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Micrometer-scale structures built from DNA bricks

A general framework is presented for using 32-nucleotide DNA bricks to build large two-dimensional crystals up to 80 nm thick and incorporating sophisticated three-dimensional features.

Arbitrarily complex 3D DNA nanostructures built from DNA bricks

A set of 32-nucleotide single strand DNA bricks was designed so that each can interact independently with four other DNA bricks so that sets of hundreds of bricks can self-assemble into arbitrarily complex 25-nm 3D shapes, each comprising 1000 8-base pair volume elements.

Macroscopic DNA crystals from molecular tensegrity triangles

Structural DNA nanotechnology: progress toward a precise self-assembling three dimensional scaffold by building macroscopic crystals from nanoscale structures.

Tightly-fitted DNA parts form dynamic nanomachine

A rotor with DNA origami parts held together by an engineered tight fit instead of by covalent bonds can revolve freely, driven by Brownian motion and dwelling at engineered docking sites.

DNA nanotechnology guides assembling cells into ‘Organoids’

DNA strands decorating cell membranes like ‘Velcro’ program the adhesion of cells to other cells or to extracellular matrices to build tiny tissue models.

Automated design of polyhedral meshes for DNA origami

An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.

Arranging molecular chromophores on DNA brick nanobreadboards

Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.

Bigger, stiffer, roomier molecular cages from structural DNA nanotechnology

Using struts made of DNA to stiffen polyhedral corners, scientists have build rigid DNA cages an order of magnitude larger than previous DNA nanostructures, and only one order of magnitude smaller than bacterial cells.

Mass production of higher quality oligonucleotides to spur DNA nanotechnology

Biotechnology-based isolation and amplification of sequence-verified clones of DNA oligonucleotides will provide longer and less expensive materials for building complex DNA nanostructures and nanomachinery.

Testing and improving scaffolded DNA origami for molecular nanotechnology

In two different sets of experiments a German research group has shown that scaffolded DNA origami can be used to assemble complex structures with precise sub-nanometer positional control, and that constant temperature reaction can greatly increase yields and decrease production times.

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