Nanodot: the original nanotechnology weblog
Posted by Jim Lewis on October 3rd, 2014
The image shows a hypothetical molecular assembly line where reagents are effectively added to a growing carbon chain with extraordinary high fidelity and precision. By controlling the precise orientation of the building blocks added to the carbon chain, the conformation of the molecule can be controlled so that it adopts a helical (shown) or linear shape. Credit: Amber Webster, www.amberlwebster.com
To develop a productive nanosystem for molecular manufacturing/atomically precise manufacturing it would be very useful to have a nanoscale assembly line. A month ago we posted here about a proof of principle for one such assembly line based upon biomolecules. This month Christine Peterson sends word of an assembly line for complex artificial organic molecules. An article on SingularityHUB led to this news release from the University of Bristol “Chemists create ‘assembly-line’ for organic molecules“:
Scientists at the University of Bristol have developed a process where reagents are added to a growing carbon chain with extraordinary high fidelity and precise orientation, thereby controlling the conformation of the molecule so that it adopts a helical or linear shape. The process can be likened to a molecular assembly line.
Nature has evolved highly sophisticated machinery for organic synthesis. One of the most beautiful examples is its machinery for the synthesis of polyketides, a very important class of molecules due to their broad spectrum of biological activities (for example antibiotic, antitumor, antifungal, antiparasitic).
In this process, a simple thioester (small building block) is passed from one enzyme domain to another, growing as it does so until the target molecule is formed. The process resembles a molecular assembly line.
The Bristol researchers sought to emulate nature in the construction of their own molecular assembly line through a related iterative process. But iterative processes are very challenging as each iteration must occur with >99.5 per cent efficiency, and >99.5 per cent stereocontrol otherwise mixtures would result.
In a paper published in the journal Nature today [abstract], the scientists report a reagent which reacts with their small building blocks (boronic esters) with exceptionally high fidelity and stereocontrol.
Through repeated iteration they have converted a simple building block into a complex molecule (a carbon chain with ten contiguous methyl groups) with remarkably high precision over its length, its stereochemistry and therefore its shape.
Different stereoisomers were targeted and it was found that they adopted different shapes (helical/linear) according to their stereochemistry.
This work should now enable molecules with predictable shape to be rationally designed and created which could have an impact in all areas of molecular sciences where bespoke molecules are required.
The ability demonstrated here to control the spatial configuration of the addition of each new subunit of a long molecule to achieve programmable molecular shapes is certainly a useful step toward a molecular assembly line. One interesting question is how many specially designed or specially chosen building blocks and reagents will be needed to construct a generally useful molecular assembly line.
—James Lewis, PhD
Posted by Jim Lewis on September 27th, 2014
Speaking of US government programs to advance nanomanufacturing, Christine Peterson sends word of a US National Science Foundation nanomanufactring program that explicitly mentions nanorobots and other nanomachines “The NSF Nanomanufacturing Program“:
… The NSF Nanomanufacturing Program supports fundamental research in novel methods and techniques for batch and continuous processes, top-down (addition/subtraction) and bottom-up (directed self-assembly) processes leading to the formation of complex heterogeneous nanosystems. The program supports basic research in nanostructure and process design principles, integration across length-scales, and system-level integration. The Program leverages advances in the understanding of nano-scale phenomena and processes (physical, chemical, electrical, thermal, mechanical and biological), nanomaterials discovery, novel nanostructure architectures, and new nanodevice and nanosystem concepts. It seeks to address quality, efficiency, scalability, reliability, safety and affordability issues that are relevant to manufacturing. To address these issues, the Program encourages research on processes and production systems based on computation, modeling and simulation, use of process metrology, sensing, monitoring, and control, and assessment of product (nanomaterial, nanostructure, nanodevice or nanosystem) quality and performance.
The Program seeks to explore transformative approaches to nanomanufacturing, including but not limited to: micro-reactor and micro-fluidics enabled nanosynthesis, bio-inspired nanomanufacturing, manufacturing by nanomachines, additive nanomanufacturing, hierarchical nanostructure assembly, continuous high-rate nanofabrication such as roll-to-roll processing or massively-parallel large-area processing, and modular manufacturing platforms for nanosystems. The Program encourages the fabrication of nanomaterials by design, three-dimensional nanostructures, multi-layer nanodevices, and multi-material and multi-functional nanosystems. Also of interest is the manufacture of dynamic nanosystems such as nanomotors, nanorobots, and nanomachines [emphasis added], and enabling advances in transport and diffusion mechanisms at the nano-scale. …
The description of the program is broad enough to cover numerous topics relevant to both the integration of current nanomaterials and nanodevices into near-term nanofabricated products across a wide range of applications, and progress toward productive nanosystems and atomically precise manufacturing. It will be interesting to see what research actually gets funded by this program.
—James Lewis, PhD
Posted by Jim Lewis on September 26th, 2014
A PowerPoint slide shows the two technical areas DARPA’s Atoms to Product project will concentrate on. (Slide courtesy of DARPA)
A few weeks ago we posted the announcement of a new DARPA program, the Atoms To Product (A2P) project. For those who were not able to catch the webinar explaining the initiative, more information is available in an article on Fedscoop “DARPA wants help closing nanotechnology’s ‘assembly gap’:
The Pentagon’s advanced research agency wants to do something that currently cannot be done: Take things built at a really, really small level and scale them for production in really big systems.
Solving that problem will be the task of those behind the Atoms To Product (A2P) project at the Defense Advanced Research Projects Agency’s Defense Sciences Office. DARPA is soliciting proposals for how researchers can further advance and leverage nanotechnology.
Stephanie Tompkins, director of the Defense Sciences Office, said the project fits into two of the office’s main focal points: finding ways to adapt to a growing market of globally available technology and incorporating it into military systems. Currently, technology is moving too fast and the adoption costs are unsustainable for military systems. DARPA hopes the A2P project will provide a cheaper way to integrate new technology on a variety of scales. …
A2P will focus on two technical links in the scaling hierarchy: moving atomic-level tech into the micron or molecule level, then moving the micron level into the millimeter level. The atoms-to-micron level will produce what’s known as feedstock — raw materials used in product manufacturing — with that material eventually allowing scientists to move it into millimeter-sized components. …
Yesterday’s post on extensions to the scaffolded DNA origami method fall toward the far end of the TA1 step in the above slide, the atoms to micrometer step. Perhaps the real challenge remaining in this first step is not an increase in scale per se, since the 300 nm by 200 nm DNA arrays are only a factor of three from the micrometer scale, but a way to use these arrays as organizing scaffolds for methods to make an array of molecules much wider than the world of biomolecules.
—James Lewis, PhD
Posted by Jim Lewis on September 25th, 2014
Scaffolded DNA origami utilizes numerous chemically synthesized, short DNA strands (staple strands) to direct the folding of a larger, biologically derived strand of DNA (scaffold strand). Molecular recognition (base pairing, i.e., A binds to T and G binds to C) directs the DNA to self-assemble into a specific structure as programed by the staple strand sequences. Unique staple strands produce a molecular pegboard with single-digit nanometer site-specificity precision. The atomic force microscopy image (right) demonstrates the final origami structure. Image credit: Alexandria Marchi.
Scaffolded DNA origami provided the starting point for the modular molecular composite nanosystems approach to atomically precise productive nanosystems (see Productive Nanosystems: A Technology Roadmap PDf page x, page 51). Over the past seven years we have pointed here to numerous advances in structural DNA nanotechnology and the related underlying technologies as advances toward atomically precise manufacturing, but one limit has been the maximum size available of the conventional single stranded scaffold available from the bacteriophage M13, which limits the scale of the uniquely addressable DNA structures that can be built. A second limit has been the cost of synthesis of the DNA staple strands. Now both of those limits have been greatly extended. A hat tip to ScienceDaily for reprinting this North Carolina State University news release “Researchers Create World’s Largest DNA Origami“:
Researchers from North Carolina State University, Duke University and the University of Copenhagen have created the world’s largest DNA origami, which are nanoscale constructions with applications ranging from biomedical research to nanoelectronics.
“These origami can be customized for use in everything from studying cell behavior to creating templates for the nanofabrication of electronic components,” says Dr. Thom LaBean, an associate professor of materials science and engineering at NC State and senior author of a paper describing the work.
Read the rest of this entry »
Posted by Jim Lewis on September 14th, 2014
Schematic illustration of construction of a multifunctional nanoparticle (credit: Yuanpei Li et al./Nature Communications)
A variety of nanoparticles have been designed for multiple nanomedical purposes. An article at KurzweilAI.net presents news from UC Davis of a “nanoporphyrin” platform for developing multifunctional nanoparticles based upon treelike dendrimer structures made using porphyrin, cholic acid, amino acids, and polyethylene glycol “A multifunctional medical nanoparticle“:
Researchers at UC Davis Comprehensive Cancer Center and other institutions have created biocompatible multitasking nanoparticles that could be used as contrast agents to light up tumors for MRI and PET scans or deliver chemo and other therapies to destroy tumors. The study was published online in Nature Communications [abstract].
Read the rest of this entry »
Posted by Jim Lewis on September 2nd, 2014
The assembly carrier moves through several reaction chambres where different molecules bind to its surface. The graph below shows the trajectory of a single shuttle. (Graphics: from Steuerwald et al. 2014)
One step toward nanofactories for atomically precise manufacturing would be the development of nanoscale production lines for assembling molecular cargo or other nanostructures into larger functional devices. Over the past few years we have cited here various advances toward this goal based on structural DNA nanotechnology, such as DNA walkers moving along tracks formed by DNA origami: DNA-based ‘robotic’ assembly begins (2010), DNA molecular robots learn to walk in any direction along a branched track (2011), AFM visualization of molecular robot moving along DNA scaffold (with video) (2011), and DNA motor navigates network of DNA tracks (2012). Back in 2006 another possibility was pointed out by bionanotechnologist Viola Vogel, working with natural motor proteins and cytoskeletal components, in an interview cited here: “Maybe in the future we can build an assembly line to assemble nanosystems into working devices, like a car assembly line, but at the nanoscale.” The future has apparently arrived. A hat tip to nanotech-now for drawing our attention to this news release from Prof. Vogel’s group at ETH Zürich announcing an important proof of principle demonstration “Nanoscale assembly line“:
ETH researchers have realised a long-held dream: inspired by an industrial assembly line, they have developed a nanoscale production line for the assembly of biological molecules.
Cars, planes and many electronic products are now built with the help of sophisticated assembly lines. Mobile assembly carriers, on to which the objects are fixed, are an important part of these assembly lines. In the case of a car body, the assembly components are attached in various work stages arranged in a precise spatial and chronological sequence, resulting in a complete vehicle at the end of the line.
The creation of such an assembly line at molecular level has been a long-held dream of many nanoscientists. “It would enable us to assemble new complex substances or materials for specific applications,” says Professor Viola Vogel, head of the Laboratory of Applied Mechanobiology at ETH Zurich. Vogel has been working on this ambitious project together with her team and has recently made an important step. In a paper published in the latest issue of the Royal Society of Chemistry’s Lab on a Chip journal ["Nanoshuttles propelled by motor proteins sequentially assemble molecular cargo in a microfluidic device" abstract; full text requires payment], the ETH researchers presented a molecular assembly line featuring all the elements of a conventional production line: a mobile assembly carrier, an assembly object, assembly components attached at various assembly stations and a motor (including fuel) for the assembly carrier to transport the object from one assembly station to the next.
Read the rest of this entry »
Posted by Jim Lewis on September 1st, 2014
Image courtesy of DARPA
One of the most innovative funding agencies has announced a new program aimed at assembling three-dimensional systems from the “atomic scale.”
DARPA will explain the new initiative in a webinar on September 9 and 11. Deadline for registering is September 5 at 5 PM Eastern time for US citizens; see the DARPA site for non-US citizen registration info.
Those of us who pursue atomically-precise manufacturing will want to view this webinar http://www.darpa.mil/NewsEvents/Releases/2014/08/22.aspx:
ATOMS TO PRODUCT: AIMING TO MAKE NANOSCALE BENEFITS LIFE-SIZED
New program also seeks to develop revolutionary miniaturization and assembly methods that would work at scales 100,000 times smaller than current state-of-the-art technology.
Many common materials exhibit different and potentially useful characteristics when fabricated at extremely small scales—that is, at dimensions near the size of atoms, or a few ten-billionths of a meter. These “atomic scale” or “nanoscale” properties include quantized electrical characteristics, glueless adhesion, rapid temperature changes, and tunable light absorption and scattering that, if available in human-scale products and systems, could offer potentially revolutionary defense and commercial capabilities. Two as-yet insurmountable technical challenges, however, stand in the way: Lack of knowledge of how to retain nanoscale properties in materials at larger scales, and lack of assembly capabilities for items between nanoscale and 100 microns—slightly wider than a human hair.
Read the rest of this entry »
Posted by Jim Lewis on August 31st, 2014
Dr. Richard Jones
Long-term readers of Nanodot will be familiar with the work of Richard Jones, a UK physicist and author of Soft Machines: Nanotechnology and Life, reviewed in Foresight Update Number 55 (2005) page 10. Basically Jones follows Eric Drexler’s lead in Engines of Creation in arguing that the molecular machinery found in nature provides an existence proof of an advanced nanotechnology of enormous capabilities. However, he cites the very different physics governing biomolecular machinery operating in an aqueous environment on the one hand, and macroscopic machine tools of steel and other hard metals, on the other hand. He then argues that rigid diamondoid structures doing atomically precise mechanochemistry, as later presented by Drexler in Nanosystems, although at least theoretically feasible, do not form a practical path to advanced nanotechnology. This stance occasioned several very useful and informative debates on the relative strengths and weaknesses of different approaches to advanced nanotechnology, both on his Soft Machines blog and here on Nanodot (for example “Debate with ‘Soft Machines’ continues“, “Which way(s) to advanced nanotechnology?“, “Recent commentary“). An illuminating interview of Richard Jones over at h+ Magazine not only presents Jones’s current views, but spotlights the lack of substantial effort since 2008 in trying to resolve these issues “Going Soft on Nanotech“:
… RJ: I’m both a fan of Eric Drexler and a critic — though perhaps it would be most correct to say I’m a critic of many of his fans. Like many people, I was inspired by the vision of Engines of Creation, in outlining what would be possible if we could make functional machines and devices at the nanoscale. If Engines set out the vision in general terms, Nanosystems was a very thorough attempt to lay out one possible concrete realisation of that vision. Looking back at it twenty years on, two things strike me about it. Read the rest of this entry »
Posted by Jim Lewis on August 24th, 2014
Schematic illustration for single-molecule motion capturing and manipulation of 1-nm sized synthetic molecular machine by optical microscopy using a bead probe. A large bead attached to the rotor part of the synthetic molecular bearing (double decker porphyrin) traces its motion. credit Tomohiro Ikeda
Molecular machines are a central component of efforts to develop atomically precise manufacturing. Optical microscopy and optical trap manipulation of single molecules, made possible by attachment of micrometer-scale beads, have facilitated greater understanding of the workings of biomolecular machines. For example, a 2008 paper published in Cell (“Intramolecular Strain Coordinates Kinesin Stepping Behavior along Microtubules“) revealed how the kinesin molecular motor molecule coordinates its two motor domains to achieve one-way stepping along microtubule proteins. When additional peptides were inserted into the mechanical “neck linker” elements that span the two motor domains, tension was reduced, and as a result, the motor’s velocity was reduced. Motor velocity returned to near normal when external tension was applied via an optical trap operating on a 920 nm diameter bead attached via an antibody to the molecular motor. Nanotechnologists can use similar techniques to study a wide variety of biomolecular machines, including naturally occurring molecular motors with typical length scales of 10 nm. Until now, however, it has not been possible to use similar approaches to study smaller synthetic molecular machines, with typical length scales on the order of one nm. A hat tip to Asian Scientist for reprinting this press release from the University of Tokyo “Seeing and touching a single 1-nm-sized synthetic molecular machine“:
Single-molecule imaging and manipulation with optical microscopy using a bead probe as a marker (single–molecule “motion capturing”) unveils fundamental properties of biomolecular machines such as direction of motion, step size and force the molecule exerts, which cannot be resolved by whole-molecule measurements. As a result, it has become an essential method for research of biomolecular machines. In addition, single-molecule motion capturing could also become a powerful tool to develop “synthetic” molecular machines. However, it is difficult to apply the conventional method to individual molecules because the size of a typical synthetic molecular machine is only 1 nm, about one-tenth the size of a biomolecular machine. This miniaturization of the target molecule causes significant problems such as low efficiency of the bead probe immobilization reaction and undesired interaction between the surfaces of the bead and substrate.
Read the rest of this entry »
Posted by Stephanie C on August 22nd, 2014
From MegaOm.com: "An origami robot transforming from flat to 3D. Photo courtesy of Seth Kroll, Wyss Institute."
Nanotech promises more commonplace access to advanced technology as material and fabrication costs fall and traditional barriers to innovation are removed. Examples are already being seen globally: more access to laptops and cell phones in developing countries, desktop 3D printers, a surge in establishment of shared-use research facilities, etc.
A couple recent cases getting attention on GigaOm.com include the latest release of RISC-based open source chip from UC Berkeley, and self-folding ‘origami’ robots developed at the Wyss Institute and published in Science.
About the chips:
Fed up with the limitations of current computer chips and their related intellectual property, a team of researchers at the University of California, Berkeley, is pushing an open source alternative. The RISC-V instruction set architecture was originally developed at the university to help teach computer architecture to students, but now its creators want to push it into the mainstream to help propel emerging markets such as cloud computing and the internet of things.
Read the rest of this entry »
Posted by Stephanie C on August 21st, 2014
Looks can be deceiving -- these gamers may be engaged in highly cooperative, albeit remote, team objectives. Credit: Reuters
Speaking of big computation, cyberspace isn’t yet as potent as Neal Stephenson portrayed in Snow Crash and subsequent books, but it’s getting there. A new article in the Wall Street Journal online titled Can World of Warcraft Game Skills Help Land a Job? states that some job seekers are adding gaming skills to their resumes to indicate their ability to work productively in large, remote teams:
Gamers’ ability to accomplish complex tasks across virtual teams could be seen as a plus for some companies.
“This capability to engage in strategy-building, team-building, knowledge-sharing and problem-solving remotely is really important,” said, Ms. LeGoues, currently vice president of transformation at the YAI Network of nonprofits.
The topic was also featured on the Harvard Business Review blog, and was picked up at Yahoo Finance (video and article here), noting that skill-based hobbies such as chess and even golf have been touted in LinkedIn profiles for some time:
…Still, excluding people who work at video game companies, less than 2,000 have mentioned World of Warcraft on their resumes on LinkedIn. More than 250,000 people list chess on their LinkedIn profile, mostly in the fields of IT, computer software and finance. That beats the 116,000 who list golfing skills, mainly in the fields of finance, real estate and marketing and advertising. Poker is less common, listed on only 43,000 profiles, and about half are people who work in the gaming industry. The rest, about 22,000, are concentrated in IT, advertising, and marketing and finance.
MIT researcher Michael Schrage says a whole bunch of modern, digital pursuits such as fantasy baseball and Minecraft should eventually become appealing to hiring companies, since they signify modern skills.
Feeling skeptical? How about flight simulators, which have been used for decades
to help train pilots but have only recently achieved high enough levels of computational sophistication to effectively prepare pilots for dangerous flight conditions that were previously relegated to ‘on the job training’.
Read the rest of this entry »
Posted by Stephanie C on August 14th, 2014
Hyve3D credit: University of Montreal
What 3D printers are doing to facilitate fabrication, 3D drawing programs are surpassing to facilitate design. As described at ScienceDaily.com, two systems referred to as “powerful” and “spectacular” are being highlighted at the SIGGRAPH 2014 conference in Vancouver this week:
True2Form (out of University of British Columbia) brings 2D sketches into 3D (excerpt from SD reprint):
…”In line-drawings, designers and artists use descriptive curves and informative viewpoints to convey the full shape of an object,” says Alla Sheffer, a professor in UBC’s Dept. of Computer Science. “Our system mimics the results of human three-dimensional shape inference to lift a sketch curve network into 3-D, while preserving fidelity to the original sketch.”
True2Form uses powerful mathematics to interpret artists’ strokes automatically lifting drawings off of the page. It produces convincing, complex 3-D shapes computed from individual sketches, automatically corrected to account for inherent drawing inaccuracy…
Hyve3D (out of University of Montreal) delivers collaborative, real-time 3D sketching (excerpt from SD reprint):
…For example, as the designers are immersed in their work, this could mean designing the outside of a car, and then actually getting into it to work on the interior detailing. Hyve-3D stands for “Hybrid Virtual Environment 3D.” Univalor, the university’s technology commercialization unit, is supporting the market launch of the system.
The 3D images are the result of an optical illusion created by a widescreen high-resolution projector, a specially designed 5m-diameter spherically concave fabric screen and a 16-inch dome mirror projecting the image onto the screen…
While industrial/commercial/military applications are pretty obvious, the potential for classrooms (remember trying to visualize molecular stereochemistry by pointing your fingers in unnatural directions?!), for emerging technologies, and for individual innovators (as these types of systems arrive in collaborative facilities or as costs/size come down to allow desktop versions) makes the imagination soar.
-Posted by Stephanie C
Posted by Stephanie C on August 13th, 2014
credit: Venkataraman et al., University of Massachusetts Amherst
Photovoltaics are an interesting case where atomic precision is not necessary to achieve potentially dramatic global impacts. Even an “ok efficiency” device that is easy to manufacture with reduced environmental hazard could have significant beneficial effects on energy resources and on device fabrication processes (which could, in turn, contribute to developments toward APM).
The struggle to balance ease of manufacture and device efficiency is a major driver behind current research efforts. Two recent publications out of Massachusetts alone make the point: Research from University of Massachusetts Amherst describes the fabrication of (very low efficiency) photovoltaic devices via tunable self-assembly of aqueous nanoparticle dispersions (organic nanospheres). The work is published in NanoLetters and the press release is reprinted at Phys.org here (excerpt below), and research from MIT utilizes quantum dots to reach a notable 9% efficiency (high for QD-based devices). This work is published in ACSNano and the press release also reprinted at Phys.org here.
A team of materials chemists, polymer scientists, device physicists and others at the University of Massachusetts Amherst today report a breakthrough technique for controlling molecular assembly of nanoparticles over multiple length scales that should allow faster, cheaper, more ecologically friendly manufacture of organic photovoltaics and other electronic devices. Details are in the current issue of Nano Letters.
Lead investigator, chemist Dhandapani Venkataraman, points out that the new techniques successfully address two major goals for device manufacture: controlling molecular assembly and avoiding toxic solvents like chlorobenzene. “Now we have a rational way of controlling this assembly in a water-based system,” he says. “It’s a completely new way to look at problems. With this technique we can force it into the exact structure that you want.”
-Posted by Stephanie C
Posted by Jim Lewis on August 10th, 2014
This scanning electron microscope image and schematic show the design and composition of new RRAM memory devices based on porous silicon oxide that were created at Rice University. Credit: Tour Group/Rice University
Investment in the ultimate promise of advanced or molecular nanotechnology, that is, molecular manufacturing or atomically precise manufacturing, may well rest upon the success of current nanoscale science and incremental nanotechnology. Computation represents a major area of investment for current nanotechnology. One researcher who has contributed greatly to both atomically precise devices leading toward molecular manufacturing, on the one hand, and current commercializable nanotechnology, on the other hand, is James Tour of Rice University, winner of the 2008 Foresight Institute Feynman Prize in the Experimental category. A hat tip to KurzweilAI for reprinting this Rice University news release “Rice’s silicon oxide memories catch manufacturers’ eye“:
Rice University’s breakthrough silicon oxide technology for high-density, next-generation computer memory is one step closer to mass production, thanks to a refinement that will allow manufacturers to fabricate devices at room temperature with conventional production methods.
First discovered five years ago, Rice’s silicon oxide memories are a type of two-terminal, “resistive random-access memory” (RRAM) technology. In a new paper available online in the American Chemical Society journal Nano Letters [abstract], a Rice team led by chemist James Tour compared its RRAM technology to more than a dozen competing versions.
“This memory is superior to all other two-terminal unipolar resistive memories by almost every metric,” Tour said. “And because our devices use silicon oxide — the most studied material on Earth — the underlying physics are both well-understood and easy to implement in existing fabrication facilities.” Tour is Rice’s T.T. and W.F. Chao Chair in Chemistry and professor of computer science and of materials science and nanoengineering.
Read the rest of this entry »
Posted by Jim Lewis on August 8th, 2014
(credit: Elicia Maine et al./Nature Nanotechnology)
We’ve suggested that biotechnology could serve as an enabling technology for the development of atomically precise manufacturing (through an opensource biological parts depository for building molecular machines and through a ground-breaking innovation to have robots do biotech experiments “in the cloud”). Whether or not the confluence of biotechnology and nanotech advances the development of atomically precise manufacturing, this confluence has already opened a path to new products and new markets. An article over at KurzweilAI reports two studies on opportunities in the emerging nanobiotechnology industry “Innovation management and the emergence of the nanobiotechnology industry“:
The confluence of nanotechnology and biotechnology is creating opportunities and an emerging industry, nanobiotechnology, with tremendous potential for economic and social value creation, according to an international research team at MIT, Simon Fraser University, and the University of New South Wales
The medical applications of nanobiotechnology are promising, including effectively targeted drug delivery — imagine highly efficacious cancer treatment with few side effects — and real time, minimally invasive diagnostics. But there is little known about the emergence of this industry or of ways to reap the possible benefits. …
Read the rest of this entry »
Posted by Jim Lewis on August 5th, 2014
credit The Emerald Cloud Laboratory
Recently we cited an alliance between Foresight and parts of the Bay Area biotech community to build an opensource biological parts repository, and we expressed the hope that spreading the meme that biological machines are indeed machines that can be engineered might seed efforts toward the open source development of molecular manufacturing. We thank Desiree D. Dudley of the Synthetic Neurobiology Group, MIT for letting us know of another Bay Area biotech initiative that might also speed development of molecular manufacturing (also known as atomically precise manufacturing). Emerald Therapeutics, whose co-founder DJ Kleinbaum spoke on “Democratizing Biotechnology” at the 2014 Foresight Technical Conference, has just announced The Emerald Cloud Laboratory, “a web-based life sciences lab, developed by scientists for scientists.” From Ashlee Vance at Bloomberg Businessweek “Emerald Therapeutics: Biotech Lab for Hire“:
There’s a basic formula these days for anyone looking to develop a cure for a disease. Along with a good idea, you need $20 million, a team of about 30 scientists, and a year to set up the lab equipment to start testing your theory. From there, the grunt work begins, as your team of well-paid researchers squirts fluid into test tubes, feeds chemicals into machines, and analyzes the results from thousands of experiments. If you luck out and discover something useful, then it’s time to pray that the desired result can be replicated.
Read the rest of this entry »
Posted by Stephanie C on July 29th, 2014
Nicholas Negroponte, founder of the MIT media lab and the One Laptop Per Child program, gave a TED talk in March 2014 titled A 30-Year History of the Future. Click to access the talk or the TEDBlog article discussing the talk.
Negroponte highlights some cutting-edge technological developments of the past that had been openly scorned by nay-sayers, including early touch screens and the prediction that books and newspapers would be widely accessed via the internet.
Negroponte also describes some unexpected and inspiring results of giving tablets to children, with no training or instructions provided.
Of course hindsight is always 20/20, but some of the nay-sayers Negroponte encountered may have been viewing computation as competitive with the human experience, while in fact history is showing that, in many cases, computation is supporting and enhancing the human experience.
Posted by Jim Lewis on July 24th, 2014
A popular added event at the February 2014 Foresight Conference was the B.R.AI.N.S Immortalist Audit focusing on what self-described “Life-Extensionists” are doing to cure disease and extend healthy human life, and how attendees could help. Photos from the Conference present a who’s who of principal players in biotechnology-, and life extension-related startups and research organizations. An April 16 B.R.AI.N.S salon on Human Biology and Freedom capped a successful Crowdtilt community fundraising campaign to build a strategic alliance between B.R.AI.N.S., Berkeley BioLabs and Foresight Institute to build an opensource biological parts repository and design and distribute a line of “How-to Build Biological Machines” educational kits.
Read the rest of this entry »
Posted by Jim Lewis on July 11th, 2014
Aubrey de Grey, Co-Founder and Chief Science Officer, SENS Research Foundation
Rejuvenation Biotechnology Conference
August 21-23, 2014 · Santa Clara, California
Conference brochure (pdf)
We are in the midst of a transformation in the way we search for cures to the diseases of aging. The prevalence of age-related diseases is spiraling and the socioeconomic impacts are a constant source of debate. Subsequently, interest in preventing such diseases through novel approaches to drug development is at an all-time high.
The Rejuvenation Biotechnology Conference is the latest SENS Research Foundation Conference and will be held on August 21-23 at the Hyatt Regency in Santa Clara, California. Join the growing rejuvenation biotechnology industry and hear the latest scientific and policy developments from leading experts in research, industry, policy, finance and regulatory fields.
25% discount for the longevity research conference from SENS Foundation this Aug. 21-23 in Santa Clara, CA. Early rate Extended Until July 14th.
To Foresight members and friends,
Ever since the longevity research conference series called SENS — Strategies for Engineering Negligible Senescence, chaired by Aubrey de Grey — began in 2003, I’ve longed to attend, but never could, because it’s held at Cambridge University in the UK, putting the cost out of reach.
Now, finally, SENS Foundation has started a conference in the U.S., with the first one this August 21-23 here in Silicon Valley!
To get your costs down further, do two things:
- Register by July 14 to get the early rate.
- Use the discount code FORESIGHT25 to get an additional 25% off.
This is a ground-breaking meeting featuring true “rock stars” of longevity research, including George Church, Judith Campisi, Michael West, and 37 others.
To round out the event, there’s a keynote by Ajay Royan of Mithril Capital Management, and even appearances by leaders from the entertainment world: comedian Hal Sparks, actor Edward James Olmos, and Cecilia Noel, the “Latin Tina Turner.”
This promises to be the most informative and engaging longevity research event ever held. I wouldn’t miss it, so please join Foresight president Paul Melnyk, Gayle Pergamit, Tanya Jones, myself, and other friends this August in Santa Clara.
Hope to see you there!
Co-Founder, Foresight Institute
Posted by Stephanie C on July 11th, 2014
Credit: NNI at nano.gov
Just when it seemed like debate over the National Nanotechnology Initiative was a thing of the past (see Foresight’s disappointment in 2008 here), disagreements regarding re-authorization and budget cuts are prompting politicians and researchers to take a detailed look at what the program supports and what it is achieving.
Witnesses to the House Research Subcommittee hearing, held this past May, included Timothy Persons of US GAO, who spoke at Foresight’s 2014 Integration Conference (and whose work indicating shortfalls in US manufacturing and policy is highlighted in a recent Nanodot post here), and Lloyd Whitman of CNST who emphasized the great strides made in building collaborative facilities that support decentralization of technological advancement, also a key area of discussion at the Integration Conference.
Some highlights from the hearing appear in the American Institute of Physics online bulletin:
The Research Subcommittee of the House Science, Space and Technology Committee held a hearing on May 20 during which Members examined nanotechnology research and development and discussed the National Nanotechnology Initiative (NNI). Both parties noted that the House of Representatives had previously passed a reauthorization of this Initiative but that the Senate did not. There was bi-partisan interest from Members of the subcommittee to again attempt to reauthorize NNI.
Subcommittee Chairman Larry Bucshon (R-IN) opened the hearing by describing the development of nanomaterials and listing many products developed due to nanotechnology. “In 2013, the National Science Foundation (NSF) nanotechnology investment supported 5,000 active projects, over 30 research centers and several infrastructure networks for device development, computation, and education,” noted Bucshon as he highlighted the 150 small businesses that were funded through the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR) Programs. Bucshon was displeased at the President’s budget request for NSF directorates that support nanotechnology research, noting the $1.5 million decrease in the FY 2015 budget for those directorates.
Read the rest of this entry »