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Magnetic nanoparticles to cook brain cancer go into trial in patient

Nanotechnology has been applied to produce various types of nanoparticles that can deliver toxic agents specifically to the cancer cells. Many of these approaches have shown promise in animal studies. One approach using magnetic nanoparticles has now gone into trials in patients. From “Nano-therapy that cooks deadly brain tumors advances in Germany,” by Ryan McBride:

Nanotechnology experts have been tackling the monster task of combating aggressive brain tumors that can’t be beat with chemotherapy and radiation treatments alone. This week MagForce reported that its therapy, which involves heating magnetic nanoparticles in tumor cells, was initiated in a patient with a form of brain cancer called glioblastoma at the University of Giessen in Germany.

While the “NanoTherm” therapy was cleared for the market in EU countries last year, it’s still regarded in the medical community as a relatively novel approach to treating the aggressive brain tumors. Germany-based MagForce has been laboring for years to bring the treatment to market, and the firm had been planning to release the product this year. This week’s news says that the company has begun the treatment in patients in Germany as planned and the country’s state insurance covered the cost under “an individual patient agreement.”

At the University of Giessen, the patient with the brain cancer got an injection of the firm’s magnetic nanoparticles into the tumor site. The aminosaline [sic—should say "aminosilane"] coatings on the iron oxide nanoparticles enable the nanoparticles to aggregate. The patient went to Charité University Medical Center Berlin for the next step of the therapy, which involves applying a magnetic field to rapidly move the nanoparticles and heat them up in order to kill the tumor cells or make them more responsive to chemo or radiation therapy. …

The MagForce web page explains that the aminosilane coating that enables the nanoparticles to aggregate also causes them to stay in place, making repeated treatments possible. This is a potential advantage over other approaches in which nanoparticles would have to be administered with each treatment. Unlike other approaches that rely upon molecules that bind specifically to cancer cells, this approach relies upon localizing the tumor and injecting the nanoparticles directly into the tumor. Only clinical trials will be able to determine which, if any, approaches are clinically effective in which cancers.

4 Responses to “Magnetic nanoparticles to cook brain cancer go into trial in patient”

  1. nbic and emerging technology 10/13/2011 « no brave new world Says:

    [...] Magnetic nanoparticles to cook brain cancer go into trial in patient [...]

  2. Frank Randall Says:

    A related procedure injects nanoparticles into the patient. The nanoparticles go to the cancer site and a radio-frequency machine, invented by John Kanzius, zaps them. It has eradicated tumors in small animals, such as rabbits and mice, and is currently being researched at MD Anderson by a team headed by Dr. Steve Curley. The huge advantage to this procedure, if proven ultimately successful with humans, is that the nanoparticles do not have to be injected directly into the tumor; thus, more tumors can be reached. Also, no cancer drugs are used and tumors that have mastesized can, potentially, be reached. This procedure is about 2 yrs. away from being approved.

  3. NanoMan Says:

    I was doing some investigation into diamond synthesis and I found this. I was totally amazed. I know we can make diamonds using high pressures, and high temperatures, and now we can do it using high temperatures in chemical vapor deposition, but, this is even greater. Scientists have used ultra sound cavitation processes to produce micro sized diamonds in a liquid medium. This shows that we can definitely synthesize diamond using mechanical force, even though this was already known. Here are the relevant links and information:

    http://www.sciencedirect.com/science…25963508001374

    From the paper:

    ” Graphite-to-diamond transformation induced by ultrasound cavitation

    A.Kh. Khachatryana, c, S.G. Aloyana, Corresponding Author Contact Information, E-mail The Corresponding Author, P.W. Mayb, R. Sargsyana, V.A. Khachatryana, V.S. Baghdasaryand
    Purchase
    a Institute of General and Inorganic Chemistry of Armenian National Academy of Sciences, 10 Argutyan 2 District, 0051, Yerevan, Armenia
    b School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 ITS, U.K.
    c Institute of Chemical Physics of Armenian National Academy of Sciences 5/2 Paruir Sevak St., 0044 Yerevan, Armenia
    d Yerevan Physics Institute 2 Alikhanian Br. St., 0036 Yerevan, Armenia

    Received 5 September 2007; revised 14 January 2008; Accepted 24 January 2008. Available online 13 February 2008.
    Abstract

    Diamond microcrystals have been synthesized using ultrasonic cavitation of a suspension of hexagonal graphite in various organic liquid media, at an average bulk temperature of the liquid up to 120°C and at atmospheric pressure. The yield of diamond is up to 10% by mass. The diamonds were characterized by scanning electron microscopy, X-ray diffraction and laser Raman spectroscopy. Analysis of the crystallite size distribution showed that the diamonds were nearly mono-dispersed, having a size 6 or 9μm ± 0.5μm, with cubic, crystalline morphology.”

    Here is a quote from Wikipedia:

    Micron-sized diamond crystals can be synthesized from a suspension of graphite in organic liquid at atmospheric pressure and room temperature using ultrasonic cavitation. The diamond yield is about 10% of the initial graphite weight. The estimated cost of diamond produced by this method is comparable to that of the HPHT method; the crystalline perfection of the product is significantly worse for the ultrasonic synthesis. This technique requires relatively simple equipment and procedures, but it has only been reported by two research groups, and has no industrial use as of 2009[update]. Numerous process parameters, such as preparation of the initial graphite powder, the choice of ultrasonic power, synthesis time and the solvent, are not yet optimized, leaving a window for potential improvement of the efficiency and reduction of the cost of the ultrasonic synthesis.

    And here is another link:

    http://resources.metapress.com/pdf-p…7&size=largest

    http://www.springerlink.com/content/fg40t5787h828337/

    This is very good news for those who want diamonds to be synthesized.

  4. Magnetic nanoparticles to cook brain cancer go … – Foresight Institute | Brain cancer Stories Says:

    [...] the rest here: Magnetic nanoparticles to cook brain cancer go … – Foresight Institute This entry was posted in brain cancer and tagged called-glioblastoma, giessen, heating-magnetic, [...]

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