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Massive nanotechnology review resolves hard/soft dispute

Here on Nanodot we mentioned earlier a nanotechnology survey article titled Synthetic Molecular Motors and Mechanical Machines by Euan Kay, David Leigh, and Francesco Zerbetto. I have a paper copy now and have to admit that it is indeed worth $25, but that the 24-hour online access offered by the publisher at that price would not be nearly enough. This tome could be a book. Presumably an online purchase enables downloading for later viewing.

I have not read the whole thing, and probably never will — this is for serious researchers. However, I was glad to see the conclusion address and, in my view, resolve the ongoing fuss of whether molecular machine systems should be built using the “hard matter” approach inspired by physics and engineering or the “soft matter” approach inspired by biology. This was always an unnecessary dispute, as the paper makes clear:

As outlined in this Review, both sets of design philosophies have already had many notable successes and they are not mutually exclusive. No doubt their combination will become increasingly important in the future.

The article also disposes of the complexity argument against artificial molecular machine systems:

In this regard, we do not subscribe to the view that it will be impossible for synthetic chemists to develop molecular-level machine systems that use controlled motion to perform functions similar to those of biological machines simply because of the complexity of the latter (just as the tremendous successes in homogeneous and heterogeneous catalysis have been achieved without the need for the de novo design of enzymes).

Quite so. For Nanodot readers unable to afford $25 for one article, no matter how lengthy, author David Leigh has offered to send an electronic version. See the comment by Dave L. —Christine

4 Responses to “Massive nanotechnology review resolves hard/soft dispute”

  1. Kurt9 Says:

    In other words, it sounds like we will get real nanotech (dry and wet) after all.

  2. anonimouse Says:

    Christine, if you go to the website for Angewandte Chemie International Edition you’ll find that you can do a free registration, which will give you full access to the first issue, containing the article in question, as a “sample copy” for a limited time. So save your $25 and don’t advise your readers to bug the author.

  3. Nanoman Says:

    How do I buy a PAPER COPY of this???

  4. Kurt9 Says:

    I’ve downloaded and read this paper. It is complicated and quite comprehensive. The general characterisitics of the nanotech presented in this paper is that it is based on aqueous (solution-phase) chemistry and that all of the developed and proposed reaction mechanisms are based on the utilization of Brownian motion. Yes, there is directional control of reactant molecules, but it still occurs within the context of this general background.

    Based on this paper alone, it would be reasonable to conclude that the future molecular manufacturing will be based overwhelmingly on “wet” nanotechnology, rather than “dry” nanotechnology.

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