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Macroscopic DNA crystals from molecular tensegrity triangles

Monday, May 2nd, 2016

Structural DNA nanotechnology: progress toward a precise self-assembling three dimensional scaffold by building macroscopic crystals from nanoscale structures.

DNA nanotechnology defeats drug resistance in cancer cells

Saturday, April 2nd, 2016

Small, stiff, rectangular rods made using scaffolded DNA origami bypass drug resistance mechanisms in the membranes of a cultured leukemia cell line and release enough therapeutic drug to kill the cancer cell.

Caltech celebrates ten years of Scaffolded DNA Origami

Monday, March 14th, 2016

California Institute of Technology is holding a symposium to honor Paul Rothemund’s seminal contribution to the field of DNA nanotechnology: the research paths opened by the technology, and where they might lead.

Tightly-fitted DNA parts form dynamic nanomachine

Thursday, March 10th, 2016

A rotor with DNA origami parts held together by an engineered tight fit instead of by covalent bonds can revolve freely, driven by Brownian motion and dwelling at engineered docking sites.

DNA nanotechnology provides new ways to arrange nanoparticles into crystal lattices

Friday, February 19th, 2016

Two research teams present two different methods for using single strands of DNA to link various nanoparticles into complex 3D arrays: one using DNA hairpins for dynamic reconfiguration and the other using a DNA origami scaffold.

DNA nanotechnology cages localize and optimize enzymatic reactions

Tuesday, February 16th, 2016

Encapsulating enzymes in nanocages engineered using structural DNA nanotechnology increases enzymatic digestion and protects enzymes from degradation.

Conference video: Nanoscale Materials, Devices, and Processing Predicted from First Principles

Friday, January 15th, 2016

Prof. William Goddard presented four advances from his research group that enable going from first principles quantum mechanics calculations to realistic nanosystems of interest with millions or billions of atoms.

Ultrasensitive microRNA assay with nanosensor to detect cancer

Thursday, December 10th, 2015

A nanotechnology-based sensor provides fast, inexpensive, ultrasensitive assay of microRNA pattern to detect cancer using DNA immobilized on a synthetic gold nanoprism.

Using DNA nanotechnology to position molecules with atomic precision

Wednesday, December 9th, 2015

German researchers have used scaffolded DNA origami to adjust the angle of a DNA hinge joint by altering the length of special “adjuster helices”, causing molecules attached to the sides of the hinge to be displaced by as little as 0.04 nm.

Surface assisted self-assembly of DNA origami nanostructures

Monday, October 26th, 2015

A lipid bilayer supported by a mica surface assisted the mobile self-assembly of DNA nanostructures of various shapes into micrometer-scale 2D lattices.

Parallel to protein folding improves DNA origami process

Sunday, September 27th, 2015

Designing a small DNA origami that can fold in several almost equivalent ways demonstrates how understanding and guiding the folding pathway can improve the efficiency of the folding process, potentially leading in more complex situations to higher yields of the desired nanostructure and fewer misfolded structures.

Novel wireframe nanostructures from new DNA origami design process

Tuesday, August 18th, 2015

A new set of design rules enables constructing any wireframe nanostructure, which may lead to new medical applications and new nanomachines.

Automated design of polyhedral meshes for DNA origami

Friday, August 7th, 2015

An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.

Arranging molecular chromophores on DNA brick nanobreadboards

Thursday, August 6th, 2015

Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.

Facilitating structural DNA nanotechnology with non-aqueous solvents

Sunday, August 2nd, 2015

Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.

Foresight co-sponsors Berkeley Bench to Market event

Thursday, July 30th, 2015

To educate potential entrepreneurs on strategies for moving discoveries from the benchtop to successful commercialization, Foresight co-sponsored an event in the “Ph.D. to Startup” Workshop Series of the Berkeley Postdoc Entrepreneur Program.

Linking together small DNAs to build more diverse DNA nanostructures

Thursday, July 2nd, 2015

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

Conference video: Regenesis: Bionano

Tuesday, June 9th, 2015

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Dynamic nanomachines for DNA nanotechnology inspired by proteins

Thursday, June 4th, 2015

Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.

Preserving protein function in DNA-protein nanostructures

Monday, June 1st, 2015

Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.