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Bigger, stiffer, roomier molecular cages from structural DNA nanotechnology

Saturday, March 29th, 2014

Using struts made of DNA to stiffen polyhedral corners, scientists have build rigid DNA cages an order of magnitude larger than previous DNA nanostructures, and only one order of magnitude smaller than bacterial cells.

Will crowdsourced RNA designs advance nanotechnology?

Thursday, March 6th, 2014

A very large community of online gamers has consistently produced RNA designs that outperform the best design algorithms by a large margin. Can online gamers designing RNA, protein, and other molecules contribute to the development of atomically precise manufacturing?

DNA nanotechnology positions components to optimize single-molecule fluorescence

Friday, July 19th, 2013

A pillar constructed and positioned using DNA nanotechnology holds two gold nanoparticles and a dye molecule to enhance fluorescence over a hundred fold.

Reviews of DNA nanotechnology-atomically precise microscale objects

Tuesday, July 9th, 2013

Two open access reviews portray the widening approach of DNA nanotechnology toward more complex atomically precise systems.

Mass production of higher quality oligonucleotides to spur DNA nanotechnology

Thursday, June 6th, 2013

Biotechnology-based isolation and amplification of sequence-verified clones of DNA oligonucleotides will provide longer and less expensive materials for building complex DNA nanostructures and nanomachinery.

Re-engineering a junction to give a new twist to DNA nanotechnology

Friday, March 29th, 2013

By forcing the geometry of the junctions upon which DNA nanotechnology depends, researchers have increased the collection of 2D and 3D structures that they can build to include wire frames and mesh structures.

Testing and improving scaffolded DNA origami for molecular nanotechnology

Wednesday, December 19th, 2012

In two different sets of experiments a German research group has shown that scaffolded DNA origami can be used to assemble complex structures with precise sub-nanometer positional control, and that constant temperature reaction can greatly increase yields and decrease production times.

Arbitrarily complex 3D DNA nanostructures built from DNA bricks

Thursday, December 6th, 2012

A set of 32-nucleotide single strand DNA bricks was designed so that each can interact independently with four other DNA bricks so that sets of hundreds of bricks can self-assemble into arbitrarily complex 25-nm 3D shapes, each comprising 1000 8-base pair volume elements.

Biological molecular motors programmed to run DNA chasis

Wednesday, October 17th, 2012

Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.

Assembling biomolecular nanomachines: a path to a nanofactory?

Thursday, October 4th, 2012

A “cut and paste” method uses an atomic force microscope to assemble protein and DNA molecules to form arbitrarily complex patterns on a surface. Developing this approach to form enzymatic assembly lines could be a path toward a general purpose nanofactory.

Toward a method to design any needed catalyst?

Monday, August 6th, 2012

Computational insights into a fundamental organic synthesis reaction may lead to the ability to design a catalyst for any desired reaction.

Atomically precise nanoparticle provides better drug delivery

Tuesday, July 10th, 2012

Nanoparticles made from specific DNA and RNA strands, homogeneous in size, composition, and surface chemistry, proved superior to other nanoparticles in silencing gene expression in tumors in mouse experiments.

DNA tiles provide faster, less expensive way to fabricate complex DNA objects

Thursday, May 31st, 2012

A set of 310 short single-stranded DNA tiles, plus a few additional short sequences for the edges, has been used to form more than a hundred large, complex DNA objects.

Will piezoelectric graphene provide options for nanoscale manipulation?

Wednesday, April 25th, 2012

Calculations using density functional theory have demonstrated that graphene can be made piezoelectric by adsorbing atoms or molecules on one surface, or by adsorbing different atoms or molecules on each surface.

DNA nanotechnology-based nanorobot delivers cell suicide message to cancer cells

Thursday, March 8th, 2012

Functioning DNA nanorobots to deliver specific molecular signals to cells were designed by combining DNA origami, DNA aptamers, and DNA logic gates.

DNA motor navigates network of DNA tracks

Tuesday, January 31st, 2012

Scientists at Kyoto University and the University of Oxford have combined DNA origami and DNA motors to take another step toward programmed artificial molecular assembly lines.

Arrays of artificial molecular machines could lead to atomically precise nanotechnology

Thursday, December 29th, 2011

A tutorial review available after free registration presents a theory-based exploration of the difficulty in moving from simple molecular switches to arrays of artificial molecular machines capable to doing substantial, useful external work.

Mechanical pressure produces atomically-precise, multifunctional 2D sheets

Monday, December 26th, 2011

Protein-like structures called peptoids can be formed into stable, free-floating nanosheets.

Geometry of DNA nanostructures used to program molecular recognition

Friday, November 25th, 2011

Adding a new molecular recognition code to structural DNA nanotechnology—a pattern of projecting and recessed blunt-end DNA helices can be used to code the assembly of DNA origami tiles into larger DNA nanostructures.

A modular molecular composite nanosystem for solar power

Tuesday, May 17th, 2011

A bacterial virus called M13 was genetically engineered to control the arrangement of carbon nanotubes, improving solar-cell efficiency by nearly one-third.