive gold nanoparticle, creates a strong signal accurately indicating the presence of a specific target SNP. Proof of principle, reproducibility, and the robust, simple and rapid characteristics of this technology were demonstrated with unamplified DNA samples representing all possible forms of three genes implicated in hypercoagulation disorders.

Nanosphere (www.nanosphere-inc.com) is a nanotechnology-based life sciences company in Northbrook, Illinois that is using the application of proprietary nanotechnology to create new standards in medical care and public safety. With a universal Verigeneô product platform for the detection of nucleic acids and proteins, Nanosphere is rapidly advancing the development of assays for genomic and proteomic research, clinical laboratories and point-of-care markets."

24 Responses to “Nanosphere presents Success of Novel Technology”

  1. Laura Sacks Says:

    I am e-mailing you in hopes that you can help me. I am being approached to do some consulting for a firm which claims that they are using Nanosphere Technology in their hair and skin care products and that it is a most wonderful product. What can you tell me about this technology being used in this industry. Thank you for your time.

  2. Corey Bock Says:

    Dear Laura, I am considering Arbonne products which boast of using nanosphere technology in formulating their hair and skin products. I am wondering what you learned of its actual benefits. Thank you,

    Corey Bock

  3. Jessica Welch Says:

    I am also curious about this subject. Please email me ANY information.

    Thank you,
    Jessica Welch

  4. Tia Wilson Says:

    Would also like info on this subject.

    Thank you’
    Tia Wilson

  5. Jennifer Smith Says:

    Hello Laura, I am also cerious about the Nanophere prouducts that are used in Arbonne. Exactly how it works and the benifits of Nanosphere Technology??

    Thank You
    Jennifer Smith

  6. PATRICIA BELL Says:

    hello;

    I AM ALSO CURIOUS ABOUT HOW NANOPHERE TECHNOLOGY WORKS WITH SKIN AND HAIR PRODUCTS AS STATED BY ARBONNE.

    WHAT ARE THE BENIFITS OF SUCH????

    THANK YOU

    PATRICIA BELL

  7. Robin G Says:

    Hello,

    Is nanotechnology for real in skincare? How do they do it, and keep the beneficial ingredients inside, and deliver the good stuff to the skin appropriately? Could you please e-mail me with your opinion?

    Thanks!

  8. Adam Says:

    I am a consultant for Arbonne International, (products containing nanosphere technology) and just read that nanosphere technology is being used for cancer patients. What exactly is “nanosphere technology” and how is it being used in the areas of health and beauty? I would greatly appreciate your response. THANKS!

  9. Rebecca Says:

    I am also very interested in Nanosphere Technology in the field of hair and skin products and how it work?? Any info would be greatly appreciated!!

  10. Jennifer Says:

    It seems to be a popular subject this Nanoshpere Technology, I am wanting information as well. As a new Arbonne consultant I would like to know exactly what it is I am using and selling to friends and family. Please email me as much information as you can.
    Thanks,

  11. Gay Says:

    Would also like info on safety in connection with nanosphere technology and skin care products (Arbonne).
    Thanks.

  12. Jennifer Says:

    Would also like info on nanosphere technology in cosmetics…as I’m considering selling Arbonne. Thanks so much

  13. Tina Says:

    I am also researching nanosphere technology because I am selling Arbonne. I would like to know how it works (if it works) so I can explain it to people.

    I would appreciate it if you could e-mail me some information.

    Thanks a bunch.

  14. M.O. Says:

    I am also doing some research on nanosphere technology. I would like to know how it works (if it works) so I can explain it to people that may purchase skin care products. Thank you

  15. Nisha Says:

    Please send the answers to the above questions to me also. I’m curious about nanosphere technology in skin and hair care. Thanks!!

  16. Kim W Says:

    I would like more information about nanosphere technology, specifically how it works, if it works, if it (or the products it delivers) is delivered to the brain, and if we should have such delivery with cosmetics? Thank you in advance!

  17. Kim S. Says:

    I am considering becoming a consultant for Arbonne and I know they use products with nanosphere technology in them and I was wondering if you could tell me about it? Safety issues, how it is beneficial to you, anything about it. I want to know what is in the products I am using and selling to my family and friends. If you could email me some inforamtion that could be helpful and of use.
    Thank you,
    Kim S.

  18. Michele O. Says:

    I have also been using Arboone products and am considering becoming a cpnsultant. Could you please give me more information about this technology being used in skin care products and it’s safety.
    Thank you.

  19. N. Fowler Says:

    I am an Independent Consultant with Arbonne International, and I recently heard about an article that said to stay away from nano technology because of safety issues. I heard something about ingredients from the products getting into the liver? Is this technology safe in skin care? Should I have any concerns? Thank You.

  20. Karen Cardillo Says:

    I’d be interested to know what responses people have received. I’d like answers to all of the questions posted above also. If anyone has actually received a response regarding Arbonne’s use of Nanosphere technology, can you post it here?

  21. Raquel Salati Says:

    I would like to receive the responses from the questions above as well. I’m also interested in learning how the nanosphere technology is used in skin care products. I have been using Arbonne and I just read about this technology. Thank you in advance for your help.

  22. Meg Says:

    I, too, am interested in all of the above questions and would love any and all information forwarded to me regarding Arbonne’s use of Nanoshpere technology.

  23. Says:

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  24. Ka Wai kwan Says:

    I would like to know if the Arbonne products contain nanoparticles. Would it be harmful if the ingrediants penatrate to skin and to your blood stream and will it cause cancer?
    Please email me, thanks!

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