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Linking together small DNAs to build more diverse DNA nanostructures

Thursday, July 2nd, 2015

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

Conference video: Regenesis: Bionano

Tuesday, June 9th, 2015

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Dynamic nanomachines for DNA nanotechnology inspired by proteins

Thursday, June 4th, 2015

Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.

Preserving protein function in DNA-protein nanostructures

Monday, June 1st, 2015

Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.

Solid-phase synthesis of custom-made DNA nanotubes

Thursday, April 9th, 2015

Single-molecule spectroscopy makes possible adding one rung at a time to a foundational rung grafted to a surface to make a long nanotube scaffold of predetermined sequence.

DNA nanoswitches open window on molecular interactions

Sunday, April 5th, 2015

Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.

Cotranscriptional folding of single RNA strand added to nanotechnology toolkit

Tuesday, March 31st, 2015

RNA origami brings new dimensions to nucleic acid nanotechnology by exploiting the much greater variety of RNA structural motifs (compared to DNA) to do what cannot easily be done with DNA origami, like fold into predetermined nanostructures rapidly while being transcribed.

Designing mechanical functions into DNA nanotechnology

Tuesday, March 3rd, 2015

An overview of three decades of progress in DNA nanotechnology emphasizes bringing programmed motion to DNA nanostructures, including efforts to incorporate design principles from macroscopic mechanical engineering.

A tunable hinge joint for DNA nanotechnology

Saturday, January 31st, 2015

Variable length single-stranded DNA springs determine how far a hinge of double-stranded DNA joining two stiff sections of DNA origami can bend.

Structural DNA nanotechnology with programmed motions

Wednesday, January 28th, 2015

Scaffolded DNA origami is combined with hinges of single- or double-stranded DNA to built simple machines parts that have been combined to program simple to complex motions.

Swarms of DNA nanorobots execute complex tasks in living animal

Tuesday, January 6th, 2015

Combinations of different types of DNA nanorobots, implementing different logic gates, work together to tag a specific type of cell in a living cockroach depending on the presence or absence of two protein signals.

Computational framework for structural DNA nanotechnology

Saturday, December 27th, 2014

A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?

Large, open protein cages designed and built

Sunday, December 7th, 2014

Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.

Using DNA nanotechnology to cast arbitrarily shaped nanoparticles

Tuesday, November 11th, 2014

Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.

DNA nanotechnology and the atoms to micrometer nanofabrication gap

Friday, September 26th, 2014

A new DARPA program seeks to bridge the gap from atoms to macroscale product manufacture in two steps, the first of which is from atoms to micrometer-scale feedstocks. DNA origami may be part of the solution.

Scaffolded DNA origami improvements advance DNA nanotechnology

Thursday, September 25th, 2014

A 10-fold larger breadboard and 350-fold lower DNA synthesis costs make DNA origami a more useful stepping-stone toward atomically precise manufacturing.

Proof of principle for nanoscale assembly line

Tuesday, September 2nd, 2014

Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.

Recent cases of 'accessible' high-tech: Open source chips & Origami robots

Friday, August 22nd, 2014

Nanotech promises more commonplace access to advanced technology as material and fabrication costs fall and traditional barriers to innovation are removed. Examples are already being seen globally: more access to laptops and cell phones in developing countries, desktop 3D printers, a surge in establishment of shared-use research facilities, etc. A couple recent cases getting attention [...]

Lipid coat protects DNA nanorobot from immune attack

Saturday, July 5th, 2014

Enveloped DNA nanostructures were developed to escape attacks from nucleases and the immune system, opening a path to ever more sophisticated DNA nanomedical devices.

Robust triangular RNA brick adds to RNA nanotechnology toolkit

Tuesday, June 24th, 2014

The complex molecular recognition code of RNA offers RNA nanotechnology a greater variety of 3D structures and functions than are present in DNA nanotechnology, but the RNA structures can be fragile. New RNA triangles that resist boiling solve this problem.