Enveloped DNA nanostructures were developed to escape attacks from nucleases and the immune system, opening a path to ever more sophisticated DNA nanomedical devices.
The complex molecular recognition code of RNA offers RNA nanotechnology a greater variety of 3D structures and functions than are present in DNA nanotechnology, but the RNA structures can be fragile. New RNA triangles that resist boiling solve this problem.
Using struts made of DNA to stiffen polyhedral corners, scientists have build rigid DNA cages an order of magnitude larger than previous DNA nanostructures, and only one order of magnitude smaller than bacterial cells.
A very large community of online gamers has consistently produced RNA designs that outperform the best design algorithms by a large margin. Can online gamers designing RNA, protein, and other molecules contribute to the development of atomically precise manufacturing?
A pillar constructed and positioned using DNA nanotechnology holds two gold nanoparticles and a dye molecule to enhance fluorescence over a hundred fold.
Two open access reviews portray the widening approach of DNA nanotechnology toward more complex atomically precise systems.
Biotechnology-based isolation and amplification of sequence-verified clones of DNA oligonucleotides will provide longer and less expensive materials for building complex DNA nanostructures and nanomachinery.
By forcing the geometry of the junctions upon which DNA nanotechnology depends, researchers have increased the collection of 2D and 3D structures that they can build to include wire frames and mesh structures.
In two different sets of experiments a German research group has shown that scaffolded DNA origami can be used to assemble complex structures with precise sub-nanometer positional control, and that constant temperature reaction can greatly increase yields and decrease production times.
A set of 32-nucleotide single strand DNA bricks was designed so that each can interact independently with four other DNA bricks so that sets of hundreds of bricks can self-assemble into arbitrarily complex 25-nm 3D shapes, each comprising 1000 8-base pair volume elements.
Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.
A “cut and paste” method uses an atomic force microscope to assemble protein and DNA molecules to form arbitrarily complex patterns on a surface. Developing this approach to form enzymatic assembly lines could be a path toward a general purpose nanofactory.
Computational insights into a fundamental organic synthesis reaction may lead to the ability to design a catalyst for any desired reaction.
Nanoparticles made from specific DNA and RNA strands, homogeneous in size, composition, and surface chemistry, proved superior to other nanoparticles in silencing gene expression in tumors in mouse experiments.
A set of 310 short single-stranded DNA tiles, plus a few additional short sequences for the edges, has been used to form more than a hundred large, complex DNA objects.
Calculations using density functional theory have demonstrated that graphene can be made piezoelectric by adsorbing atoms or molecules on one surface, or by adsorbing different atoms or molecules on each surface.
Functioning DNA nanorobots to deliver specific molecular signals to cells were designed by combining DNA origami, DNA aptamers, and DNA logic gates.
Scientists at Kyoto University and the University of Oxford have combined DNA origami and DNA motors to take another step toward programmed artificial molecular assembly lines.
A tutorial review available after free registration presents a theory-based exploration of the difficulty in moving from simple molecular switches to arrays of artificial molecular machines capable to doing substantial, useful external work.
Protein-like structures called peptoids can be formed into stable, free-floating nanosheets.