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RNA nanotechnology - fewer structures in living cells than in test tubes

Tuesday, January 14th, 2014

A study of RNA structures actually present in cells reveals that cells spend energy restricting thermodynamically driven RNA folding so that fewer RNA structures are found in cells than in test tubes.

New online game to design RNA molecules: advancing nanotechnology?

Monday, July 16th, 2012

A new online game allows players to design RNA molecules. The most promising designs are synthesized, and the players given real-world feedback on how well their designs worked.

Novel RNA structural motifs expand tool kit for RNA nanotechnology

Sunday, February 26th, 2012

New computational methods to explore the rapidly expanding collection of high resolution three-dimensional RNA structures reveal new RNA structural motifs, identifying additional building blocks for complex RNA nanostructures.

RNA CAD tool for synthetic biology may facilitate RNA nanotechnology

Tuesday, December 27th, 2011

RNA CAD tools developed for RNA-regulated control of gene expression in synthetic biology successfully engineered metabolic pathways in bacteria. Will engineering RNA-based genetic control systems lead to design tools for other RNA-based molecular machine systems?

New electron diffraction method for nanotechnology determines nanostrucutres in days instead of years

Friday, September 23rd, 2011

Automated diffraction tomography provides rapid determination of structure of zeolite to atomic precision.

Handling flexible parts in RNA nanotechnology

Thursday, June 30th, 2011

New computational method screens for small molecules that bind to RNA molecules that move through a variety of conformations.

Protein, RNA, DNA: Nanotechnology finds a multitude of paths to attack cancer cells

Monday, May 2nd, 2011

Protein, RNA, DNA provide very different molecular architectures for nanotechnology to adopt to deliver drugs to cancer cells while sparing healthy cells.

High-resolution structure reveals versatility of RNA nanotechnology

Sunday, April 17th, 2011

A high-resolution crystal structure of a small square made by self-assembly of RNA molecules reveals each corner of the square to have a unique structure.

Advance could speed RNA nanotechnology

Thursday, January 20th, 2011

RNA nanostructures chemically modified to be resistant to degradation retain 3D structure and biological activity.

Programming cell behavior with RNA nanotechnology

Thursday, October 23rd, 2008

Nanotech applications based upon modules of RNA that bind small molecules to control the catalytic activity of other RNA modules may form the basis for a wide variety of synthetic molecular machines.

Structural alphabet of RNA may advance RNA nanotechnology

Wednesday, March 12th, 2008

A developing understanding of non-Watson-Crick interactions places RNA nanotech on a firmer foundation.