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Novel wireframe nanostructures from new DNA origami design process

Tuesday, August 18th, 2015

A new set of design rules enables constructing any wireframe nanostructure, which may lead to new medical applications and new nanomachines.

Automated design of polyhedral meshes for DNA origami

Friday, August 7th, 2015

An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.

Arranging molecular chromophores on DNA brick nanobreadboards

Thursday, August 6th, 2015

Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.

Facilitating structural DNA nanotechnology with non-aqueous solvents

Sunday, August 2nd, 2015

Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.

Foresight co-sponsors Berkeley Bench to Market event

Thursday, July 30th, 2015

To educate potential entrepreneurs on strategies for moving discoveries from the benchtop to successful commercialization, Foresight co-sponsored an event in the “Ph.D. to Startup” Workshop Series of the Berkeley Postdoc Entrepreneur Program.

Linking together small DNAs to build more diverse DNA nanostructures

Thursday, July 2nd, 2015

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

Conference video: Regenesis: Bionano

Tuesday, June 9th, 2015

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Dynamic nanomachines for DNA nanotechnology inspired by proteins

Thursday, June 4th, 2015

Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.

Preserving protein function in DNA-protein nanostructures

Monday, June 1st, 2015

Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.

Solid-phase synthesis of custom-made DNA nanotubes

Thursday, April 9th, 2015

Single-molecule spectroscopy makes possible adding one rung at a time to a foundational rung grafted to a surface to make a long nanotube scaffold of predetermined sequence.

DNA nanoswitches open window on molecular interactions

Sunday, April 5th, 2015

Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.

Cotranscriptional folding of single RNA strand added to nanotechnology toolkit

Tuesday, March 31st, 2015

RNA origami brings new dimensions to nucleic acid nanotechnology by exploiting the much greater variety of RNA structural motifs (compared to DNA) to do what cannot easily be done with DNA origami, like fold into predetermined nanostructures rapidly while being transcribed.

Designing mechanical functions into DNA nanotechnology

Tuesday, March 3rd, 2015

An overview of three decades of progress in DNA nanotechnology emphasizes bringing programmed motion to DNA nanostructures, including efforts to incorporate design principles from macroscopic mechanical engineering.

A tunable hinge joint for DNA nanotechnology

Saturday, January 31st, 2015

Variable length single-stranded DNA springs determine how far a hinge of double-stranded DNA joining two stiff sections of DNA origami can bend.

Structural DNA nanotechnology with programmed motions

Wednesday, January 28th, 2015

Scaffolded DNA origami is combined with hinges of single- or double-stranded DNA to built simple machines parts that have been combined to program simple to complex motions.

Swarms of DNA nanorobots execute complex tasks in living animal

Tuesday, January 6th, 2015

Combinations of different types of DNA nanorobots, implementing different logic gates, work together to tag a specific type of cell in a living cockroach depending on the presence or absence of two protein signals.

Computational framework for structural DNA nanotechnology

Saturday, December 27th, 2014

A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?

Large, open protein cages designed and built

Sunday, December 7th, 2014

Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.

Using DNA nanotechnology to cast arbitrarily shaped nanoparticles

Tuesday, November 11th, 2014

Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.

DNA nanotechnology and the atoms to micrometer nanofabrication gap

Friday, September 26th, 2014

A new DARPA program seeks to bridge the gap from atoms to macroscale product manufacture in two steps, the first of which is from atoms to micrometer-scale feedstocks. DNA origami may be part of the solution.